Xerogels Morphology Details by Multifractal Analysis and Scanning Electron Microscopy Images Evaluations of 5-Fluorouracil Release from Chitosan-Based Matrix

Four medicament delivery formulations based on 5-fluorouracil in a chitosan substantial matrix were realized in situ via 3,7-dimethyl-2,6-octadienal element hydrogelation. Representative samples of the final realized compounds were investigated from an analytic, constitutional, and morphological vie...

Descripción completa

Detalles Bibliográficos
Autores principales: Paun, Maria-Alexandra, Nichita, Mihai-Virgil, Paun, Vladimir-Alexandru, Paun, Viorel-Puiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778206/
https://www.ncbi.nlm.nih.gov/pubmed/36547344
http://dx.doi.org/10.3390/gels8120820
_version_ 1784856300697419776
author Paun, Maria-Alexandra
Nichita, Mihai-Virgil
Paun, Vladimir-Alexandru
Paun, Viorel-Puiu
author_facet Paun, Maria-Alexandra
Nichita, Mihai-Virgil
Paun, Vladimir-Alexandru
Paun, Viorel-Puiu
author_sort Paun, Maria-Alexandra
collection PubMed
description Four medicament delivery formulations based on 5-fluorouracil in a chitosan substantial matrix were realized in situ via 3,7-dimethyl-2,6-octadienal element hydrogelation. Representative samples of the final realized compounds were investigated from an analytic, constitutional, and morphological viewpoint via Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The SEM images of the formulations were investigated in concordance with fractal analysis, and the fractal dimensions and lacunarity were computed. The developed mathematical multifractal model is necessarily confirmed by the experimental measurements corresponding to the 5-fluorouracil release outside the chitosan-formed matrix.
format Online
Article
Text
id pubmed-9778206
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97782062022-12-23 Xerogels Morphology Details by Multifractal Analysis and Scanning Electron Microscopy Images Evaluations of 5-Fluorouracil Release from Chitosan-Based Matrix Paun, Maria-Alexandra Nichita, Mihai-Virgil Paun, Vladimir-Alexandru Paun, Viorel-Puiu Gels Article Four medicament delivery formulations based on 5-fluorouracil in a chitosan substantial matrix were realized in situ via 3,7-dimethyl-2,6-octadienal element hydrogelation. Representative samples of the final realized compounds were investigated from an analytic, constitutional, and morphological viewpoint via Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The SEM images of the formulations were investigated in concordance with fractal analysis, and the fractal dimensions and lacunarity were computed. The developed mathematical multifractal model is necessarily confirmed by the experimental measurements corresponding to the 5-fluorouracil release outside the chitosan-formed matrix. MDPI 2022-12-12 /pmc/articles/PMC9778206/ /pubmed/36547344 http://dx.doi.org/10.3390/gels8120820 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Paun, Maria-Alexandra
Nichita, Mihai-Virgil
Paun, Vladimir-Alexandru
Paun, Viorel-Puiu
Xerogels Morphology Details by Multifractal Analysis and Scanning Electron Microscopy Images Evaluations of 5-Fluorouracil Release from Chitosan-Based Matrix
title Xerogels Morphology Details by Multifractal Analysis and Scanning Electron Microscopy Images Evaluations of 5-Fluorouracil Release from Chitosan-Based Matrix
title_full Xerogels Morphology Details by Multifractal Analysis and Scanning Electron Microscopy Images Evaluations of 5-Fluorouracil Release from Chitosan-Based Matrix
title_fullStr Xerogels Morphology Details by Multifractal Analysis and Scanning Electron Microscopy Images Evaluations of 5-Fluorouracil Release from Chitosan-Based Matrix
title_full_unstemmed Xerogels Morphology Details by Multifractal Analysis and Scanning Electron Microscopy Images Evaluations of 5-Fluorouracil Release from Chitosan-Based Matrix
title_short Xerogels Morphology Details by Multifractal Analysis and Scanning Electron Microscopy Images Evaluations of 5-Fluorouracil Release from Chitosan-Based Matrix
title_sort xerogels morphology details by multifractal analysis and scanning electron microscopy images evaluations of 5-fluorouracil release from chitosan-based matrix
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778206/
https://www.ncbi.nlm.nih.gov/pubmed/36547344
http://dx.doi.org/10.3390/gels8120820
work_keys_str_mv AT paunmariaalexandra xerogelsmorphologydetailsbymultifractalanalysisandscanningelectronmicroscopyimagesevaluationsof5fluorouracilreleasefromchitosanbasedmatrix
AT nichitamihaivirgil xerogelsmorphologydetailsbymultifractalanalysisandscanningelectronmicroscopyimagesevaluationsof5fluorouracilreleasefromchitosanbasedmatrix
AT paunvladimiralexandru xerogelsmorphologydetailsbymultifractalanalysisandscanningelectronmicroscopyimagesevaluationsof5fluorouracilreleasefromchitosanbasedmatrix
AT paunviorelpuiu xerogelsmorphologydetailsbymultifractalanalysisandscanningelectronmicroscopyimagesevaluationsof5fluorouracilreleasefromchitosanbasedmatrix

Ejemplares similares