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Comprehensive Analysis of the Association between Human Diseases and Water Pollutants

Drinking water is an important natural resource. For many people worldwide, especially in developing countries, access to safe drinking water is still a dream. An increasing number of human activities and industrialization have caused various physical, chemical, and biological pollutants to enter wa...

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Detalles Bibliográficos
Autores principales: Jiang, Xinlu, Zhang, Huanhuan, Wang, Xiaoyan, Zhang, Xu, Ding, Kaiyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779172/
https://www.ncbi.nlm.nih.gov/pubmed/36554354
http://dx.doi.org/10.3390/ijerph192416475
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author Jiang, Xinlu
Zhang, Huanhuan
Wang, Xiaoyan
Zhang, Xu
Ding, Kaiyang
author_facet Jiang, Xinlu
Zhang, Huanhuan
Wang, Xiaoyan
Zhang, Xu
Ding, Kaiyang
author_sort Jiang, Xinlu
collection PubMed
description Drinking water is an important natural resource. For many people worldwide, especially in developing countries, access to safe drinking water is still a dream. An increasing number of human activities and industrialization have caused various physical, chemical, and biological pollutants to enter water bodies, affecting human health. Water pollutants contain a vast number of additives, such as perfluorinated chemicals, polybrominated diphenyl ethers, phthalate, nanomaterials, insecticides, microcystins, heavy metals, and pharmacologies. In this work, we aim to explore the potential relationship between water pollutants and human diseases. Here, we explored an integrative approach to identify genes, biological processes, molecular functions, and diseases linked to exposure to these water pollutants. These processes and functions affected by water pollutants are related to many diseases, including colonic neoplasms, breast neoplasms, hepatitis B, bladder cancer, and human cytomegalovirus infection. In addition, further analysis revealed the genes that play a key role in the human diseases induced by water pollutants. Therefore, conducting an integrative toxicogenomic analysis of water pollutants is more appropriate for evaluating the potential effects of water pollutants on human health.
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spelling pubmed-97791722022-12-23 Comprehensive Analysis of the Association between Human Diseases and Water Pollutants Jiang, Xinlu Zhang, Huanhuan Wang, Xiaoyan Zhang, Xu Ding, Kaiyang Int J Environ Res Public Health Article Drinking water is an important natural resource. For many people worldwide, especially in developing countries, access to safe drinking water is still a dream. An increasing number of human activities and industrialization have caused various physical, chemical, and biological pollutants to enter water bodies, affecting human health. Water pollutants contain a vast number of additives, such as perfluorinated chemicals, polybrominated diphenyl ethers, phthalate, nanomaterials, insecticides, microcystins, heavy metals, and pharmacologies. In this work, we aim to explore the potential relationship between water pollutants and human diseases. Here, we explored an integrative approach to identify genes, biological processes, molecular functions, and diseases linked to exposure to these water pollutants. These processes and functions affected by water pollutants are related to many diseases, including colonic neoplasms, breast neoplasms, hepatitis B, bladder cancer, and human cytomegalovirus infection. In addition, further analysis revealed the genes that play a key role in the human diseases induced by water pollutants. Therefore, conducting an integrative toxicogenomic analysis of water pollutants is more appropriate for evaluating the potential effects of water pollutants on human health. MDPI 2022-12-08 /pmc/articles/PMC9779172/ /pubmed/36554354 http://dx.doi.org/10.3390/ijerph192416475 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jiang, Xinlu
Zhang, Huanhuan
Wang, Xiaoyan
Zhang, Xu
Ding, Kaiyang
Comprehensive Analysis of the Association between Human Diseases and Water Pollutants
title Comprehensive Analysis of the Association between Human Diseases and Water Pollutants
title_full Comprehensive Analysis of the Association between Human Diseases and Water Pollutants
title_fullStr Comprehensive Analysis of the Association between Human Diseases and Water Pollutants
title_full_unstemmed Comprehensive Analysis of the Association between Human Diseases and Water Pollutants
title_short Comprehensive Analysis of the Association between Human Diseases and Water Pollutants
title_sort comprehensive analysis of the association between human diseases and water pollutants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779172/
https://www.ncbi.nlm.nih.gov/pubmed/36554354
http://dx.doi.org/10.3390/ijerph192416475
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