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Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Epilepsy and Their Interaction with Antiseizure Medications

Epilepsy is a life-threatening neurological disease that affects approximately 70 million people worldwide. Although the vast majority of patients may be successfully managed with currently used antiseizure medication (ASM), the search for alternative therapies is still necessary due to pharmacoresi...

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Autores principales: Tesiye, Maryam Rahimi, Gol, Mohammad, Fadardi, Mohammad Rajabi, Kani, Seyede Nasim Mousavi, Costa, Anna-Maria, Ghasemi-Kasman, Maryam, Biagini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777461/
https://www.ncbi.nlm.nih.gov/pubmed/36552892
http://dx.doi.org/10.3390/cells11244129
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author Tesiye, Maryam Rahimi
Gol, Mohammad
Fadardi, Mohammad Rajabi
Kani, Seyede Nasim Mousavi
Costa, Anna-Maria
Ghasemi-Kasman, Maryam
Biagini, Giuseppe
author_facet Tesiye, Maryam Rahimi
Gol, Mohammad
Fadardi, Mohammad Rajabi
Kani, Seyede Nasim Mousavi
Costa, Anna-Maria
Ghasemi-Kasman, Maryam
Biagini, Giuseppe
author_sort Tesiye, Maryam Rahimi
collection PubMed
description Epilepsy is a life-threatening neurological disease that affects approximately 70 million people worldwide. Although the vast majority of patients may be successfully managed with currently used antiseizure medication (ASM), the search for alternative therapies is still necessary due to pharmacoresistance in about 30% of patients with epilepsy. Here, we review the effects of ASMs on stem cell treatment when they could be, as expected, co-administered. Indeed, it has been reported that ASMs produce significant effects on the differentiation and determination of stem cell fate. In addition, we discuss more recent findings on mesenchymal stem cells (MSCs) in pre-clinical and clinical investigations. In this regard, their ability to differentiate into various cell types, reach damaged tissues and produce and release biologically active molecules with immunomodulatory/anti-inflammatory and regenerative properties make them a high-potential therapeutic tool to address neuroinflammation in different neurological disorders, including epilepsy. Overall, the characteristics of MSCs to be genetically engineered, in order to replace dysfunctional elements with the aim of restoring normal tissue functioning, suggested that these cells could be good candidates for the treatment of epilepsy refractory to ASMs. Further research is required to understand the potential of stem cell treatment in epileptic patients and its interaction with ASMs.
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spelling pubmed-97774612022-12-23 Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Epilepsy and Their Interaction with Antiseizure Medications Tesiye, Maryam Rahimi Gol, Mohammad Fadardi, Mohammad Rajabi Kani, Seyede Nasim Mousavi Costa, Anna-Maria Ghasemi-Kasman, Maryam Biagini, Giuseppe Cells Review Epilepsy is a life-threatening neurological disease that affects approximately 70 million people worldwide. Although the vast majority of patients may be successfully managed with currently used antiseizure medication (ASM), the search for alternative therapies is still necessary due to pharmacoresistance in about 30% of patients with epilepsy. Here, we review the effects of ASMs on stem cell treatment when they could be, as expected, co-administered. Indeed, it has been reported that ASMs produce significant effects on the differentiation and determination of stem cell fate. In addition, we discuss more recent findings on mesenchymal stem cells (MSCs) in pre-clinical and clinical investigations. In this regard, their ability to differentiate into various cell types, reach damaged tissues and produce and release biologically active molecules with immunomodulatory/anti-inflammatory and regenerative properties make them a high-potential therapeutic tool to address neuroinflammation in different neurological disorders, including epilepsy. Overall, the characteristics of MSCs to be genetically engineered, in order to replace dysfunctional elements with the aim of restoring normal tissue functioning, suggested that these cells could be good candidates for the treatment of epilepsy refractory to ASMs. Further research is required to understand the potential of stem cell treatment in epileptic patients and its interaction with ASMs. MDPI 2022-12-19 /pmc/articles/PMC9777461/ /pubmed/36552892 http://dx.doi.org/10.3390/cells11244129 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tesiye, Maryam Rahimi
Gol, Mohammad
Fadardi, Mohammad Rajabi
Kani, Seyede Nasim Mousavi
Costa, Anna-Maria
Ghasemi-Kasman, Maryam
Biagini, Giuseppe
Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Epilepsy and Their Interaction with Antiseizure Medications
title Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Epilepsy and Their Interaction with Antiseizure Medications
title_full Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Epilepsy and Their Interaction with Antiseizure Medications
title_fullStr Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Epilepsy and Their Interaction with Antiseizure Medications
title_full_unstemmed Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Epilepsy and Their Interaction with Antiseizure Medications
title_short Therapeutic Potential of Mesenchymal Stem Cells in the Treatment of Epilepsy and Their Interaction with Antiseizure Medications
title_sort therapeutic potential of mesenchymal stem cells in the treatment of epilepsy and their interaction with antiseizure medications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777461/
https://www.ncbi.nlm.nih.gov/pubmed/36552892
http://dx.doi.org/10.3390/cells11244129
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