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Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet

The present study examined the influence of inulin on fecal microbiota, cardiometabolic risk factors, eicosanoids, and oxidative stress in rats on a high-fat (HF) diet. Thirty-six male Wistar–Kyoto rats were divided into three dietary groups: standard diet, HF diet, and HF diet + Inulin diet. After...

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Autores principales: Miralles-Pérez, Bernat, Nogués, Maria Rosa, Sánchez-Martos, Vanessa, Fortuño-Mar, Àngels, Ramos-Romero, Sara, Torres, Josep L., Ponomarenko, Julia, Amézqueta, Susana, Zhang, Xiang, Romeu, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778385/
https://www.ncbi.nlm.nih.gov/pubmed/36553814
http://dx.doi.org/10.3390/foods11244072
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author Miralles-Pérez, Bernat
Nogués, Maria Rosa
Sánchez-Martos, Vanessa
Fortuño-Mar, Àngels
Ramos-Romero, Sara
Torres, Josep L.
Ponomarenko, Julia
Amézqueta, Susana
Zhang, Xiang
Romeu, Marta
author_facet Miralles-Pérez, Bernat
Nogués, Maria Rosa
Sánchez-Martos, Vanessa
Fortuño-Mar, Àngels
Ramos-Romero, Sara
Torres, Josep L.
Ponomarenko, Julia
Amézqueta, Susana
Zhang, Xiang
Romeu, Marta
author_sort Miralles-Pérez, Bernat
collection PubMed
description The present study examined the influence of inulin on fecal microbiota, cardiometabolic risk factors, eicosanoids, and oxidative stress in rats on a high-fat (HF) diet. Thirty-six male Wistar–Kyoto rats were divided into three dietary groups: standard diet, HF diet, and HF diet + Inulin diet. After 10 weeks, the HF + Inulin diet promoted high dominance of a few bacterial genera including Blautia and Olsenella in feces while reducing richness, diversity, and rarity compared to the HF diet. These changes in fecal microbiota were accompanied by an increased amount of propionic acid in feces. The HF + Inulin diet decreased cardiometabolic risk factors, decreased the amount of the eicosanoids 11(12)-EET and 15-HETrE in the liver, and decreased oxidative stress in blood compared to the HF diet. In conclusion, increasing consumption of inulin may be a useful nutritional strategy to protect against the onset of obesity and its associated metabolic abnormalities by means of modulation of gut microbiota.
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spelling pubmed-97783852022-12-23 Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet Miralles-Pérez, Bernat Nogués, Maria Rosa Sánchez-Martos, Vanessa Fortuño-Mar, Àngels Ramos-Romero, Sara Torres, Josep L. Ponomarenko, Julia Amézqueta, Susana Zhang, Xiang Romeu, Marta Foods Article The present study examined the influence of inulin on fecal microbiota, cardiometabolic risk factors, eicosanoids, and oxidative stress in rats on a high-fat (HF) diet. Thirty-six male Wistar–Kyoto rats were divided into three dietary groups: standard diet, HF diet, and HF diet + Inulin diet. After 10 weeks, the HF + Inulin diet promoted high dominance of a few bacterial genera including Blautia and Olsenella in feces while reducing richness, diversity, and rarity compared to the HF diet. These changes in fecal microbiota were accompanied by an increased amount of propionic acid in feces. The HF + Inulin diet decreased cardiometabolic risk factors, decreased the amount of the eicosanoids 11(12)-EET and 15-HETrE in the liver, and decreased oxidative stress in blood compared to the HF diet. In conclusion, increasing consumption of inulin may be a useful nutritional strategy to protect against the onset of obesity and its associated metabolic abnormalities by means of modulation of gut microbiota. MDPI 2022-12-16 /pmc/articles/PMC9778385/ /pubmed/36553814 http://dx.doi.org/10.3390/foods11244072 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Miralles-Pérez, Bernat
Nogués, Maria Rosa
Sánchez-Martos, Vanessa
Fortuño-Mar, Àngels
Ramos-Romero, Sara
Torres, Josep L.
Ponomarenko, Julia
Amézqueta, Susana
Zhang, Xiang
Romeu, Marta
Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet
title Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet
title_full Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet
title_fullStr Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet
title_full_unstemmed Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet
title_short Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet
title_sort influence of dietary inulin on fecal microbiota, cardiometabolic risk factors, eicosanoids, and oxidative stress in rats fed a high-fat diet
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778385/
https://www.ncbi.nlm.nih.gov/pubmed/36553814
http://dx.doi.org/10.3390/foods11244072
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