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Promoter-Adjacent DNA Hypermethylation Can Downmodulate Gene Expression: TBX15 in the Muscle Lineage

TBX15, which encodes a differentiation-related transcription factor, displays promoter-adjacent DNA hypermethylation in myoblasts and skeletal muscle (psoas) that is absent from non-expressing cells in other lineages. By whole-genome bisulfite sequencing (WGBS) and enzymatic methyl-seq (EM-seq), the...

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Detalles Bibliográficos
Autores principales:	Ehrlich, Kenneth C., Lacey, Michelle, Baribault, Carl, Sen, Sagnik, Esteve, Pierre Olivier, Pradhan, Sriharsa, Ehrlich, Melanie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778270/ https://www.ncbi.nlm.nih.gov/pubmed/36547252 http://dx.doi.org/10.3390/epigenomes6040043

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