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The Effect of Primary Aldosteronism on Carotid Artery Texture in Ultrasound Images

Primary aldosteronism (PA) is the most frequent cause of secondary hypertension. Early diagnoses of PA are essential to avoid the long-term negative effects of elevated aldosterone concentration on the cardiovascular and renal system. In this work, we study the texture of the carotid artery vessel w...

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Autores principales: Kaushik, Sumit, Majtan, Bohumil, Holaj, Robert, Baručić, Denis, Kološová, Barbora, Widimský, Jiří, Kybic, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777625/
https://www.ncbi.nlm.nih.gov/pubmed/36553213
http://dx.doi.org/10.3390/diagnostics12123206
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author Kaushik, Sumit
Majtan, Bohumil
Holaj, Robert
Baručić, Denis
Kološová, Barbora
Widimský, Jiří
Kybic, Jan
author_facet Kaushik, Sumit
Majtan, Bohumil
Holaj, Robert
Baručić, Denis
Kološová, Barbora
Widimský, Jiří
Kybic, Jan
author_sort Kaushik, Sumit
collection PubMed
description Primary aldosteronism (PA) is the most frequent cause of secondary hypertension. Early diagnoses of PA are essential to avoid the long-term negative effects of elevated aldosterone concentration on the cardiovascular and renal system. In this work, we study the texture of the carotid artery vessel wall from longitudinal ultrasound images in order to automatically distinguish between PA and essential hypertension (EH). The texture is characterized using 140 Haralick and 10 wavelet features evaluated in a region of interest in the vessel wall, followed by the XGBoost classifier. Carotid ultrasound studies were carried out on 33 patients aged 42–72 years with PA, 52 patients with EH, and 33 normotensive controls. For the most clinically relevant task of distinguishing PA and EH classes, we achieved a classification accuracy of 73% as assessed by a leave-one-out procedure. This result is promising even compared to the 57% prediction accuracy using clinical characteristics alone or 63% accuracy using a combination of clinical characteristics and intima-media thickness (IMT) parameters. If the accuracy is improved and the method incorporated into standard clinical procedures, this could eventually lead to an improvement in the early diagnosis of PA and consequently improve the clinical outcome for these patients in future.
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spelling pubmed-97776252022-12-23 The Effect of Primary Aldosteronism on Carotid Artery Texture in Ultrasound Images Kaushik, Sumit Majtan, Bohumil Holaj, Robert Baručić, Denis Kološová, Barbora Widimský, Jiří Kybic, Jan Diagnostics (Basel) Article Primary aldosteronism (PA) is the most frequent cause of secondary hypertension. Early diagnoses of PA are essential to avoid the long-term negative effects of elevated aldosterone concentration on the cardiovascular and renal system. In this work, we study the texture of the carotid artery vessel wall from longitudinal ultrasound images in order to automatically distinguish between PA and essential hypertension (EH). The texture is characterized using 140 Haralick and 10 wavelet features evaluated in a region of interest in the vessel wall, followed by the XGBoost classifier. Carotid ultrasound studies were carried out on 33 patients aged 42–72 years with PA, 52 patients with EH, and 33 normotensive controls. For the most clinically relevant task of distinguishing PA and EH classes, we achieved a classification accuracy of 73% as assessed by a leave-one-out procedure. This result is promising even compared to the 57% prediction accuracy using clinical characteristics alone or 63% accuracy using a combination of clinical characteristics and intima-media thickness (IMT) parameters. If the accuracy is improved and the method incorporated into standard clinical procedures, this could eventually lead to an improvement in the early diagnosis of PA and consequently improve the clinical outcome for these patients in future. MDPI 2022-12-17 /pmc/articles/PMC9777625/ /pubmed/36553213 http://dx.doi.org/10.3390/diagnostics12123206 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kaushik, Sumit
Majtan, Bohumil
Holaj, Robert
Baručić, Denis
Kološová, Barbora
Widimský, Jiří
Kybic, Jan
The Effect of Primary Aldosteronism on Carotid Artery Texture in Ultrasound Images
title The Effect of Primary Aldosteronism on Carotid Artery Texture in Ultrasound Images
title_full The Effect of Primary Aldosteronism on Carotid Artery Texture in Ultrasound Images
title_fullStr The Effect of Primary Aldosteronism on Carotid Artery Texture in Ultrasound Images
title_full_unstemmed The Effect of Primary Aldosteronism on Carotid Artery Texture in Ultrasound Images
title_short The Effect of Primary Aldosteronism on Carotid Artery Texture in Ultrasound Images
title_sort effect of primary aldosteronism on carotid artery texture in ultrasound images
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777625/
https://www.ncbi.nlm.nih.gov/pubmed/36553213
http://dx.doi.org/10.3390/diagnostics12123206
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