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Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold
Hydrolyzed hyaluronic acid high-resolution fine microneedles of 13 µm in diameter and 24 µm in height were fabricated from hydrolyzed hyaluronic acid gels made in mixtures of water using vacuum environment imprint lithography processes with a water permeable mold. The gas traps of water and volatile...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777786/ https://www.ncbi.nlm.nih.gov/pubmed/36547309 http://dx.doi.org/10.3390/gels8120785 |
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author | Miura, Sayaka Yamagishi, Rio Miyazaki, Riku Yasuda, Kaori Kawano, Yuki Yokoyama, Yoshiyuki Sugino, Naoto Kameda, Takao Takei, Satoshi |
author_facet | Miura, Sayaka Yamagishi, Rio Miyazaki, Riku Yasuda, Kaori Kawano, Yuki Yokoyama, Yoshiyuki Sugino, Naoto Kameda, Takao Takei, Satoshi |
author_sort | Miura, Sayaka |
collection | PubMed |
description | Hydrolyzed hyaluronic acid high-resolution fine microneedles of 13 µm in diameter and 24 µm in height were fabricated from hydrolyzed hyaluronic acid gels made in mixtures of water using vacuum environment imprint lithography processes with a water permeable mold. The gas traps of water and volatile solvents in the imprint materials cause transfer failure in the conventional water impermeable molds of quartz and metal. However, the water permeable mold allows the use of 67 wt% dilution water with high solubility to increase the fluidity of the hydrolyzed hyaluronic acid during the patterning of high-resolution fine microneedles for cosmetics and pharmaceuticals. This demonstration sets a new paradigm of functional pure gels for high-resolution nano-patterning applications with various cosmetic and pharmaceutical materials containing dilution water using a water permeable mold. |
format | Online Article Text |
id | pubmed-9777786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97777862022-12-23 Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold Miura, Sayaka Yamagishi, Rio Miyazaki, Riku Yasuda, Kaori Kawano, Yuki Yokoyama, Yoshiyuki Sugino, Naoto Kameda, Takao Takei, Satoshi Gels Communication Hydrolyzed hyaluronic acid high-resolution fine microneedles of 13 µm in diameter and 24 µm in height were fabricated from hydrolyzed hyaluronic acid gels made in mixtures of water using vacuum environment imprint lithography processes with a water permeable mold. The gas traps of water and volatile solvents in the imprint materials cause transfer failure in the conventional water impermeable molds of quartz and metal. However, the water permeable mold allows the use of 67 wt% dilution water with high solubility to increase the fluidity of the hydrolyzed hyaluronic acid during the patterning of high-resolution fine microneedles for cosmetics and pharmaceuticals. This demonstration sets a new paradigm of functional pure gels for high-resolution nano-patterning applications with various cosmetic and pharmaceutical materials containing dilution water using a water permeable mold. MDPI 2022-11-29 /pmc/articles/PMC9777786/ /pubmed/36547309 http://dx.doi.org/10.3390/gels8120785 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Miura, Sayaka Yamagishi, Rio Miyazaki, Riku Yasuda, Kaori Kawano, Yuki Yokoyama, Yoshiyuki Sugino, Naoto Kameda, Takao Takei, Satoshi Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold |
title | Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold |
title_full | Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold |
title_fullStr | Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold |
title_full_unstemmed | Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold |
title_short | Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold |
title_sort | fabrication of high-resolution fine microneedles derived from hydrolyzed hyaluronic acid gels in vacuum environment imprinting using water permeable mold |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777786/ https://www.ncbi.nlm.nih.gov/pubmed/36547309 http://dx.doi.org/10.3390/gels8120785 |
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