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Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide

In Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients...

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Autores principales: Marcelino, Rute, Ezeonwumelu, Ifeanyi Jude, Janeiro, André, Mimoso, Paula, Matos, Sónia, Briz, Veronica, Pimentel, Victor, Pingarilho, Marta, Tato Marinho, Rui, Maria Marcelino, José, Taveira, Nuno, Abecasis, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778982/
https://www.ncbi.nlm.nih.gov/pubmed/36548381
http://dx.doi.org/10.1371/journal.pone.0276618
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author Marcelino, Rute
Ezeonwumelu, Ifeanyi Jude
Janeiro, André
Mimoso, Paula
Matos, Sónia
Briz, Veronica
Pimentel, Victor
Pingarilho, Marta
Tato Marinho, Rui
Maria Marcelino, José
Taveira, Nuno
Abecasis, Ana
author_facet Marcelino, Rute
Ezeonwumelu, Ifeanyi Jude
Janeiro, André
Mimoso, Paula
Matos, Sónia
Briz, Veronica
Pimentel, Victor
Pingarilho, Marta
Tato Marinho, Rui
Maria Marcelino, José
Taveira, Nuno
Abecasis, Ana
author_sort Marcelino, Rute
collection PubMed
description In Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients followed in Lisbon. HBV genotype A was the most prevalent (n = 54, 41.5%), followed by D (n = 44, 33.8%), and E (n = 32, 24.6%). Spatio-temporal evolutionary dynamics was reconstructed in BEAST using a Bayesian Markov Chain Monte Carlo method, with a GTR nucleotide substitution model, an uncorrelated lognormal relaxed molecular clock model, a Bayesian skyline plot, and a continuous diffusion model. HBV subgenotype D4 was the first to be introduced in Portugal around 1857 (HPD 95% 1699–1931) followed by D3 and A2 a few decades later. HBV genotype E and subgenotype A1 were introduced in Portugal later, almost simultaneously. Our results indicate a very important role of Portugal in the exportation of subgenotypes D4 and A2 to Brazil and Cape Verde, respectively, in the beginning of the XX century. This work clarifies the epidemiological history of HBV in Portugal and provides new insights in the early and global epidemic history of this virus.
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spelling pubmed-97789822022-12-23 Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide Marcelino, Rute Ezeonwumelu, Ifeanyi Jude Janeiro, André Mimoso, Paula Matos, Sónia Briz, Veronica Pimentel, Victor Pingarilho, Marta Tato Marinho, Rui Maria Marcelino, José Taveira, Nuno Abecasis, Ana PLoS One Research Article In Portugal, the genetic diversity, origin of HBV and the Portuguese role in the dissemination of HBV worldwide were never investigated. In this work, we studied the epidemic history and transmission dynamics of HBV genotypes that are endemic in Portugal. HBV pol gene was sequenced from 130 patients followed in Lisbon. HBV genotype A was the most prevalent (n = 54, 41.5%), followed by D (n = 44, 33.8%), and E (n = 32, 24.6%). Spatio-temporal evolutionary dynamics was reconstructed in BEAST using a Bayesian Markov Chain Monte Carlo method, with a GTR nucleotide substitution model, an uncorrelated lognormal relaxed molecular clock model, a Bayesian skyline plot, and a continuous diffusion model. HBV subgenotype D4 was the first to be introduced in Portugal around 1857 (HPD 95% 1699–1931) followed by D3 and A2 a few decades later. HBV genotype E and subgenotype A1 were introduced in Portugal later, almost simultaneously. Our results indicate a very important role of Portugal in the exportation of subgenotypes D4 and A2 to Brazil and Cape Verde, respectively, in the beginning of the XX century. This work clarifies the epidemiological history of HBV in Portugal and provides new insights in the early and global epidemic history of this virus. Public Library of Science 2022-12-22 /pmc/articles/PMC9778982/ /pubmed/36548381 http://dx.doi.org/10.1371/journal.pone.0276618 Text en © 2022 Marcelino et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Marcelino, Rute
Ezeonwumelu, Ifeanyi Jude
Janeiro, André
Mimoso, Paula
Matos, Sónia
Briz, Veronica
Pimentel, Victor
Pingarilho, Marta
Tato Marinho, Rui
Maria Marcelino, José
Taveira, Nuno
Abecasis, Ana
Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide
title Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide
title_full Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide
title_fullStr Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide
title_full_unstemmed Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide
title_short Phylogeography of hepatitis B virus: The role of Portugal in the early dissemination of HBV worldwide
title_sort phylogeography of hepatitis b virus: the role of portugal in the early dissemination of hbv worldwide
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9778982/
https://www.ncbi.nlm.nih.gov/pubmed/36548381
http://dx.doi.org/10.1371/journal.pone.0276618
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