Genetic Polymorphisms of Cytochromes P450 in Finno-Permic Populations of Russia

Cytochrome P450 is an enzyme involved in the metabolism of phase 1 xenobiotics, toxins, endogenous hormones, and drugs, including those used in COVID-19 treatment. Cytochrome p450 genes are linked to the pathogenesis of some multifactorial traits and diseases, such as cancer, particularly prostate c...

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Autores principales: Dzhaubermezov, Murat, Ekomasova, Natalya, Mustafin, Rustam, Gabidullina, Lilia, Galimova, Yuliya, Nurgalieva, Alfiya, Valova, Yana, Prokofyeva, Darya, Khusnutdinova, Elza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777976/
https://www.ncbi.nlm.nih.gov/pubmed/36553620
http://dx.doi.org/10.3390/genes13122353
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author Dzhaubermezov, Murat
Ekomasova, Natalya
Mustafin, Rustam
Gabidullina, Lilia
Galimova, Yuliya
Nurgalieva, Alfiya
Valova, Yana
Prokofyeva, Darya
Khusnutdinova, Elza
author_facet Dzhaubermezov, Murat
Ekomasova, Natalya
Mustafin, Rustam
Gabidullina, Lilia
Galimova, Yuliya
Nurgalieva, Alfiya
Valova, Yana
Prokofyeva, Darya
Khusnutdinova, Elza
author_sort Dzhaubermezov, Murat
collection PubMed
description Cytochrome P450 is an enzyme involved in the metabolism of phase 1 xenobiotics, toxins, endogenous hormones, and drugs, including those used in COVID-19 treatment. Cytochrome p450 genes are linked to the pathogenesis of some multifactorial traits and diseases, such as cancer, particularly prostate cancer, colorectal cancer, breast cancer, and cervical cancer. Genotyping was performed on 540 supposedly healthy individuals of 5 Finno-Permic populations from the territories of the European part of the Russian Federation. There was a statistically significant difference between Veps and most of the studied populations in the rs4986774 locus of the CYP2D6 gene; data on the rs3892097 locus of the CYP2D6 gene shows that Izhemsky Komis are different from the Mordovian and Udmurt populations.
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spelling pubmed-97779762022-12-23 Genetic Polymorphisms of Cytochromes P450 in Finno-Permic Populations of Russia Dzhaubermezov, Murat Ekomasova, Natalya Mustafin, Rustam Gabidullina, Lilia Galimova, Yuliya Nurgalieva, Alfiya Valova, Yana Prokofyeva, Darya Khusnutdinova, Elza Genes (Basel) Article Cytochrome P450 is an enzyme involved in the metabolism of phase 1 xenobiotics, toxins, endogenous hormones, and drugs, including those used in COVID-19 treatment. Cytochrome p450 genes are linked to the pathogenesis of some multifactorial traits and diseases, such as cancer, particularly prostate cancer, colorectal cancer, breast cancer, and cervical cancer. Genotyping was performed on 540 supposedly healthy individuals of 5 Finno-Permic populations from the territories of the European part of the Russian Federation. There was a statistically significant difference between Veps and most of the studied populations in the rs4986774 locus of the CYP2D6 gene; data on the rs3892097 locus of the CYP2D6 gene shows that Izhemsky Komis are different from the Mordovian and Udmurt populations. MDPI 2022-12-13 /pmc/articles/PMC9777976/ /pubmed/36553620 http://dx.doi.org/10.3390/genes13122353 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dzhaubermezov, Murat
Ekomasova, Natalya
Mustafin, Rustam
Gabidullina, Lilia
Galimova, Yuliya
Nurgalieva, Alfiya
Valova, Yana
Prokofyeva, Darya
Khusnutdinova, Elza
Genetic Polymorphisms of Cytochromes P450 in Finno-Permic Populations of Russia
title Genetic Polymorphisms of Cytochromes P450 in Finno-Permic Populations of Russia
title_full Genetic Polymorphisms of Cytochromes P450 in Finno-Permic Populations of Russia
title_fullStr Genetic Polymorphisms of Cytochromes P450 in Finno-Permic Populations of Russia
title_full_unstemmed Genetic Polymorphisms of Cytochromes P450 in Finno-Permic Populations of Russia
title_short Genetic Polymorphisms of Cytochromes P450 in Finno-Permic Populations of Russia
title_sort genetic polymorphisms of cytochromes p450 in finno-permic populations of russia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9777976/
https://www.ncbi.nlm.nih.gov/pubmed/36553620
http://dx.doi.org/10.3390/genes13122353
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