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Prediction of Masked Uncontrolled Hypertension Detected by Ambulatory Blood Pressure Monitoring

The aim of this study was to provide prediction models for masked uncontrolled hypertension (MUCH) detected by ambulatory blood pressure (BP) monitoring in an Italian population. We studied 738 treated hypertensive patients with normal clinic BPs classified as having controlled hypertension (CH) or...

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Autores principales: Coccina, Francesca, Borrelli, Paola, Pierdomenico, Anna M., Pizzicannella, Jacopo, Guagnano, Maria T., Cuccurullo, Chiara, Di Nicola, Marta, Renda, Giulia, Trubiani, Oriana, Cipollone, Francesco, Pierdomenico, Sante D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777728/
https://www.ncbi.nlm.nih.gov/pubmed/36553162
http://dx.doi.org/10.3390/diagnostics12123156
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author Coccina, Francesca
Borrelli, Paola
Pierdomenico, Anna M.
Pizzicannella, Jacopo
Guagnano, Maria T.
Cuccurullo, Chiara
Di Nicola, Marta
Renda, Giulia
Trubiani, Oriana
Cipollone, Francesco
Pierdomenico, Sante D.
author_facet Coccina, Francesca
Borrelli, Paola
Pierdomenico, Anna M.
Pizzicannella, Jacopo
Guagnano, Maria T.
Cuccurullo, Chiara
Di Nicola, Marta
Renda, Giulia
Trubiani, Oriana
Cipollone, Francesco
Pierdomenico, Sante D.
author_sort Coccina, Francesca
collection PubMed
description The aim of this study was to provide prediction models for masked uncontrolled hypertension (MUCH) detected by ambulatory blood pressure (BP) monitoring in an Italian population. We studied 738 treated hypertensive patients with normal clinic BPs classified as having controlled hypertension (CH) or MUCH if their daytime BP was < or ≥135/85 mmHg regardless of nighttime BP, respectively, or CH or MUCH if their 24-h BP was < or ≥130/80 mmHg regardless of daytime or nighttime BP, respectively. We detected 215 (29%) and 275 (37%) patients with MUCH using daytime and 24-h BP thresholds, respectively. Multivariate logistic regression analysis showed that males, those with a smoking habit, left ventricular hypertrophy (LVH), and a clinic systolic BP between 130–139 mmHg and/or clinic diastolic BP between 85–89 mmHg were associated with MUCH. The area under the receiver operating characteristic curve showed good accuracy at 0.78 (95% CI 0.75–0.81, p < 0.0001) and 0.77 (95% CI 0.73–0.80, p < 0.0001) for MUCH defined by daytime and 24 h BP, respectively. Internal validation suggested a good predictive performance of the models. Males, those with a smoking habit, LVH, and high-normal clinic BP are indicators of MUCH and models including these factors provide good diagnostic accuracy in identifying this ambulatory BP phenotype.
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spelling pubmed-97777282022-12-23 Prediction of Masked Uncontrolled Hypertension Detected by Ambulatory Blood Pressure Monitoring Coccina, Francesca Borrelli, Paola Pierdomenico, Anna M. Pizzicannella, Jacopo Guagnano, Maria T. Cuccurullo, Chiara Di Nicola, Marta Renda, Giulia Trubiani, Oriana Cipollone, Francesco Pierdomenico, Sante D. Diagnostics (Basel) Article The aim of this study was to provide prediction models for masked uncontrolled hypertension (MUCH) detected by ambulatory blood pressure (BP) monitoring in an Italian population. We studied 738 treated hypertensive patients with normal clinic BPs classified as having controlled hypertension (CH) or MUCH if their daytime BP was < or ≥135/85 mmHg regardless of nighttime BP, respectively, or CH or MUCH if their 24-h BP was < or ≥130/80 mmHg regardless of daytime or nighttime BP, respectively. We detected 215 (29%) and 275 (37%) patients with MUCH using daytime and 24-h BP thresholds, respectively. Multivariate logistic regression analysis showed that males, those with a smoking habit, left ventricular hypertrophy (LVH), and a clinic systolic BP between 130–139 mmHg and/or clinic diastolic BP between 85–89 mmHg were associated with MUCH. The area under the receiver operating characteristic curve showed good accuracy at 0.78 (95% CI 0.75–0.81, p < 0.0001) and 0.77 (95% CI 0.73–0.80, p < 0.0001) for MUCH defined by daytime and 24 h BP, respectively. Internal validation suggested a good predictive performance of the models. Males, those with a smoking habit, LVH, and high-normal clinic BP are indicators of MUCH and models including these factors provide good diagnostic accuracy in identifying this ambulatory BP phenotype. MDPI 2022-12-14 /pmc/articles/PMC9777728/ /pubmed/36553162 http://dx.doi.org/10.3390/diagnostics12123156 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Coccina, Francesca
Borrelli, Paola
Pierdomenico, Anna M.
Pizzicannella, Jacopo
Guagnano, Maria T.
Cuccurullo, Chiara
Di Nicola, Marta
Renda, Giulia
Trubiani, Oriana
Cipollone, Francesco
Pierdomenico, Sante D.
Prediction of Masked Uncontrolled Hypertension Detected by Ambulatory Blood Pressure Monitoring
title Prediction of Masked Uncontrolled Hypertension Detected by Ambulatory Blood Pressure Monitoring
title_full Prediction of Masked Uncontrolled Hypertension Detected by Ambulatory Blood Pressure Monitoring
title_fullStr Prediction of Masked Uncontrolled Hypertension Detected by Ambulatory Blood Pressure Monitoring
title_full_unstemmed Prediction of Masked Uncontrolled Hypertension Detected by Ambulatory Blood Pressure Monitoring
title_short Prediction of Masked Uncontrolled Hypertension Detected by Ambulatory Blood Pressure Monitoring
title_sort prediction of masked uncontrolled hypertension detected by ambulatory blood pressure monitoring
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777728/
https://www.ncbi.nlm.nih.gov/pubmed/36553162
http://dx.doi.org/10.3390/diagnostics12123156
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