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COVID-19 Not Hypertension or Diabetes Increases the Risk of Preeclampsia among a High-Risk Population

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection has been associated with greater morbidity and increased mortality in certain populations, such as those with chronic medical conditions, the elderly, and pregnant women. Our goal was to determine if COVID-19 infection during preg...

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Autores principales: Morris, Rachael, Moustafa, Ahmed S. Z., Kassahun-Yimer, Wondwosen, Novotny, Sarah, Billsby, Brittney, Abbas, Amira, Wallace, Kedra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779111/
https://www.ncbi.nlm.nih.gov/pubmed/36554511
http://dx.doi.org/10.3390/ijerph192416631
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author Morris, Rachael
Moustafa, Ahmed S. Z.
Kassahun-Yimer, Wondwosen
Novotny, Sarah
Billsby, Brittney
Abbas, Amira
Wallace, Kedra
author_facet Morris, Rachael
Moustafa, Ahmed S. Z.
Kassahun-Yimer, Wondwosen
Novotny, Sarah
Billsby, Brittney
Abbas, Amira
Wallace, Kedra
author_sort Morris, Rachael
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection has been associated with greater morbidity and increased mortality in certain populations, such as those with chronic medical conditions, the elderly, and pregnant women. Our goal was to determine if COVID-19 infection during pregnancy increased the risk of preeclampsia in a population of women with increased risk factors for preeclampsia. We present a prospective observational matched case–control study of 100 deliveries with confirmed SARS-CoV2. Specifically, we investigated the maternal and neonatal outcomes in a high-risk population of pregnant women. Among women with COVID-19, the severity of symptoms was associated with the incidence of preeclampsia, but not with pre-existing diabetes or hypertension. Women with more severe symptoms were more likely to delivery pre-term with smaller babies. After adjusting for diabetes, hypertensive women with COVID-19 had an increased risk of preeclampsia aOR4.3 [1.5,12.4] compared to non-hypertensive women with COVID-19. After adjusting for hypertension, women with diabetes and COVID-19 had an increased risk of preeclampsia aOR3.9 [1.2,12.5]. This relationship was not seen among women without COVID-19. For women who had pre-existing diabetes or hypertension, the risk of developing preeclampsia was only increased if they were also diagnosed with COVID-19, suggesting that in our population of women the risk of preeclampsia is not associated with pre-existing diabetes or hypertension.
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spelling pubmed-97791112022-12-23 COVID-19 Not Hypertension or Diabetes Increases the Risk of Preeclampsia among a High-Risk Population Morris, Rachael Moustafa, Ahmed S. Z. Kassahun-Yimer, Wondwosen Novotny, Sarah Billsby, Brittney Abbas, Amira Wallace, Kedra Int J Environ Res Public Health Article Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection has been associated with greater morbidity and increased mortality in certain populations, such as those with chronic medical conditions, the elderly, and pregnant women. Our goal was to determine if COVID-19 infection during pregnancy increased the risk of preeclampsia in a population of women with increased risk factors for preeclampsia. We present a prospective observational matched case–control study of 100 deliveries with confirmed SARS-CoV2. Specifically, we investigated the maternal and neonatal outcomes in a high-risk population of pregnant women. Among women with COVID-19, the severity of symptoms was associated with the incidence of preeclampsia, but not with pre-existing diabetes or hypertension. Women with more severe symptoms were more likely to delivery pre-term with smaller babies. After adjusting for diabetes, hypertensive women with COVID-19 had an increased risk of preeclampsia aOR4.3 [1.5,12.4] compared to non-hypertensive women with COVID-19. After adjusting for hypertension, women with diabetes and COVID-19 had an increased risk of preeclampsia aOR3.9 [1.2,12.5]. This relationship was not seen among women without COVID-19. For women who had pre-existing diabetes or hypertension, the risk of developing preeclampsia was only increased if they were also diagnosed with COVID-19, suggesting that in our population of women the risk of preeclampsia is not associated with pre-existing diabetes or hypertension. MDPI 2022-12-10 /pmc/articles/PMC9779111/ /pubmed/36554511 http://dx.doi.org/10.3390/ijerph192416631 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Morris, Rachael
Moustafa, Ahmed S. Z.
Kassahun-Yimer, Wondwosen
Novotny, Sarah
Billsby, Brittney
Abbas, Amira
Wallace, Kedra
COVID-19 Not Hypertension or Diabetes Increases the Risk of Preeclampsia among a High-Risk Population
title COVID-19 Not Hypertension or Diabetes Increases the Risk of Preeclampsia among a High-Risk Population
title_full COVID-19 Not Hypertension or Diabetes Increases the Risk of Preeclampsia among a High-Risk Population
title_fullStr COVID-19 Not Hypertension or Diabetes Increases the Risk of Preeclampsia among a High-Risk Population
title_full_unstemmed COVID-19 Not Hypertension or Diabetes Increases the Risk of Preeclampsia among a High-Risk Population
title_short COVID-19 Not Hypertension or Diabetes Increases the Risk of Preeclampsia among a High-Risk Population
title_sort covid-19 not hypertension or diabetes increases the risk of preeclampsia among a high-risk population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779111/
https://www.ncbi.nlm.nih.gov/pubmed/36554511
http://dx.doi.org/10.3390/ijerph192416631
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