Cell Therapy with Human Reprogrammed CD8(+) T-Cells Has Antimetastatic Effects on Lewis Lung Carcinoma in C57BL/6 Mice

Using a model of Lewis lung carcinoma (LLC) in vitro and in vivo, we previously demonstrated increased antitumor activity in CD8(+) T-cells reprogrammed with an MEK inhibitor and PD-1 blocker. In this follow-up study, we carried out the reprogramming of human CD8(+) T-cells (hrT-cell) using the MEK...

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Detalles Bibliográficos
Autores principales: Skurikhin, Evgenii G., Pershina, Olga, Ermakova, Natalia, Pakhomova, Angelina, Zhukova, Mariia, Pan, Edgar, Sandrikina, Lubov, Widera, Darius, Kogai, Lena, Kushlinskii, Nikolai, Kubatiev, Aslan, Morozov, Sergey G., Dygai, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779156/
https://www.ncbi.nlm.nih.gov/pubmed/36555420
http://dx.doi.org/10.3390/ijms232415780

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