Cargando…

Inhibition of E. coli RecQ Helicase Activity by Structurally Distinct DNA Lesions: Structure—Function Relationships

DNA helicase unwinding activity can be inhibited by small molecules and by covalently bound DNA lesions. Little is known about the relationships between the structural features of DNA lesions and their impact on unwinding rates and processivities. Employing E.coli RecQ helicase as a model system, an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sales, Ana H., Zheng, Vincent, Kenawy, Maya A., Kakembo, Mark, Zhang, Lu, Shafirovich, Vladimir, Broyde, Suse, Geacintov, Nicholas E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779537/ https://www.ncbi.nlm.nih.gov/pubmed/36555294 http://dx.doi.org/10.3390/ijms232415654

Ejemplares similares

Structural mechanisms of human RecQ helicases WRN and BLM
por: Kitano, Ken
Publicado: (2014)

RecQ Helicase Somatic Alterations in Cancer
por: Thakkar, Megha K., et al.
Publicado: (2022)

Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases
por: Sharma, Sudha
Publicado: (2011)

RecQ helicases: lessons from model organisms
por: Cobb, Jennifer A., et al.
Publicado: (2006)

RecQ helicases in DNA repair and cancer targets
por: Newman, Joseph A., et al.
Publicado: (2020)

Sit down, relax and unwind: structural insights into RecQ helicase mechanisms
por: Killoran, Michael P., et al.
Publicado: (2006)

Atomic structures and functional implications of the archaeal RecQ-like helicase Hjm
por: Oyama, Takuji, et al.
Publicado: (2009)

Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5
por: Newman, Joseph A., et al.
Publicado: (2017)

Human premature aging, DNA repair and RecQ helicases
por: Brosh, Robert M., et al.
Publicado: (2007)

Crystal Structure of Deinococcus radiodurans RecQ Helicase Catalytic Core Domain: The Interdomain Flexibility
por: Chen, Sheng-Chia, et al.
Publicado: (2014)

The structural and functional characterization of human RecQ4 reveals insights into its helicase mechanism
por: Kaiser, Sebastian, et al.
Publicado: (2017)

Mobility in the structure of E.coli recQ helicase upon substrate binding as seen from molecular dynamics simulations
por: Pandey, Nishtha, et al.
Publicado: (2011)

The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres
por: Mendez-Bermudez, Aaron, et al.
Publicado: (2012)

Maintenance of Yeast Genome Integrity by RecQ Family DNA Helicases
por: Gupta, Sonia Vidushi, et al.
Publicado: (2020)

Human RecQ Helicases in DNA Double-Strand Break Repair
por: Lu, Huiming, et al.
Publicado: (2021)

Genomic Instability of G-Quadruplex Sequences in Escherichia coli: Roles of DinG, RecG, and RecQ Helicases
por: Parekh, Virali J., et al.
Publicado: (2023)

Evidence That a RecQ Helicase Slows Senescence by Resolving Recombining Telomeres
por: Lee, Julia Y, et al.
Publicado: (2007)

Fork sensing and strand switching control antagonistic activities of RecQ helicases
por: Klaue, Daniel, et al.
Publicado: (2013)

RecQ helicase BLM regulates prostate cancer cell proliferation and apoptosis
por: Qian, Xiaosong, et al.
Publicado: (2017)

Molecular characteristics of reiterative DNA unwinding by the Caenorhabditis elegans RecQ helicase
por: Choi, Seoyun, et al.
Publicado: (2019)

Functional conservation of RecQ helicase BLM between humans and Drosophila melanogaster
por: Cox, Rebecca L., et al.
Publicado: (2019)

Targeting of RecQ Helicases as a Novel Therapeutic Strategy for Ovarian Cancer
por: Maity, Jyotirindra, et al.
Publicado: (2022)

Mechanism of lesion verification by the human XPD helicase in nucleotide excision repair
por: Fu, Iwen, et al.
Publicado: (2022)

Structural and biochemical characterization of an RNA/DNA binding motif in the N-terminal domain of RecQ4 helicases
por: Marino, Francesca, et al.
Publicado: (2016)

Yeast Hrq1 shares structural and functional homology with the disease-linked human RecQ4 helicase
por: Rogers, Cody M., et al.
Publicado: (2017)

Single molecule kinetics uncover roles for E. coli RecQ DNA helicase domains and interaction with SSB
por: Bagchi, Debjani, et al.
Publicado: (2018)

The Roles of the Saccharomyces cerevisiae RecQ Helicase SGS1 in Meiotic Genome Surveillance
por: Amin, Amit Dipak, et al.
Publicado: (2010)

The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability
por: Singh, Dharmendra Kumar, et al.
Publicado: (2012)

Relationships between putative G-quadruplex-forming sequences, RecQ helicases, and transcription
por: Smestad, John A., et al.
Publicado: (2015)

A guanine-flipping and sequestration mechanism for G-quadruplex unwinding by RecQ helicases
por: Voter, Andrew F., et al.
Publicado: (2018)

HERC2 inactivation abrogates nucleolar localization of RecQ helicases BLM and WRN
por: Zhu, Mingzhang, et al.
Publicado: (2021)

A telomerase-associated RecQ protein-like helicase resolves telomeric G-quadruplex structures during replication
por: Postberg, Jan, et al.
Publicado: (2012)

The RecQ helicase Sgs1 drives ATP-dependent disruption of Rad51 filaments
por: Crickard, J Brooks, et al.
Publicado: (2019)

Homology sensing via non-linear amplification of sequence-dependent pausing by RecQ helicase
por: Seol, Yeonee, et al.
Publicado: (2019)

Nanopore tweezers measurements of RecQ conformational changes reveal the energy landscape of helicase motion
por: Craig, Jonathan M, et al.
Publicado: (2022)

The Extraintestinal Pathogenic Escherichia coli Factor RqlI Constrains the Genotoxic Effects of the RecQ-Like Helicase RqlH
por: Russell, Colin W., et al.
Publicado: (2015)

Structure of the RecQ C-terminal Domain of Human Bloom Syndrome Protein
por: Kim, Sun-Yong, et al.
Publicado: (2013)

Low expression of RecQ-like helicase 5 is associated with poor prognosis in patients with gastric cancer
por: Lin, Yijia, et al.
Publicado: (2020)

Structural basis for the recognition of diastereomeric 5′,8-cyclo-2′-deoxypurine lesions by the human nucleotide excision repair system
por: Kropachev, Konstantin, et al.
Publicado: (2014)

Repair-Resistant DNA Lesions
por: Geacintov, Nicholas E., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_n1t9kdc8l9008auqujcom5qrcn