Cargando…
Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study
We assessed the association between polypharmacy and cardiovascular autonomic function among community-dwelling elderly patients having chronic diseases. Three hundred and twenty-one patients from an urban municipality area of Kolkata, India were studied in August 2022. The anticholinergic burden an...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778147/ https://www.ncbi.nlm.nih.gov/pubmed/36547272 http://dx.doi.org/10.3390/geriatrics7060136 |
_version_ | 1784856286065590272 |
---|---|
author | Samajdar, Shambo Samrat Das, Saibal Sarkar, Sougata Mukherjee, Shatavisa Pathak, Ashish Stålsby Lundborg, Cecilia Saha, Indranil Tripathi, Santanu Kumar Pal, Jyotirmoy Chatterjee, Nandini Joshi, Shashank R |
author_facet | Samajdar, Shambo Samrat Das, Saibal Sarkar, Sougata Mukherjee, Shatavisa Pathak, Ashish Stålsby Lundborg, Cecilia Saha, Indranil Tripathi, Santanu Kumar Pal, Jyotirmoy Chatterjee, Nandini Joshi, Shashank R |
author_sort | Samajdar, Shambo Samrat |
collection | PubMed |
description | We assessed the association between polypharmacy and cardiovascular autonomic function among community-dwelling elderly patients having chronic diseases. Three hundred and twenty-one patients from an urban municipality area of Kolkata, India were studied in August 2022. The anticholinergic burden and cardiac autonomic function (Valsalva ratio, orthostatic hypotension, change in diastolic blood pressure after an isometric exercise, and heart rate variability during expiration and inspiration) were evaluated. Binary logistic regression analysis was performed to find out the association of polypharmacy and total anticholinergic burden with cardiac autonomic neuropathy. A total of 305 patients (age, 68.9 ± 3.4; 65.9% male) were included. Of these patients, 81 (26.6%) were on polypharmacy. Out of these 81 patients, 42 patients were on ninety-eight potential inappropriate medications. The anticholinergic burden and the proportion of patients with cardiac autonomic neuropathy were significantly higher among patients who were on polypharmacy than those who were not (8.1 ± 2.3 vs. 2.3 ± 0.9; p = 0.03 and 56.8% vs. 44.6%; p = 0.01). The presence of polypharmacy and a total anticholinergic burden of > 3 was significantly associated with cardiac autonomic neuropathy (aOR, 2.66; 95% CI, 0.91–3.98 and aOR, 2.51; 95% CI, 0.99–3.52, respectively). Thus, polypharmacy was significantly associated with cardiac autonomic neuropathy among community-dwelling elderly patients. |
format | Online Article Text |
id | pubmed-9778147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97781472022-12-23 Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study Samajdar, Shambo Samrat Das, Saibal Sarkar, Sougata Mukherjee, Shatavisa Pathak, Ashish Stålsby Lundborg, Cecilia Saha, Indranil Tripathi, Santanu Kumar Pal, Jyotirmoy Chatterjee, Nandini Joshi, Shashank R Geriatrics (Basel) Article We assessed the association between polypharmacy and cardiovascular autonomic function among community-dwelling elderly patients having chronic diseases. Three hundred and twenty-one patients from an urban municipality area of Kolkata, India were studied in August 2022. The anticholinergic burden and cardiac autonomic function (Valsalva ratio, orthostatic hypotension, change in diastolic blood pressure after an isometric exercise, and heart rate variability during expiration and inspiration) were evaluated. Binary logistic regression analysis was performed to find out the association of polypharmacy and total anticholinergic burden with cardiac autonomic neuropathy. A total of 305 patients (age, 68.9 ± 3.4; 65.9% male) were included. Of these patients, 81 (26.6%) were on polypharmacy. Out of these 81 patients, 42 patients were on ninety-eight potential inappropriate medications. The anticholinergic burden and the proportion of patients with cardiac autonomic neuropathy were significantly higher among patients who were on polypharmacy than those who were not (8.1 ± 2.3 vs. 2.3 ± 0.9; p = 0.03 and 56.8% vs. 44.6%; p = 0.01). The presence of polypharmacy and a total anticholinergic burden of > 3 was significantly associated with cardiac autonomic neuropathy (aOR, 2.66; 95% CI, 0.91–3.98 and aOR, 2.51; 95% CI, 0.99–3.52, respectively). Thus, polypharmacy was significantly associated with cardiac autonomic neuropathy among community-dwelling elderly patients. MDPI 2022-11-29 /pmc/articles/PMC9778147/ /pubmed/36547272 http://dx.doi.org/10.3390/geriatrics7060136 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Samajdar, Shambo Samrat Das, Saibal Sarkar, Sougata Mukherjee, Shatavisa Pathak, Ashish Stålsby Lundborg, Cecilia Saha, Indranil Tripathi, Santanu Kumar Pal, Jyotirmoy Chatterjee, Nandini Joshi, Shashank R Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study |
title | Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study |
title_full | Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study |
title_fullStr | Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study |
title_full_unstemmed | Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study |
title_short | Association between Polypharmacy and Cardiovascular Autonomic Function among Elderly Patients in an Urban Municipality Area of Kolkata, India: A Record-Based Cross-Sectional Study |
title_sort | association between polypharmacy and cardiovascular autonomic function among elderly patients in an urban municipality area of kolkata, india: a record-based cross-sectional study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778147/ https://www.ncbi.nlm.nih.gov/pubmed/36547272 http://dx.doi.org/10.3390/geriatrics7060136 |
work_keys_str_mv | AT samajdarshambosamrat associationbetweenpolypharmacyandcardiovascularautonomicfunctionamongelderlypatientsinanurbanmunicipalityareaofkolkataindiaarecordbasedcrosssectionalstudy AT dassaibal associationbetweenpolypharmacyandcardiovascularautonomicfunctionamongelderlypatientsinanurbanmunicipalityareaofkolkataindiaarecordbasedcrosssectionalstudy AT sarkarsougata associationbetweenpolypharmacyandcardiovascularautonomicfunctionamongelderlypatientsinanurbanmunicipalityareaofkolkataindiaarecordbasedcrosssectionalstudy AT mukherjeeshatavisa associationbetweenpolypharmacyandcardiovascularautonomicfunctionamongelderlypatientsinanurbanmunicipalityareaofkolkataindiaarecordbasedcrosssectionalstudy AT pathakashish associationbetweenpolypharmacyandcardiovascularautonomicfunctionamongelderlypatientsinanurbanmunicipalityareaofkolkataindiaarecordbasedcrosssectionalstudy AT stalsbylundborgcecilia associationbetweenpolypharmacyandcardiovascularautonomicfunctionamongelderlypatientsinanurbanmunicipalityareaofkolkataindiaarecordbasedcrosssectionalstudy AT sahaindranil associationbetweenpolypharmacyandcardiovascularautonomicfunctionamongelderlypatientsinanurbanmunicipalityareaofkolkataindiaarecordbasedcrosssectionalstudy AT tripathisantanukumar associationbetweenpolypharmacyandcardiovascularautonomicfunctionamongelderlypatientsinanurbanmunicipalityareaofkolkataindiaarecordbasedcrosssectionalstudy AT paljyotirmoy associationbetweenpolypharmacyandcardiovascularautonomicfunctionamongelderlypatientsinanurbanmunicipalityareaofkolkataindiaarecordbasedcrosssectionalstudy AT chatterjeenandini associationbetweenpolypharmacyandcardiovascularautonomicfunctionamongelderlypatientsinanurbanmunicipalityareaofkolkataindiaarecordbasedcrosssectionalstudy AT joshishashankr associationbetweenpolypharmacyandcardiovascularautonomicfunctionamongelderlypatientsinanurbanmunicipalityareaofkolkataindiaarecordbasedcrosssectionalstudy |