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Genetic Variants and Protective Immunity against SARS-CoV-2

The novel coronavirus-19 (SARS-CoV-2), has infected numerous individuals worldwide, resulting in millions of fatalities. The pandemic spread with high mortality rates in multiple waves, leaving others with moderate to severe symptoms. Co-morbidity variables, including hypertension, diabetes, and imm...

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Autores principales: Rabaan, Ali A., Mutair, Abbas Al, Aljeldah, Mohammed, Shammari, Basim R. Al, Sulaiman, Tarek, Alshukairi, Abeer N., Alfaresi, Mubarak, Al-Jishi, Jumana M., Al Bati, Neda A., Al-Mozaini, Maha A., Bshabshe, Ali Al, Almatouq, Jenan A., Abuzaid, Abdulmonem A., Alfaraj, Amal H., Al-Adsani, Wasl, Alabdullah, Mohammed, Alwarthan, Sara, Alsalman, Fatimah, Alwashmi, Ameen S. S., Alhumaid, Saad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778397/
https://www.ncbi.nlm.nih.gov/pubmed/36553622
http://dx.doi.org/10.3390/genes13122355
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author Rabaan, Ali A.
Mutair, Abbas Al
Aljeldah, Mohammed
Shammari, Basim R. Al
Sulaiman, Tarek
Alshukairi, Abeer N.
Alfaresi, Mubarak
Al-Jishi, Jumana M.
Al Bati, Neda A.
Al-Mozaini, Maha A.
Bshabshe, Ali Al
Almatouq, Jenan A.
Abuzaid, Abdulmonem A.
Alfaraj, Amal H.
Al-Adsani, Wasl
Alabdullah, Mohammed
Alwarthan, Sara
Alsalman, Fatimah
Alwashmi, Ameen S. S.
Alhumaid, Saad
author_facet Rabaan, Ali A.
Mutair, Abbas Al
Aljeldah, Mohammed
Shammari, Basim R. Al
Sulaiman, Tarek
Alshukairi, Abeer N.
Alfaresi, Mubarak
Al-Jishi, Jumana M.
Al Bati, Neda A.
Al-Mozaini, Maha A.
Bshabshe, Ali Al
Almatouq, Jenan A.
Abuzaid, Abdulmonem A.
Alfaraj, Amal H.
Al-Adsani, Wasl
Alabdullah, Mohammed
Alwarthan, Sara
Alsalman, Fatimah
Alwashmi, Ameen S. S.
Alhumaid, Saad
author_sort Rabaan, Ali A.
collection PubMed
description The novel coronavirus-19 (SARS-CoV-2), has infected numerous individuals worldwide, resulting in millions of fatalities. The pandemic spread with high mortality rates in multiple waves, leaving others with moderate to severe symptoms. Co-morbidity variables, including hypertension, diabetes, and immunosuppression, have exacerbated the severity of COVID-19. In addition, numerous efforts have been made to comprehend the pathogenic and host variables that contribute to COVID-19 susceptibility and pathogenesis. One of these endeavours is understanding the host genetic factors predisposing an individual to COVID-19. Genome-Wide Association Studies (GWAS) have demonstrated the host predisposition factors in different populations. These factors are involved in the appropriate immune response, their imbalance influences susceptibility or resistance to viral infection. This review investigated the host genetic components implicated at the various stages of viral pathogenesis, including viral entry, pathophysiological alterations, and immunological responses. In addition, the recent and most updated genetic variations associated with multiple host factors affecting COVID-19 pathogenesis are described in the study.
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spelling pubmed-97783972022-12-23 Genetic Variants and Protective Immunity against SARS-CoV-2 Rabaan, Ali A. Mutair, Abbas Al Aljeldah, Mohammed Shammari, Basim R. Al Sulaiman, Tarek Alshukairi, Abeer N. Alfaresi, Mubarak Al-Jishi, Jumana M. Al Bati, Neda A. Al-Mozaini, Maha A. Bshabshe, Ali Al Almatouq, Jenan A. Abuzaid, Abdulmonem A. Alfaraj, Amal H. Al-Adsani, Wasl Alabdullah, Mohammed Alwarthan, Sara Alsalman, Fatimah Alwashmi, Ameen S. S. Alhumaid, Saad Genes (Basel) Review The novel coronavirus-19 (SARS-CoV-2), has infected numerous individuals worldwide, resulting in millions of fatalities. The pandemic spread with high mortality rates in multiple waves, leaving others with moderate to severe symptoms. Co-morbidity variables, including hypertension, diabetes, and immunosuppression, have exacerbated the severity of COVID-19. In addition, numerous efforts have been made to comprehend the pathogenic and host variables that contribute to COVID-19 susceptibility and pathogenesis. One of these endeavours is understanding the host genetic factors predisposing an individual to COVID-19. Genome-Wide Association Studies (GWAS) have demonstrated the host predisposition factors in different populations. These factors are involved in the appropriate immune response, their imbalance influences susceptibility or resistance to viral infection. This review investigated the host genetic components implicated at the various stages of viral pathogenesis, including viral entry, pathophysiological alterations, and immunological responses. In addition, the recent and most updated genetic variations associated with multiple host factors affecting COVID-19 pathogenesis are described in the study. MDPI 2022-12-13 /pmc/articles/PMC9778397/ /pubmed/36553622 http://dx.doi.org/10.3390/genes13122355 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rabaan, Ali A.
Mutair, Abbas Al
Aljeldah, Mohammed
Shammari, Basim R. Al
Sulaiman, Tarek
Alshukairi, Abeer N.
Alfaresi, Mubarak
Al-Jishi, Jumana M.
Al Bati, Neda A.
Al-Mozaini, Maha A.
Bshabshe, Ali Al
Almatouq, Jenan A.
Abuzaid, Abdulmonem A.
Alfaraj, Amal H.
Al-Adsani, Wasl
Alabdullah, Mohammed
Alwarthan, Sara
Alsalman, Fatimah
Alwashmi, Ameen S. S.
Alhumaid, Saad
Genetic Variants and Protective Immunity against SARS-CoV-2
title Genetic Variants and Protective Immunity against SARS-CoV-2
title_full Genetic Variants and Protective Immunity against SARS-CoV-2
title_fullStr Genetic Variants and Protective Immunity against SARS-CoV-2
title_full_unstemmed Genetic Variants and Protective Immunity against SARS-CoV-2
title_short Genetic Variants and Protective Immunity against SARS-CoV-2
title_sort genetic variants and protective immunity against sars-cov-2
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778397/
https://www.ncbi.nlm.nih.gov/pubmed/36553622
http://dx.doi.org/10.3390/genes13122355
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