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Comorbidity and Cancer Disease Rates among Those at High-Risk for Alzheimer’s Disease: A Population Database Analysis

(1) Importance: Alzheimer’s disease (AD) is complex and only partially understood. Analyzing the relationship between other more treatable or preventable diseases and AD may help in the prevention and the eventual development of treatments for AD. Risk estimation in a high-risk population, rather th...

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Autores principales: Valentine, David, Teerlink, Craig C., Farnham, James M., Rowe, Kerry, Kaddas, Heydon, Tschanz, JoAnn, Kauwe, John S. K., Cannon-Albright, Lisa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778263/
https://www.ncbi.nlm.nih.gov/pubmed/36554301
http://dx.doi.org/10.3390/ijerph192416419
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author Valentine, David
Teerlink, Craig C.
Farnham, James M.
Rowe, Kerry
Kaddas, Heydon
Tschanz, JoAnn
Kauwe, John S. K.
Cannon-Albright, Lisa A.
author_facet Valentine, David
Teerlink, Craig C.
Farnham, James M.
Rowe, Kerry
Kaddas, Heydon
Tschanz, JoAnn
Kauwe, John S. K.
Cannon-Albright, Lisa A.
author_sort Valentine, David
collection PubMed
description (1) Importance: Alzheimer’s disease (AD) is complex and only partially understood. Analyzing the relationship between other more treatable or preventable diseases and AD may help in the prevention and the eventual development of treatments for AD. Risk estimation in a high-risk population, rather than a population already affected with AD, may reduce some bias in risk estimates. (2) Objective: To examine the rates of various comorbidities and cancers in individuals at high-risk for AD, but without a clinical diagnosis, relative to individuals from the same population with normal AD risk. (3) Design, Setting, and Participants: We conducted a study using data from the Utah Population Database (UPDB). The UPDB contains linked data from the Utah Cancer Registry, Utah death certificates, the Intermountain Health patient population, and the University of Utah Health patient population. Subjects were selected based on the availability of ancestral data, linked health information, and self-reported biometrics. (4) Results: In total, 75,877 participants who were estimated to be at high risk for AD based on family history, but who did not have an active AD diagnosis, were analyzed. A lower incidence of diabetes (RR = 0.95, 95% CI [0.92,0.97], p < 0.001), hypertension (RR = 0.97, 95% CI [0.95,0.99], p < 0.001), and heart disease (RR = 0.95, 95% CI [0.93,0.98], p < 0.001) was found. There was no difference in rates of cerebrovascular disease or other forms of dementia. Of the 15 types of cancer analyzed: breast (RR = 1.23, 95% CI [1.16, 1.30], p < 0.001); colorectal (RR = 1.30, 95% CI [1.21, 1.39], p < 0.001); kidney (RR = 1.49, 95% CI (1.29, 1.72), p < 0.001); lung (RR = 1.25, 95% CI [1.13, 1.37], p < 0.001); non-Hodgkin’s Lymphoma (RR = 1.29, 95% CI [1.15, 1.44], p < 0.001); pancreas (RR = 1.34, 95% CI [1.16, 1.55], p < 0.001); stomach (RR = 1.59, 95% CI [1.36, 1.86], p < 0.001); and bladder (RR = 1.40, 95% CI [1.25, 1.56], p < 0.001), cancers were observed in significant excess among individuals at high-risk for AD after correction for multiple testing. (5) Conclusions and Relevance: Since age is the greatest risk factor for the development of AD, individuals who reach more advanced ages are at increased risk of developing AD. Consistent with this, people with fewer comorbidities earlier in life are more likely to reach an age where AD becomes a larger risk. Our findings show that individuals at high risk for AD have a decreased incidence of various other diseases. This is further supported by our finding that our high-risk group was also found to have an increased incidence of various cancers, which also increase in risk with age. There is the possibility that a more meaningful or etiological relationship exists among these various comorbidities. Further research into the etiological relationship between AD and these comorbidities may elucidate these possible interactions.
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spelling pubmed-97782632022-12-23 Comorbidity and Cancer Disease Rates among Those at High-Risk for Alzheimer’s Disease: A Population Database Analysis Valentine, David Teerlink, Craig C. Farnham, James M. Rowe, Kerry Kaddas, Heydon Tschanz, JoAnn Kauwe, John S. K. Cannon-Albright, Lisa A. Int J Environ Res Public Health Article (1) Importance: Alzheimer’s disease (AD) is complex and only partially understood. Analyzing the relationship between other more treatable or preventable diseases and AD may help in the prevention and the eventual development of treatments for AD. Risk estimation in a high-risk population, rather than a population already affected with AD, may reduce some bias in risk estimates. (2) Objective: To examine the rates of various comorbidities and cancers in individuals at high-risk for AD, but without a clinical diagnosis, relative to individuals from the same population with normal AD risk. (3) Design, Setting, and Participants: We conducted a study using data from the Utah Population Database (UPDB). The UPDB contains linked data from the Utah Cancer Registry, Utah death certificates, the Intermountain Health patient population, and the University of Utah Health patient population. Subjects were selected based on the availability of ancestral data, linked health information, and self-reported biometrics. (4) Results: In total, 75,877 participants who were estimated to be at high risk for AD based on family history, but who did not have an active AD diagnosis, were analyzed. A lower incidence of diabetes (RR = 0.95, 95% CI [0.92,0.97], p < 0.001), hypertension (RR = 0.97, 95% CI [0.95,0.99], p < 0.001), and heart disease (RR = 0.95, 95% CI [0.93,0.98], p < 0.001) was found. There was no difference in rates of cerebrovascular disease or other forms of dementia. Of the 15 types of cancer analyzed: breast (RR = 1.23, 95% CI [1.16, 1.30], p < 0.001); colorectal (RR = 1.30, 95% CI [1.21, 1.39], p < 0.001); kidney (RR = 1.49, 95% CI (1.29, 1.72), p < 0.001); lung (RR = 1.25, 95% CI [1.13, 1.37], p < 0.001); non-Hodgkin’s Lymphoma (RR = 1.29, 95% CI [1.15, 1.44], p < 0.001); pancreas (RR = 1.34, 95% CI [1.16, 1.55], p < 0.001); stomach (RR = 1.59, 95% CI [1.36, 1.86], p < 0.001); and bladder (RR = 1.40, 95% CI [1.25, 1.56], p < 0.001), cancers were observed in significant excess among individuals at high-risk for AD after correction for multiple testing. (5) Conclusions and Relevance: Since age is the greatest risk factor for the development of AD, individuals who reach more advanced ages are at increased risk of developing AD. Consistent with this, people with fewer comorbidities earlier in life are more likely to reach an age where AD becomes a larger risk. Our findings show that individuals at high risk for AD have a decreased incidence of various other diseases. This is further supported by our finding that our high-risk group was also found to have an increased incidence of various cancers, which also increase in risk with age. There is the possibility that a more meaningful or etiological relationship exists among these various comorbidities. Further research into the etiological relationship between AD and these comorbidities may elucidate these possible interactions. MDPI 2022-12-07 /pmc/articles/PMC9778263/ /pubmed/36554301 http://dx.doi.org/10.3390/ijerph192416419 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Valentine, David
Teerlink, Craig C.
Farnham, James M.
Rowe, Kerry
Kaddas, Heydon
Tschanz, JoAnn
Kauwe, John S. K.
Cannon-Albright, Lisa A.
Comorbidity and Cancer Disease Rates among Those at High-Risk for Alzheimer’s Disease: A Population Database Analysis
title Comorbidity and Cancer Disease Rates among Those at High-Risk for Alzheimer’s Disease: A Population Database Analysis
title_full Comorbidity and Cancer Disease Rates among Those at High-Risk for Alzheimer’s Disease: A Population Database Analysis
title_fullStr Comorbidity and Cancer Disease Rates among Those at High-Risk for Alzheimer’s Disease: A Population Database Analysis
title_full_unstemmed Comorbidity and Cancer Disease Rates among Those at High-Risk for Alzheimer’s Disease: A Population Database Analysis
title_short Comorbidity and Cancer Disease Rates among Those at High-Risk for Alzheimer’s Disease: A Population Database Analysis
title_sort comorbidity and cancer disease rates among those at high-risk for alzheimer’s disease: a population database analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778263/
https://www.ncbi.nlm.nih.gov/pubmed/36554301
http://dx.doi.org/10.3390/ijerph192416419
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