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Piezoelectric and Magnetically Responsive Biodegradable Composites with Tailored Porous Morphology for Biotechnological Applications

[Image: see text] The biomedical area in the scope of tissue regeneration pursues the development of advanced materials that can target biomimetic approaches and, ideally, have an active role in the environment they are placed in. This active role can be related to or driven by morphological, mechan...

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Autores principales: Marques-Almeida, Teresa, Correia, Vitor, Fernández Martín, Eduardo, García Díez, Ander, Ribeiro, Clarisse, Lanceros-Mendez, Senentxu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778034/
https://www.ncbi.nlm.nih.gov/pubmed/36570789
http://dx.doi.org/10.1021/acsapm.2c01114
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author Marques-Almeida, Teresa
Correia, Vitor
Fernández Martín, Eduardo
García Díez, Ander
Ribeiro, Clarisse
Lanceros-Mendez, Senentxu
author_facet Marques-Almeida, Teresa
Correia, Vitor
Fernández Martín, Eduardo
García Díez, Ander
Ribeiro, Clarisse
Lanceros-Mendez, Senentxu
author_sort Marques-Almeida, Teresa
collection PubMed
description [Image: see text] The biomedical area in the scope of tissue regeneration pursues the development of advanced materials that can target biomimetic approaches and, ideally, have an active role in the environment they are placed in. This active role can be related to or driven by morphological, mechanical, electrical, or magnetic stimuli, among others. This work reports on the development of active biomaterials based on poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid), PHBV, a piezoelectric and biodegradable polymer, for tissue regeneration application by tailoring its morphology and functional response. PHBV films with different porosities were obtained using the solvent casting method, resorting to high-boiling-point solvents, as N,N-dimethylformamide (DMF) and dimethylsulfoxide (DMSO), and the combination of chloroform (CF) and DMF for polymer dissolution. Furthermore, magnetoelectric biomaterials were obtained through the combination of the piezoelectric PHBV with magnetostrictive iron oxide (Fe(3)O(4)) nanoparticles. Independently of the morphology or filler content, all biomaterials proved to be suitable for biomedical applications.
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spelling pubmed-97780342022-12-23 Piezoelectric and Magnetically Responsive Biodegradable Composites with Tailored Porous Morphology for Biotechnological Applications Marques-Almeida, Teresa Correia, Vitor Fernández Martín, Eduardo García Díez, Ander Ribeiro, Clarisse Lanceros-Mendez, Senentxu ACS Appl Polym Mater [Image: see text] The biomedical area in the scope of tissue regeneration pursues the development of advanced materials that can target biomimetic approaches and, ideally, have an active role in the environment they are placed in. This active role can be related to or driven by morphological, mechanical, electrical, or magnetic stimuli, among others. This work reports on the development of active biomaterials based on poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid), PHBV, a piezoelectric and biodegradable polymer, for tissue regeneration application by tailoring its morphology and functional response. PHBV films with different porosities were obtained using the solvent casting method, resorting to high-boiling-point solvents, as N,N-dimethylformamide (DMF) and dimethylsulfoxide (DMSO), and the combination of chloroform (CF) and DMF for polymer dissolution. Furthermore, magnetoelectric biomaterials were obtained through the combination of the piezoelectric PHBV with magnetostrictive iron oxide (Fe(3)O(4)) nanoparticles. Independently of the morphology or filler content, all biomaterials proved to be suitable for biomedical applications. American Chemical Society 2022-11-09 2022-12-09 /pmc/articles/PMC9778034/ /pubmed/36570789 http://dx.doi.org/10.1021/acsapm.2c01114 Text en © 2022 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Marques-Almeida, Teresa
Correia, Vitor
Fernández Martín, Eduardo
García Díez, Ander
Ribeiro, Clarisse
Lanceros-Mendez, Senentxu
Piezoelectric and Magnetically Responsive Biodegradable Composites with Tailored Porous Morphology for Biotechnological Applications
title Piezoelectric and Magnetically Responsive Biodegradable Composites with Tailored Porous Morphology for Biotechnological Applications
title_full Piezoelectric and Magnetically Responsive Biodegradable Composites with Tailored Porous Morphology for Biotechnological Applications
title_fullStr Piezoelectric and Magnetically Responsive Biodegradable Composites with Tailored Porous Morphology for Biotechnological Applications
title_full_unstemmed Piezoelectric and Magnetically Responsive Biodegradable Composites with Tailored Porous Morphology for Biotechnological Applications
title_short Piezoelectric and Magnetically Responsive Biodegradable Composites with Tailored Porous Morphology for Biotechnological Applications
title_sort piezoelectric and magnetically responsive biodegradable composites with tailored porous morphology for biotechnological applications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778034/
https://www.ncbi.nlm.nih.gov/pubmed/36570789
http://dx.doi.org/10.1021/acsapm.2c01114
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