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Mapping HPV 16 Sub-Lineages in Anal Cancer and Implications for Disease Outcomes

The incidence of anal cancer is rising worldwide. As identified in cervical cancer management, an improvement in the early detection and management of anal pre-cancer is essential. In other cancers associated with human papillomavirus (HPV), HPV 16 sub-lineages have been shown to be associated with...

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Autores principales: Guerendiain, Daniel, Mühr, Laila Sara Arroyo, Grigorescu, Raluca, Holden, Matthew T. G., Cuschieri, Kate
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777971/
https://www.ncbi.nlm.nih.gov/pubmed/36553229
http://dx.doi.org/10.3390/diagnostics12123222
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author Guerendiain, Daniel
Mühr, Laila Sara Arroyo
Grigorescu, Raluca
Holden, Matthew T. G.
Cuschieri, Kate
author_facet Guerendiain, Daniel
Mühr, Laila Sara Arroyo
Grigorescu, Raluca
Holden, Matthew T. G.
Cuschieri, Kate
author_sort Guerendiain, Daniel
collection PubMed
description The incidence of anal cancer is rising worldwide. As identified in cervical cancer management, an improvement in the early detection and management of anal pre-cancer is essential. In other cancers associated with human papillomavirus (HPV), HPV 16 sub-lineages have been shown to be associated with disease status and prognosis. However, in anal cancer, they have been under-explored. A total of 119 HPV 16-positive anal cancer lesions diagnosed between 2009 and 2018 in Scotland and 134 HPV 16-positive residual rectal swabs from asymptomatic men collected in 2016/7 were whole genome sequenced. The association of HPV 16 sub-lineages with underlying disease status (cancer vs. asymptomatic) and overall survival in anal cancer samples was assessed (comparing A1 vs non-A1 sub-lineages). A1 was the dominant sub-lineage present in the anal cancer (76.5%) and the asymptomatic (76.1%) cohorts. A2 was the second most dominant sub-lineage in both groups (16.8% and 17.2%, respectively). We did not observe significant associations of sub-lineage with demographics, clinical variables or survival (A1 vs. non-A1 sub-lineages (HR 0.83, 0.28–2.46 p = 0.743)). HPV 16 sub-lineages do to not appear to cluster with disease vs asymptomatic carriage or be independently associated with outcomes in anal cancer patients. Further international studies on anal HPV sub-lineage mapping will help to determine whether this is a consistent observation.
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spelling pubmed-97779712022-12-23 Mapping HPV 16 Sub-Lineages in Anal Cancer and Implications for Disease Outcomes Guerendiain, Daniel Mühr, Laila Sara Arroyo Grigorescu, Raluca Holden, Matthew T. G. Cuschieri, Kate Diagnostics (Basel) Article The incidence of anal cancer is rising worldwide. As identified in cervical cancer management, an improvement in the early detection and management of anal pre-cancer is essential. In other cancers associated with human papillomavirus (HPV), HPV 16 sub-lineages have been shown to be associated with disease status and prognosis. However, in anal cancer, they have been under-explored. A total of 119 HPV 16-positive anal cancer lesions diagnosed between 2009 and 2018 in Scotland and 134 HPV 16-positive residual rectal swabs from asymptomatic men collected in 2016/7 were whole genome sequenced. The association of HPV 16 sub-lineages with underlying disease status (cancer vs. asymptomatic) and overall survival in anal cancer samples was assessed (comparing A1 vs non-A1 sub-lineages). A1 was the dominant sub-lineage present in the anal cancer (76.5%) and the asymptomatic (76.1%) cohorts. A2 was the second most dominant sub-lineage in both groups (16.8% and 17.2%, respectively). We did not observe significant associations of sub-lineage with demographics, clinical variables or survival (A1 vs. non-A1 sub-lineages (HR 0.83, 0.28–2.46 p = 0.743)). HPV 16 sub-lineages do to not appear to cluster with disease vs asymptomatic carriage or be independently associated with outcomes in anal cancer patients. Further international studies on anal HPV sub-lineage mapping will help to determine whether this is a consistent observation. MDPI 2022-12-19 /pmc/articles/PMC9777971/ /pubmed/36553229 http://dx.doi.org/10.3390/diagnostics12123222 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Guerendiain, Daniel
Mühr, Laila Sara Arroyo
Grigorescu, Raluca
Holden, Matthew T. G.
Cuschieri, Kate
Mapping HPV 16 Sub-Lineages in Anal Cancer and Implications for Disease Outcomes
title Mapping HPV 16 Sub-Lineages in Anal Cancer and Implications for Disease Outcomes
title_full Mapping HPV 16 Sub-Lineages in Anal Cancer and Implications for Disease Outcomes
title_fullStr Mapping HPV 16 Sub-Lineages in Anal Cancer and Implications for Disease Outcomes
title_full_unstemmed Mapping HPV 16 Sub-Lineages in Anal Cancer and Implications for Disease Outcomes
title_short Mapping HPV 16 Sub-Lineages in Anal Cancer and Implications for Disease Outcomes
title_sort mapping hpv 16 sub-lineages in anal cancer and implications for disease outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777971/
https://www.ncbi.nlm.nih.gov/pubmed/36553229
http://dx.doi.org/10.3390/diagnostics12123222
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