Genetic Polymorphisms of Cytochromes P450 in Finno-Permic Populations of Russia

Cytochrome P450 is an enzyme involved in the metabolism of phase 1 xenobiotics, toxins, endogenous hormones, and drugs, including those used in COVID-19 treatment. Cytochrome p450 genes are linked to the pathogenesis of some multifactorial traits and diseases, such as cancer, particularly prostate c...

Descripción completa

Detalles Bibliográficos
Autores principales: Dzhaubermezov, Murat, Ekomasova, Natalya, Mustafin, Rustam, Gabidullina, Lilia, Galimova, Yuliya, Nurgalieva, Alfiya, Valova, Yana, Prokofyeva, Darya, Khusnutdinova, Elza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777976/
https://www.ncbi.nlm.nih.gov/pubmed/36553620
http://dx.doi.org/10.3390/genes13122353
Descripción
Sumario:Cytochrome P450 is an enzyme involved in the metabolism of phase 1 xenobiotics, toxins, endogenous hormones, and drugs, including those used in COVID-19 treatment. Cytochrome p450 genes are linked to the pathogenesis of some multifactorial traits and diseases, such as cancer, particularly prostate cancer, colorectal cancer, breast cancer, and cervical cancer. Genotyping was performed on 540 supposedly healthy individuals of 5 Finno-Permic populations from the territories of the European part of the Russian Federation. There was a statistically significant difference between Veps and most of the studied populations in the rs4986774 locus of the CYP2D6 gene; data on the rs3892097 locus of the CYP2D6 gene shows that Izhemsky Komis are different from the Mordovian and Udmurt populations.

Ejemplares similares