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The Analysis of Blood Inflammation Markers as Prognostic Factors in Parkinson’s Disease

Parkinson’s disease is a chronic, progressive, and neurodegenerative disease, and yet with an imprecise etiopathogenesis. Although neuroinflammation was initially thought to be a secondary condition, it is now believed that microglia-induced inflammation could also contribute to the degeneration of...

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Autores principales: Stanca, Iulia-Diana, Criciotoiu, Oana, Neamtu, Simona-Daniela, Vasile, Ramona-Constantina, Berceanu-Bora, Nicoleta-Madalina, Minca, Teodora-Nicoleta, Pirici, Ionica, Rosu, Gabriela-Camelia, Bondari, Simona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778576/
https://www.ncbi.nlm.nih.gov/pubmed/36554101
http://dx.doi.org/10.3390/healthcare10122578
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author Stanca, Iulia-Diana
Criciotoiu, Oana
Neamtu, Simona-Daniela
Vasile, Ramona-Constantina
Berceanu-Bora, Nicoleta-Madalina
Minca, Teodora-Nicoleta
Pirici, Ionica
Rosu, Gabriela-Camelia
Bondari, Simona
author_facet Stanca, Iulia-Diana
Criciotoiu, Oana
Neamtu, Simona-Daniela
Vasile, Ramona-Constantina
Berceanu-Bora, Nicoleta-Madalina
Minca, Teodora-Nicoleta
Pirici, Ionica
Rosu, Gabriela-Camelia
Bondari, Simona
author_sort Stanca, Iulia-Diana
collection PubMed
description Parkinson’s disease is a chronic, progressive, and neurodegenerative disease, and yet with an imprecise etiopathogenesis. Although neuroinflammation was initially thought to be a secondary condition, it is now believed that microglia-induced inflammation could also contribute to the degeneration of the nigrostriatal pathway. Here, we aimed to establish the feasibility of basic inflammatory biomarkers as prognostic factors in PD. The study was based on retrospective analyses of blood samples taken from patients diagnosed with PD, as well as from healthy subjects. Complete medical records, total leukocyte count with subpopulations, and erythrocyte sedimentation rate (ESR) were analyzed. We calculated the serum neutrophils-to-lymphocytes ratio (NLR) and platelet-to lymphocytes ratio (PLR), and also compared the laboratory data between the PD group and the control group. Only PLR and NLR showed statistically significant differences (p < 0.001 and 0.04, respectively). In our study, ESR did not show statistically significant correlations with motor score or with disability. In our research, ESR was correlated with the disease duration (p = 0.04), and PLR showed a significant correlation with disease stage (p = 0.027) and disease duration (p = 0.001), but not with motor state. These biomarkers could prove to be effective tools for a primary evaluation of inflammation in PD, but further tests are required to properly investigate the neuroinflammatory status of these patients.
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spelling pubmed-97785762022-12-23 The Analysis of Blood Inflammation Markers as Prognostic Factors in Parkinson’s Disease Stanca, Iulia-Diana Criciotoiu, Oana Neamtu, Simona-Daniela Vasile, Ramona-Constantina Berceanu-Bora, Nicoleta-Madalina Minca, Teodora-Nicoleta Pirici, Ionica Rosu, Gabriela-Camelia Bondari, Simona Healthcare (Basel) Article Parkinson’s disease is a chronic, progressive, and neurodegenerative disease, and yet with an imprecise etiopathogenesis. Although neuroinflammation was initially thought to be a secondary condition, it is now believed that microglia-induced inflammation could also contribute to the degeneration of the nigrostriatal pathway. Here, we aimed to establish the feasibility of basic inflammatory biomarkers as prognostic factors in PD. The study was based on retrospective analyses of blood samples taken from patients diagnosed with PD, as well as from healthy subjects. Complete medical records, total leukocyte count with subpopulations, and erythrocyte sedimentation rate (ESR) were analyzed. We calculated the serum neutrophils-to-lymphocytes ratio (NLR) and platelet-to lymphocytes ratio (PLR), and also compared the laboratory data between the PD group and the control group. Only PLR and NLR showed statistically significant differences (p < 0.001 and 0.04, respectively). In our study, ESR did not show statistically significant correlations with motor score or with disability. In our research, ESR was correlated with the disease duration (p = 0.04), and PLR showed a significant correlation with disease stage (p = 0.027) and disease duration (p = 0.001), but not with motor state. These biomarkers could prove to be effective tools for a primary evaluation of inflammation in PD, but further tests are required to properly investigate the neuroinflammatory status of these patients. MDPI 2022-12-19 /pmc/articles/PMC9778576/ /pubmed/36554101 http://dx.doi.org/10.3390/healthcare10122578 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stanca, Iulia-Diana
Criciotoiu, Oana
Neamtu, Simona-Daniela
Vasile, Ramona-Constantina
Berceanu-Bora, Nicoleta-Madalina
Minca, Teodora-Nicoleta
Pirici, Ionica
Rosu, Gabriela-Camelia
Bondari, Simona
The Analysis of Blood Inflammation Markers as Prognostic Factors in Parkinson’s Disease
title The Analysis of Blood Inflammation Markers as Prognostic Factors in Parkinson’s Disease
title_full The Analysis of Blood Inflammation Markers as Prognostic Factors in Parkinson’s Disease
title_fullStr The Analysis of Blood Inflammation Markers as Prognostic Factors in Parkinson’s Disease
title_full_unstemmed The Analysis of Blood Inflammation Markers as Prognostic Factors in Parkinson’s Disease
title_short The Analysis of Blood Inflammation Markers as Prognostic Factors in Parkinson’s Disease
title_sort analysis of blood inflammation markers as prognostic factors in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778576/
https://www.ncbi.nlm.nih.gov/pubmed/36554101
http://dx.doi.org/10.3390/healthcare10122578
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