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Efficacy of Wholistic Turmeric Supplement on Adenomatous Polyps in Patients with Familial Adenomatous Polyposis—A Randomized, Double-Blinded, Placebo-Controlled Study

Several studies have demonstrated that curcumin can cause the regression of polyps in familial adenomatous polyposis (FAP), while others have shown negative results. Wholistic turmeric (WT) containing curcumin and additional bioactive compounds may contribute to this effect. We performed a double-bl...

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Autores principales: Gilad, Ophir, Rosner, Guy, Ivancovsky-Wajcman, Dana, Zur, Reut, Rosin-Arbesfeld, Rina, Gluck, Nathan, Strul, Hana, Lehavi, Dana, Rolfe, Vivien, Kariv, Revital
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777742/
https://www.ncbi.nlm.nih.gov/pubmed/36553450
http://dx.doi.org/10.3390/genes13122182
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author Gilad, Ophir
Rosner, Guy
Ivancovsky-Wajcman, Dana
Zur, Reut
Rosin-Arbesfeld, Rina
Gluck, Nathan
Strul, Hana
Lehavi, Dana
Rolfe, Vivien
Kariv, Revital
author_facet Gilad, Ophir
Rosner, Guy
Ivancovsky-Wajcman, Dana
Zur, Reut
Rosin-Arbesfeld, Rina
Gluck, Nathan
Strul, Hana
Lehavi, Dana
Rolfe, Vivien
Kariv, Revital
author_sort Gilad, Ophir
collection PubMed
description Several studies have demonstrated that curcumin can cause the regression of polyps in familial adenomatous polyposis (FAP), while others have shown negative results. Wholistic turmeric (WT) containing curcumin and additional bioactive compounds may contribute to this effect. We performed a double-blinded, randomized, controlled trial to assess the efficacy of WT in FAP patients. Ten FAP patients were randomly assigned to receive either WT or placebo for 6 months. Colonoscopies were performed at baseline and after 6 months. The polyp number and size, as well as the cumulative polyp burden, were assessed. No differences were noted between the groups in terms of changes from the baseline’s polyp number, size, or burden. However, stratifying the data according to the right vs. left colon indicated a decrease in the median polyp number (from 5.5 to 1.5, p = 0.06) and polyp burden (from 24.25 mm to 11.5 mm, p = 0.028) in the left colon of the patients in the WT group. The adjusted left polyp number and burden in the WT arm were lower by 5.39 (p = 0.034) and 14.68 mm (p = 0.059), respectively. Whether WT can be used to reduce the polyp burden of patients with predominantly left-sided polyps remains to be seen; thus, further larger prospective trials are required.
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spelling pubmed-97777422022-12-23 Efficacy of Wholistic Turmeric Supplement on Adenomatous Polyps in Patients with Familial Adenomatous Polyposis—A Randomized, Double-Blinded, Placebo-Controlled Study Gilad, Ophir Rosner, Guy Ivancovsky-Wajcman, Dana Zur, Reut Rosin-Arbesfeld, Rina Gluck, Nathan Strul, Hana Lehavi, Dana Rolfe, Vivien Kariv, Revital Genes (Basel) Article Several studies have demonstrated that curcumin can cause the regression of polyps in familial adenomatous polyposis (FAP), while others have shown negative results. Wholistic turmeric (WT) containing curcumin and additional bioactive compounds may contribute to this effect. We performed a double-blinded, randomized, controlled trial to assess the efficacy of WT in FAP patients. Ten FAP patients were randomly assigned to receive either WT or placebo for 6 months. Colonoscopies were performed at baseline and after 6 months. The polyp number and size, as well as the cumulative polyp burden, were assessed. No differences were noted between the groups in terms of changes from the baseline’s polyp number, size, or burden. However, stratifying the data according to the right vs. left colon indicated a decrease in the median polyp number (from 5.5 to 1.5, p = 0.06) and polyp burden (from 24.25 mm to 11.5 mm, p = 0.028) in the left colon of the patients in the WT group. The adjusted left polyp number and burden in the WT arm were lower by 5.39 (p = 0.034) and 14.68 mm (p = 0.059), respectively. Whether WT can be used to reduce the polyp burden of patients with predominantly left-sided polyps remains to be seen; thus, further larger prospective trials are required. MDPI 2022-11-22 /pmc/articles/PMC9777742/ /pubmed/36553450 http://dx.doi.org/10.3390/genes13122182 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gilad, Ophir
Rosner, Guy
Ivancovsky-Wajcman, Dana
Zur, Reut
Rosin-Arbesfeld, Rina
Gluck, Nathan
Strul, Hana
Lehavi, Dana
Rolfe, Vivien
Kariv, Revital
Efficacy of Wholistic Turmeric Supplement on Adenomatous Polyps in Patients with Familial Adenomatous Polyposis—A Randomized, Double-Blinded, Placebo-Controlled Study
title Efficacy of Wholistic Turmeric Supplement on Adenomatous Polyps in Patients with Familial Adenomatous Polyposis—A Randomized, Double-Blinded, Placebo-Controlled Study
title_full Efficacy of Wholistic Turmeric Supplement on Adenomatous Polyps in Patients with Familial Adenomatous Polyposis—A Randomized, Double-Blinded, Placebo-Controlled Study
title_fullStr Efficacy of Wholistic Turmeric Supplement on Adenomatous Polyps in Patients with Familial Adenomatous Polyposis—A Randomized, Double-Blinded, Placebo-Controlled Study
title_full_unstemmed Efficacy of Wholistic Turmeric Supplement on Adenomatous Polyps in Patients with Familial Adenomatous Polyposis—A Randomized, Double-Blinded, Placebo-Controlled Study
title_short Efficacy of Wholistic Turmeric Supplement on Adenomatous Polyps in Patients with Familial Adenomatous Polyposis—A Randomized, Double-Blinded, Placebo-Controlled Study
title_sort efficacy of wholistic turmeric supplement on adenomatous polyps in patients with familial adenomatous polyposis—a randomized, double-blinded, placebo-controlled study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777742/
https://www.ncbi.nlm.nih.gov/pubmed/36553450
http://dx.doi.org/10.3390/genes13122182
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