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Similarities and differences in constipation phenotypes between Lep knockout mice and high fat diet-induced obesity mice
CRISPR-Cas9-mediated leptin (Lep) knockout (KO) mice exhibited prominent phenotypes for constipation, even though they were not compared with other model animals. This study compared the stool excretion, gastrointestinal motility, histological structure, mucin secretion, and enteric nerve function i...
Autores principales: | Kim, Ji Eun, Seol, Ayun, Choi, Yun Ju, Lee, Su Jin, Jin, You Jeong, Roh, Yu Jeong, Song, Hee Jin, Hong, Jin Tae, Hwang, Dae Youn |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778951/ https://www.ncbi.nlm.nih.gov/pubmed/36548335 http://dx.doi.org/10.1371/journal.pone.0276445 |
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