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Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss?
The purpose of this article is to assess the present knowledge about chronic active (CA) T-cell mediated rejection (TCMR) of a kidney. In the research authors review current Banff diagnostic criteria used in kidney rejection, focus on their possible future evolution, and investigate the role of curr...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777502/ https://www.ncbi.nlm.nih.gov/pubmed/36553226 http://dx.doi.org/10.3390/diagnostics12123220 |
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author | Mizera, Jakub Pilch, Justyna Kamińska, Dorota Krajewska, Magdalena Donizy, Piotr Banasik, Mirosław |
author_facet | Mizera, Jakub Pilch, Justyna Kamińska, Dorota Krajewska, Magdalena Donizy, Piotr Banasik, Mirosław |
author_sort | Mizera, Jakub |
collection | PubMed |
description | The purpose of this article is to assess the present knowledge about chronic active (CA) T-cell mediated rejection (TCMR) of a kidney. In the research authors review current Banff diagnostic criteria used in kidney rejection, focus on their possible future evolution, and investigate the role of currently available molecular methods that could be implemented into the diagnostic scheme. Research also points out previously and currently available treatment methods applied to CA TCMR and takes into account possible side effects consequent upon the therapy. Moreover, attention is being paid to the CA TCMR coincidence with other kidney rejection types such as antibody-mediated rejection (ABMR) and its influence on the treatment approach. Authors also mark the possibility of non-HLA antibodies coexistence in patients with CA TCMR and describe its possible resonance on kidney allograft function. Nonetheless, it seems that current knowledge about CA TCMR is not sufficient and requires further investigation. |
format | Online Article Text |
id | pubmed-9777502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97775022022-12-23 Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss? Mizera, Jakub Pilch, Justyna Kamińska, Dorota Krajewska, Magdalena Donizy, Piotr Banasik, Mirosław Diagnostics (Basel) Review The purpose of this article is to assess the present knowledge about chronic active (CA) T-cell mediated rejection (TCMR) of a kidney. In the research authors review current Banff diagnostic criteria used in kidney rejection, focus on their possible future evolution, and investigate the role of currently available molecular methods that could be implemented into the diagnostic scheme. Research also points out previously and currently available treatment methods applied to CA TCMR and takes into account possible side effects consequent upon the therapy. Moreover, attention is being paid to the CA TCMR coincidence with other kidney rejection types such as antibody-mediated rejection (ABMR) and its influence on the treatment approach. Authors also mark the possibility of non-HLA antibodies coexistence in patients with CA TCMR and describe its possible resonance on kidney allograft function. Nonetheless, it seems that current knowledge about CA TCMR is not sufficient and requires further investigation. MDPI 2022-12-19 /pmc/articles/PMC9777502/ /pubmed/36553226 http://dx.doi.org/10.3390/diagnostics12123220 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mizera, Jakub Pilch, Justyna Kamińska, Dorota Krajewska, Magdalena Donizy, Piotr Banasik, Mirosław Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss? |
title | Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss? |
title_full | Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss? |
title_fullStr | Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss? |
title_full_unstemmed | Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss? |
title_short | Chronic Active T-Cell Mediated Kidney Rejection as a Clinically Significant Type of Allograft Loss? |
title_sort | chronic active t-cell mediated kidney rejection as a clinically significant type of allograft loss? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777502/ https://www.ncbi.nlm.nih.gov/pubmed/36553226 http://dx.doi.org/10.3390/diagnostics12123220 |
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