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Exposure to Inorganic Arsenic in Rice in Brazil: A Human Health Risk Assessment

In certain populations, rice is the main source of exposure to inorganic arsenic (iAs), which is associated with cancer and non-cancer effects. Although rice is a staple food in Brazil, there have been few studies about the health risks for the Brazilian population. The objective of this study was t...

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Autores principales: Toledo, Michele C., Lee, Janice S., Batista, Bruno L., Olympio, Kelly P. K., Nardocci, Adelaide C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778750/
https://www.ncbi.nlm.nih.gov/pubmed/36554339
http://dx.doi.org/10.3390/ijerph192416460
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author Toledo, Michele C.
Lee, Janice S.
Batista, Bruno L.
Olympio, Kelly P. K.
Nardocci, Adelaide C.
author_facet Toledo, Michele C.
Lee, Janice S.
Batista, Bruno L.
Olympio, Kelly P. K.
Nardocci, Adelaide C.
author_sort Toledo, Michele C.
collection PubMed
description In certain populations, rice is the main source of exposure to inorganic arsenic (iAs), which is associated with cancer and non-cancer effects. Although rice is a staple food in Brazil, there have been few studies about the health risks for the Brazilian population. The objective of this study was to assess the risks of exposure to iAs from white rice and brown rice in Brazil, in terms of the carcinogenic and non-carcinogenic effects, and to propose measures to mitigate those risks. The incremental lifetime cancer risk (ILCR) and hazard quotient (HQ) were calculated in a probabilistic framework. The mean ILCR was 1.5 × 10(−4) for white rice and 6.0 × 10(−6) for brown rice. The HQ for white and brown rice was under 1. The ILCR for white and brown rice was high, even though the iAs concentration in rice is below the maximum contaminant level. The risk for brown rice consumption was lower, which was not expected. Various mitigation measures discussed in this report are estimated to reduce the risk from rice consumption by 5–67%. With the support of public policies, measures to reduce these risks for the Brazilian population would have a positive impact on public health.
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spelling pubmed-97787502022-12-23 Exposure to Inorganic Arsenic in Rice in Brazil: A Human Health Risk Assessment Toledo, Michele C. Lee, Janice S. Batista, Bruno L. Olympio, Kelly P. K. Nardocci, Adelaide C. Int J Environ Res Public Health Article In certain populations, rice is the main source of exposure to inorganic arsenic (iAs), which is associated with cancer and non-cancer effects. Although rice is a staple food in Brazil, there have been few studies about the health risks for the Brazilian population. The objective of this study was to assess the risks of exposure to iAs from white rice and brown rice in Brazil, in terms of the carcinogenic and non-carcinogenic effects, and to propose measures to mitigate those risks. The incremental lifetime cancer risk (ILCR) and hazard quotient (HQ) were calculated in a probabilistic framework. The mean ILCR was 1.5 × 10(−4) for white rice and 6.0 × 10(−6) for brown rice. The HQ for white and brown rice was under 1. The ILCR for white and brown rice was high, even though the iAs concentration in rice is below the maximum contaminant level. The risk for brown rice consumption was lower, which was not expected. Various mitigation measures discussed in this report are estimated to reduce the risk from rice consumption by 5–67%. With the support of public policies, measures to reduce these risks for the Brazilian population would have a positive impact on public health. MDPI 2022-12-08 /pmc/articles/PMC9778750/ /pubmed/36554339 http://dx.doi.org/10.3390/ijerph192416460 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Toledo, Michele C.
Lee, Janice S.
Batista, Bruno L.
Olympio, Kelly P. K.
Nardocci, Adelaide C.
Exposure to Inorganic Arsenic in Rice in Brazil: A Human Health Risk Assessment
title Exposure to Inorganic Arsenic in Rice in Brazil: A Human Health Risk Assessment
title_full Exposure to Inorganic Arsenic in Rice in Brazil: A Human Health Risk Assessment
title_fullStr Exposure to Inorganic Arsenic in Rice in Brazil: A Human Health Risk Assessment
title_full_unstemmed Exposure to Inorganic Arsenic in Rice in Brazil: A Human Health Risk Assessment
title_short Exposure to Inorganic Arsenic in Rice in Brazil: A Human Health Risk Assessment
title_sort exposure to inorganic arsenic in rice in brazil: a human health risk assessment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778750/
https://www.ncbi.nlm.nih.gov/pubmed/36554339
http://dx.doi.org/10.3390/ijerph192416460
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