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Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss?

The purpose of this article is to assess the present knowledge about chronic active (CA) T-cell mediated rejection (TCMR) of a kidney. In the research authors review current Banff diagnostic criteria used in kidney rejection, focus on their possible future evolution, and investigate the role of curr...

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Autores principales: Mizera, Jakub, Pilch, Justyna, Kamińska, Dorota, Krajewska, Magdalena, Donizy, Piotr, Banasik, Mirosław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777502/
https://www.ncbi.nlm.nih.gov/pubmed/36553226
http://dx.doi.org/10.3390/diagnostics12123220
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author Mizera, Jakub
Pilch, Justyna
Kamińska, Dorota
Krajewska, Magdalena
Donizy, Piotr
Banasik, Mirosław
author_facet Mizera, Jakub
Pilch, Justyna
Kamińska, Dorota
Krajewska, Magdalena
Donizy, Piotr
Banasik, Mirosław
author_sort Mizera, Jakub
collection PubMed
description The purpose of this article is to assess the present knowledge about chronic active (CA) T-cell mediated rejection (TCMR) of a kidney. In the research authors review current Banff diagnostic criteria used in kidney rejection, focus on their possible future evolution, and investigate the role of currently available molecular methods that could be implemented into the diagnostic scheme. Research also points out previously and currently available treatment methods applied to CA TCMR and takes into account possible side effects consequent upon the therapy. Moreover, attention is being paid to the CA TCMR coincidence with other kidney rejection types such as antibody-mediated rejection (ABMR) and its influence on the treatment approach. Authors also mark the possibility of non-HLA antibodies coexistence in patients with CA TCMR and describe its possible resonance on kidney allograft function. Nonetheless, it seems that current knowledge about CA TCMR is not sufficient and requires further investigation.
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spelling pubmed-97775022022-12-23 Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss? Mizera, Jakub Pilch, Justyna Kamińska, Dorota Krajewska, Magdalena Donizy, Piotr Banasik, Mirosław Diagnostics (Basel) Review The purpose of this article is to assess the present knowledge about chronic active (CA) T-cell mediated rejection (TCMR) of a kidney. In the research authors review current Banff diagnostic criteria used in kidney rejection, focus on their possible future evolution, and investigate the role of currently available molecular methods that could be implemented into the diagnostic scheme. Research also points out previously and currently available treatment methods applied to CA TCMR and takes into account possible side effects consequent upon the therapy. Moreover, attention is being paid to the CA TCMR coincidence with other kidney rejection types such as antibody-mediated rejection (ABMR) and its influence on the treatment approach. Authors also mark the possibility of non-HLA antibodies coexistence in patients with CA TCMR and describe its possible resonance on kidney allograft function. Nonetheless, it seems that current knowledge about CA TCMR is not sufficient and requires further investigation. MDPI 2022-12-19 /pmc/articles/PMC9777502/ /pubmed/36553226 http://dx.doi.org/10.3390/diagnostics12123220 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mizera, Jakub
Pilch, Justyna
Kamińska, Dorota
Krajewska, Magdalena
Donizy, Piotr
Banasik, Mirosław
Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss?
title Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss?
title_full Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss?
title_fullStr Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss?
title_full_unstemmed Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss?
title_short Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss?
title_sort chronic active t-cell mediated kidney rejection as a clinically significant type of allograft loss?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777502/
https://www.ncbi.nlm.nih.gov/pubmed/36553226
http://dx.doi.org/10.3390/diagnostics12123220
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