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Human Genetic Research in Wallacea and Sahul: Recent Findings and Future Prospects

Genomic sequence data from worldwide human populations have provided a range of novel insights into our shared ancestry and the historical migrations that have shaped our global genetic diversity. However, a comprehensive understanding of these fundamental questions has been impeded by the lack of i...

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Autores principales: Taufik, Leonard, Teixeira, João C., Llamas, Bastien, Sudoyo, Herawati, Tobler, Raymond, Purnomo, Gludhug A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778601/
https://www.ncbi.nlm.nih.gov/pubmed/36553640
http://dx.doi.org/10.3390/genes13122373
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author Taufik, Leonard
Teixeira, João C.
Llamas, Bastien
Sudoyo, Herawati
Tobler, Raymond
Purnomo, Gludhug A.
author_facet Taufik, Leonard
Teixeira, João C.
Llamas, Bastien
Sudoyo, Herawati
Tobler, Raymond
Purnomo, Gludhug A.
author_sort Taufik, Leonard
collection PubMed
description Genomic sequence data from worldwide human populations have provided a range of novel insights into our shared ancestry and the historical migrations that have shaped our global genetic diversity. However, a comprehensive understanding of these fundamental questions has been impeded by the lack of inclusion of many Indigenous populations in genomic surveys, including those from the Wallacean archipelago (which comprises islands of present-day Indonesia located east and west of Wallace’s and Lydekker’s Lines, respectively) and the former continent of Sahul (which once combined New Guinea and Australia during lower sea levels in the Pleistocene). Notably, these regions have been important areas of human evolution throughout the Late Pleistocene, as documented by diverse fossil and archaeological records which attest to the regional presence of multiple hominin species prior to the arrival of anatomically modern human (AMH) migrants. In this review, we collate and discuss key findings from the past decade of population genetic and phylogeographic literature focussed on the hominin history in Wallacea and Sahul. Specifically, we examine the evidence for the timing and direction of the ancient AMH migratory movements and subsequent hominin mixing events, emphasising several novel but consistent results that have important implications for addressing these questions. Finally, we suggest potentially lucrative directions for future genetic research in this key region of human evolution.
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spelling pubmed-97786012022-12-23 Human Genetic Research in Wallacea and Sahul: Recent Findings and Future Prospects Taufik, Leonard Teixeira, João C. Llamas, Bastien Sudoyo, Herawati Tobler, Raymond Purnomo, Gludhug A. Genes (Basel) Systematic Review Genomic sequence data from worldwide human populations have provided a range of novel insights into our shared ancestry and the historical migrations that have shaped our global genetic diversity. However, a comprehensive understanding of these fundamental questions has been impeded by the lack of inclusion of many Indigenous populations in genomic surveys, including those from the Wallacean archipelago (which comprises islands of present-day Indonesia located east and west of Wallace’s and Lydekker’s Lines, respectively) and the former continent of Sahul (which once combined New Guinea and Australia during lower sea levels in the Pleistocene). Notably, these regions have been important areas of human evolution throughout the Late Pleistocene, as documented by diverse fossil and archaeological records which attest to the regional presence of multiple hominin species prior to the arrival of anatomically modern human (AMH) migrants. In this review, we collate and discuss key findings from the past decade of population genetic and phylogeographic literature focussed on the hominin history in Wallacea and Sahul. Specifically, we examine the evidence for the timing and direction of the ancient AMH migratory movements and subsequent hominin mixing events, emphasising several novel but consistent results that have important implications for addressing these questions. Finally, we suggest potentially lucrative directions for future genetic research in this key region of human evolution. MDPI 2022-12-16 /pmc/articles/PMC9778601/ /pubmed/36553640 http://dx.doi.org/10.3390/genes13122373 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Taufik, Leonard
Teixeira, João C.
Llamas, Bastien
Sudoyo, Herawati
Tobler, Raymond
Purnomo, Gludhug A.
Human Genetic Research in Wallacea and Sahul: Recent Findings and Future Prospects
title Human Genetic Research in Wallacea and Sahul: Recent Findings and Future Prospects
title_full Human Genetic Research in Wallacea and Sahul: Recent Findings and Future Prospects
title_fullStr Human Genetic Research in Wallacea and Sahul: Recent Findings and Future Prospects
title_full_unstemmed Human Genetic Research in Wallacea and Sahul: Recent Findings and Future Prospects
title_short Human Genetic Research in Wallacea and Sahul: Recent Findings and Future Prospects
title_sort human genetic research in wallacea and sahul: recent findings and future prospects
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778601/
https://www.ncbi.nlm.nih.gov/pubmed/36553640
http://dx.doi.org/10.3390/genes13122373
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