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Influence of Single Deuterium Replacement on Frequency of Hydrogen Bond Dissociation in IFNA17 under the Highest Critical Energy Range

The effect of single substitutions of protium for deuterium in hydrogen bonds between pairs of nitrogenous bases on the open states occurrence probability at high critical breaking energies of these bonds has been studied. The study was carried out using numerical methods based on the angular mathem...

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Autores principales: Basov, Alexander, Drobotenko, Mikhail, Svidlov, Alexander, Bezhenar, Maria, Gerasimenko, Eugeny, Moiseev, Arkadii, Malyshko, Vadim, Dorohova, Anna, Drozdov, Andrey, Baryshev, Mikhail, Dzhimak, Stepan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778762/
https://www.ncbi.nlm.nih.gov/pubmed/36555136
http://dx.doi.org/10.3390/ijms232415487
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author Basov, Alexander
Drobotenko, Mikhail
Svidlov, Alexander
Bezhenar, Maria
Gerasimenko, Eugeny
Moiseev, Arkadii
Malyshko, Vadim
Dorohova, Anna
Drozdov, Andrey
Baryshev, Mikhail
Dzhimak, Stepan
author_facet Basov, Alexander
Drobotenko, Mikhail
Svidlov, Alexander
Bezhenar, Maria
Gerasimenko, Eugeny
Moiseev, Arkadii
Malyshko, Vadim
Dorohova, Anna
Drozdov, Andrey
Baryshev, Mikhail
Dzhimak, Stepan
author_sort Basov, Alexander
collection PubMed
description The effect of single substitutions of protium for deuterium in hydrogen bonds between pairs of nitrogenous bases on the open states occurrence probability at high critical breaking energies of these bonds has been studied. The study was carried out using numerical methods based on the angular mathematical model of DNA. The IFNA17 gene was divided into three approximately equal parts. A comparison of the open states occurrence probability in these parts of the gene was done. To improve the accuracy of the results, a special data processing algorithm was developed. The developed methods have shown their suitability for taking into account the occurrence of open states in the entire range of high critical energies. It has been established that single (2)H/(1)H substitutions in certain nitrogenous bases can be a mechanism for maintaining the vital activity of IFNA17 under critical conditions. In general, the developed method of the mathematical modeling provide unprecedented insight into the DNA behavior under the highest critical energy range, which greatly expands scientific understanding of nucleobases interaction.
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spelling pubmed-97787622022-12-23 Influence of Single Deuterium Replacement on Frequency of Hydrogen Bond Dissociation in IFNA17 under the Highest Critical Energy Range Basov, Alexander Drobotenko, Mikhail Svidlov, Alexander Bezhenar, Maria Gerasimenko, Eugeny Moiseev, Arkadii Malyshko, Vadim Dorohova, Anna Drozdov, Andrey Baryshev, Mikhail Dzhimak, Stepan Int J Mol Sci Article The effect of single substitutions of protium for deuterium in hydrogen bonds between pairs of nitrogenous bases on the open states occurrence probability at high critical breaking energies of these bonds has been studied. The study was carried out using numerical methods based on the angular mathematical model of DNA. The IFNA17 gene was divided into three approximately equal parts. A comparison of the open states occurrence probability in these parts of the gene was done. To improve the accuracy of the results, a special data processing algorithm was developed. The developed methods have shown their suitability for taking into account the occurrence of open states in the entire range of high critical energies. It has been established that single (2)H/(1)H substitutions in certain nitrogenous bases can be a mechanism for maintaining the vital activity of IFNA17 under critical conditions. In general, the developed method of the mathematical modeling provide unprecedented insight into the DNA behavior under the highest critical energy range, which greatly expands scientific understanding of nucleobases interaction. MDPI 2022-12-07 /pmc/articles/PMC9778762/ /pubmed/36555136 http://dx.doi.org/10.3390/ijms232415487 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Basov, Alexander
Drobotenko, Mikhail
Svidlov, Alexander
Bezhenar, Maria
Gerasimenko, Eugeny
Moiseev, Arkadii
Malyshko, Vadim
Dorohova, Anna
Drozdov, Andrey
Baryshev, Mikhail
Dzhimak, Stepan
Influence of Single Deuterium Replacement on Frequency of Hydrogen Bond Dissociation in IFNA17 under the Highest Critical Energy Range
title Influence of Single Deuterium Replacement on Frequency of Hydrogen Bond Dissociation in IFNA17 under the Highest Critical Energy Range
title_full Influence of Single Deuterium Replacement on Frequency of Hydrogen Bond Dissociation in IFNA17 under the Highest Critical Energy Range
title_fullStr Influence of Single Deuterium Replacement on Frequency of Hydrogen Bond Dissociation in IFNA17 under the Highest Critical Energy Range
title_full_unstemmed Influence of Single Deuterium Replacement on Frequency of Hydrogen Bond Dissociation in IFNA17 under the Highest Critical Energy Range
title_short Influence of Single Deuterium Replacement on Frequency of Hydrogen Bond Dissociation in IFNA17 under the Highest Critical Energy Range
title_sort influence of single deuterium replacement on frequency of hydrogen bond dissociation in ifna17 under the highest critical energy range
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778762/
https://www.ncbi.nlm.nih.gov/pubmed/36555136
http://dx.doi.org/10.3390/ijms232415487
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