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Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study

We assessed the association between polypharmacy and cardiovascular autonomic function among community-dwelling elderly patients having chronic diseases. Three hundred and twenty-one patients from an urban municipality area of Kolkata, India were studied in August 2022. The anticholinergic burden an...

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Autores principales: Samajdar, Shambo Samrat, Das, Saibal, Sarkar, Sougata, Mukherjee, Shatavisa, Pathak, Ashish, Stålsby Lundborg, Cecilia, Saha, Indranil, Tripathi, Santanu Kumar, Pal, Jyotirmoy, Chatterjee, Nandini, Joshi, Shashank R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778147/
https://www.ncbi.nlm.nih.gov/pubmed/36547272
http://dx.doi.org/10.3390/geriatrics7060136
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author Samajdar, Shambo Samrat
Das, Saibal
Sarkar, Sougata
Mukherjee, Shatavisa
Pathak, Ashish
Stålsby Lundborg, Cecilia
Saha, Indranil
Tripathi, Santanu Kumar
Pal, Jyotirmoy
Chatterjee, Nandini
Joshi, Shashank R
author_facet Samajdar, Shambo Samrat
Das, Saibal
Sarkar, Sougata
Mukherjee, Shatavisa
Pathak, Ashish
Stålsby Lundborg, Cecilia
Saha, Indranil
Tripathi, Santanu Kumar
Pal, Jyotirmoy
Chatterjee, Nandini
Joshi, Shashank R
author_sort Samajdar, Shambo Samrat
collection PubMed
description We assessed the association between polypharmacy and cardiovascular autonomic function among community-dwelling elderly patients having chronic diseases. Three hundred and twenty-one patients from an urban municipality area of Kolkata, India were studied in August 2022. The anticholinergic burden and cardiac autonomic function (Valsalva ratio, orthostatic hypotension, change in diastolic blood pressure after an isometric exercise, and heart rate variability during expiration and inspiration) were evaluated. Binary logistic regression analysis was performed to find out the association of polypharmacy and total anticholinergic burden with cardiac autonomic neuropathy. A total of 305 patients (age, 68.9 ± 3.4; 65.9% male) were included. Of these patients, 81 (26.6%) were on polypharmacy. Out of these 81 patients, 42 patients were on ninety-eight potential inappropriate medications. The anticholinergic burden and the proportion of patients with cardiac autonomic neuropathy were significantly higher among patients who were on polypharmacy than those who were not (8.1 ± 2.3 vs. 2.3 ± 0.9; p = 0.03 and 56.8% vs. 44.6%; p = 0.01). The presence of polypharmacy and a total anticholinergic burden of > 3 was significantly associated with cardiac autonomic neuropathy (aOR, 2.66; 95% CI, 0.91–3.98 and aOR, 2.51; 95% CI, 0.99–3.52, respectively). Thus, polypharmacy was significantly associated with cardiac autonomic neuropathy among community-dwelling elderly patients.
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spelling pubmed-97781472022-12-23 Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study Samajdar, Shambo Samrat Das, Saibal Sarkar, Sougata Mukherjee, Shatavisa Pathak, Ashish Stålsby Lundborg, Cecilia Saha, Indranil Tripathi, Santanu Kumar Pal, Jyotirmoy Chatterjee, Nandini Joshi, Shashank R Geriatrics (Basel) Article We assessed the association between polypharmacy and cardiovascular autonomic function among community-dwelling elderly patients having chronic diseases. Three hundred and twenty-one patients from an urban municipality area of Kolkata, India were studied in August 2022. The anticholinergic burden and cardiac autonomic function (Valsalva ratio, orthostatic hypotension, change in diastolic blood pressure after an isometric exercise, and heart rate variability during expiration and inspiration) were evaluated. Binary logistic regression analysis was performed to find out the association of polypharmacy and total anticholinergic burden with cardiac autonomic neuropathy. A total of 305 patients (age, 68.9 ± 3.4; 65.9% male) were included. Of these patients, 81 (26.6%) were on polypharmacy. Out of these 81 patients, 42 patients were on ninety-eight potential inappropriate medications. The anticholinergic burden and the proportion of patients with cardiac autonomic neuropathy were significantly higher among patients who were on polypharmacy than those who were not (8.1 ± 2.3 vs. 2.3 ± 0.9; p = 0.03 and 56.8% vs. 44.6%; p = 0.01). The presence of polypharmacy and a total anticholinergic burden of > 3 was significantly associated with cardiac autonomic neuropathy (aOR, 2.66; 95% CI, 0.91–3.98 and aOR, 2.51; 95% CI, 0.99–3.52, respectively). Thus, polypharmacy was significantly associated with cardiac autonomic neuropathy among community-dwelling elderly patients. MDPI 2022-11-29 /pmc/articles/PMC9778147/ /pubmed/36547272 http://dx.doi.org/10.3390/geriatrics7060136 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Samajdar, Shambo Samrat
Das, Saibal
Sarkar, Sougata
Mukherjee, Shatavisa
Pathak, Ashish
Stålsby Lundborg, Cecilia
Saha, Indranil
Tripathi, Santanu Kumar
Pal, Jyotirmoy
Chatterjee, Nandini
Joshi, Shashank R
Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study
title Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study
title_full Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study
title_fullStr Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study
title_full_unstemmed Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study
title_short Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study
title_sort association between polypharmacy and cardiovascular autonomic function among elderly patients in an urban municipality area of kolkata, india: a record-based cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778147/
https://www.ncbi.nlm.nih.gov/pubmed/36547272
http://dx.doi.org/10.3390/geriatrics7060136
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