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Universal Strategy for Designing Shape Memory Hydrogels
[Image: see text] Smart polymeric biomaterials have been the focus of many recent biomedical studies, especially those with adaptability to defects and potential to be implanted in the human body. Herein we report a versatile and straightforward method to convert non-thermoresponsive hydrogels into...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777886/ https://www.ncbi.nlm.nih.gov/pubmed/36568348 http://dx.doi.org/10.1021/acsmaterialslett.2c00107 |
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author | Costa, Dora C. S. Costa, Patrícia D. C. Gomes, Maria C. Chandrakar, Amit Wieringa, Paul A. Moroni, Lorenzo Mano, João F. |
author_facet | Costa, Dora C. S. Costa, Patrícia D. C. Gomes, Maria C. Chandrakar, Amit Wieringa, Paul A. Moroni, Lorenzo Mano, João F. |
author_sort | Costa, Dora C. S. |
collection | PubMed |
description | [Image: see text] Smart polymeric biomaterials have been the focus of many recent biomedical studies, especially those with adaptability to defects and potential to be implanted in the human body. Herein we report a versatile and straightforward method to convert non-thermoresponsive hydrogels into thermoresponsive systems with shape memory ability. As a proof of concept, a thermoresponsive polyurethane mesh was embedded within a methacrylated chitosan (CHTMA), gelatin (GELMA), laminarin (LAMMA) or hyaluronic acid (HAMA) hydrogel network, which afforded hydrogel composites with shape memory ability. With this system, we achieved good to excellent shape fixity ratios (50–90%) and excellent shape recovery ratios (∼100%, almost instantaneously) at body temperature (37 °C). Cytocompatibility tests demonstrated good viability either with cells on top or encapsulated during all shape memory processes. This straightforward approach opens a broad range of possibilities to convey shape memory properties to virtually any synthetic or natural-based hydrogel for several biological and nonbiological applications. |
format | Online Article Text |
id | pubmed-9777886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-97778862022-12-23 Universal Strategy for Designing Shape Memory Hydrogels Costa, Dora C. S. Costa, Patrícia D. C. Gomes, Maria C. Chandrakar, Amit Wieringa, Paul A. Moroni, Lorenzo Mano, João F. ACS Mater Lett [Image: see text] Smart polymeric biomaterials have been the focus of many recent biomedical studies, especially those with adaptability to defects and potential to be implanted in the human body. Herein we report a versatile and straightforward method to convert non-thermoresponsive hydrogels into thermoresponsive systems with shape memory ability. As a proof of concept, a thermoresponsive polyurethane mesh was embedded within a methacrylated chitosan (CHTMA), gelatin (GELMA), laminarin (LAMMA) or hyaluronic acid (HAMA) hydrogel network, which afforded hydrogel composites with shape memory ability. With this system, we achieved good to excellent shape fixity ratios (50–90%) and excellent shape recovery ratios (∼100%, almost instantaneously) at body temperature (37 °C). Cytocompatibility tests demonstrated good viability either with cells on top or encapsulated during all shape memory processes. This straightforward approach opens a broad range of possibilities to convey shape memory properties to virtually any synthetic or natural-based hydrogel for several biological and nonbiological applications. American Chemical Society 2022-03-10 2022-04-04 /pmc/articles/PMC9777886/ /pubmed/36568348 http://dx.doi.org/10.1021/acsmaterialslett.2c00107 Text en © 2022 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Costa, Dora C. S. Costa, Patrícia D. C. Gomes, Maria C. Chandrakar, Amit Wieringa, Paul A. Moroni, Lorenzo Mano, João F. Universal Strategy for Designing Shape Memory Hydrogels |
title | Universal Strategy for Designing Shape Memory Hydrogels |
title_full | Universal Strategy for Designing Shape Memory Hydrogels |
title_fullStr | Universal Strategy for Designing Shape Memory Hydrogels |
title_full_unstemmed | Universal Strategy for Designing Shape Memory Hydrogels |
title_short | Universal Strategy for Designing Shape Memory Hydrogels |
title_sort | universal strategy for designing shape memory hydrogels |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777886/ https://www.ncbi.nlm.nih.gov/pubmed/36568348 http://dx.doi.org/10.1021/acsmaterialslett.2c00107 |
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