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Ancestral risk modification for multiple sclerosis susceptibility detected across the Major Histocompatibility Complex in a multi-ethnic population

The Major Histocompatibility Complex (MHC) makes the largest genetic contribution to multiple sclerosis (MS) susceptibility, with 32 independent effects across the region explaining 20% of the heritability in European populations. Variation is high across populations with allele frequency difference...

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Detalles Bibliográficos
Autores principales:	Beecham, Ashley H., Amezcua, Lilyana, Chinea, Angel, Manrique, Clara P., Gomez, Lissette, Martinez, Andrea, Beecham, Gary W., Patsopoulos, Nikolaos A., Chitnis, Tanuja, Weiner, Howard L., De Jager, Philip L., Burchard, Esteban G., Lund, Brett T., Fitzgerald, Kathryn C., Calabresi, Peter A., Delgado, Silvia R., Oksenberg, Jorge R., McCauley, Jacob L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778564/ https://www.ncbi.nlm.nih.gov/pubmed/36548255 http://dx.doi.org/10.1371/journal.pone.0279132

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