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A Retrospective Assessment of Thrombophilia in Pregnant Women with First and Second Trimester Pregnancy Loss

Recurrent Pregnancy Loss (RPL) affects between 1% to 5% of women of reproductive age. It is widely believed that RPL is a complex disorder that is influenced by chromosomal abnormalities, genetic mutations, uterine anatomic deformity, endocrine dysfunction, immunologic factors, infections, and the e...

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Autores principales: Iordache, Olivera, Anastasiu-Popov, Diana Maria, Anastasiu, Doru Mihai, Craina, Marius, Dahma, George, Sacarin, Geanina, Silaghi, Carmen, Citu, Cosmin, Daniluc, Razvan, Hinoveanu, Denisa, Feciche, Bogdan, Bratosin, Felix, Neamtu, Radu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779542/
https://www.ncbi.nlm.nih.gov/pubmed/36554381
http://dx.doi.org/10.3390/ijerph192416500
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author Iordache, Olivera
Anastasiu-Popov, Diana Maria
Anastasiu, Doru Mihai
Craina, Marius
Dahma, George
Sacarin, Geanina
Silaghi, Carmen
Citu, Cosmin
Daniluc, Razvan
Hinoveanu, Denisa
Feciche, Bogdan
Bratosin, Felix
Neamtu, Radu
author_facet Iordache, Olivera
Anastasiu-Popov, Diana Maria
Anastasiu, Doru Mihai
Craina, Marius
Dahma, George
Sacarin, Geanina
Silaghi, Carmen
Citu, Cosmin
Daniluc, Razvan
Hinoveanu, Denisa
Feciche, Bogdan
Bratosin, Felix
Neamtu, Radu
author_sort Iordache, Olivera
collection PubMed
description Recurrent Pregnancy Loss (RPL) affects between 1% to 5% of women of reproductive age. It is widely believed that RPL is a complex disorder that is influenced by chromosomal abnormalities, genetic mutations, uterine anatomic deformity, endocrine dysfunction, immunologic factors, infections, and the environment. Thrombotic disorders are a frequent cause of RPL, accounting for almost half of all cases; however, in the rest of the cases, the cause of RPL remains unclear. Therefore, in this study, it was planned to determine the genetic mutations involved in RPL during the first and second trimester of pregnancy. An observational retrospective cohort study was conducted in 2021, collecting data from 157 first trimester miscarriages and 54 s trimester pregnancies. All patients with a panel of laboratory and genetic analysis for thrombophilia were included for data analysis. It was observed that four factors were significantly more prevalent in one of the groups. Factor V Leiden (FVL) homozygosity and antiphospholipid syndrome (APS) antibodies were statistically significantly more common in pregnant women who suffered first trimester pregnancy losses. On the other hand, Protein C deficiency and Glycoprotein Ia polymorphism were statistically significantly more frequent in the second trimester group. The strongest independent risk factors for first trimester pregnancy loss were FVL and prothrombin (PT) compound mutations (OR = 3.11), followed by FVL homozygous mutation (OR = 3.66), and APS antibodies (OR = 4.47). Regarding second trimester pregnancy loss risk factors, the strongest were FVL and PT compound (OR = 3.24), followed by Glycoprotein Ia polymorphism (OR = 3.61), and respectively, APS antibodies (OR = 3.85). Numerous thrombophilic risk factors for early and late pregnancy loss have been found, including several mutations that seem to occur more often either during the first or the second trimester. Even though we are aware of risk-free and efficient diagnostics for thrombophilia abnormalities, no intervention has been proved to be clearly successful after the detection of these variables.
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spelling pubmed-97795422022-12-23 A Retrospective Assessment of Thrombophilia in Pregnant Women with First and Second Trimester Pregnancy Loss Iordache, Olivera Anastasiu-Popov, Diana Maria Anastasiu, Doru Mihai Craina, Marius Dahma, George Sacarin, Geanina Silaghi, Carmen Citu, Cosmin Daniluc, Razvan Hinoveanu, Denisa Feciche, Bogdan Bratosin, Felix Neamtu, Radu Int J Environ Res Public Health Article Recurrent Pregnancy Loss (RPL) affects between 1% to 5% of women of reproductive age. It is widely believed that RPL is a complex disorder that is influenced by chromosomal abnormalities, genetic mutations, uterine anatomic deformity, endocrine dysfunction, immunologic factors, infections, and the environment. Thrombotic disorders are a frequent cause of RPL, accounting for almost half of all cases; however, in the rest of the cases, the cause of RPL remains unclear. Therefore, in this study, it was planned to determine the genetic mutations involved in RPL during the first and second trimester of pregnancy. An observational retrospective cohort study was conducted in 2021, collecting data from 157 first trimester miscarriages and 54 s trimester pregnancies. All patients with a panel of laboratory and genetic analysis for thrombophilia were included for data analysis. It was observed that four factors were significantly more prevalent in one of the groups. Factor V Leiden (FVL) homozygosity and antiphospholipid syndrome (APS) antibodies were statistically significantly more common in pregnant women who suffered first trimester pregnancy losses. On the other hand, Protein C deficiency and Glycoprotein Ia polymorphism were statistically significantly more frequent in the second trimester group. The strongest independent risk factors for first trimester pregnancy loss were FVL and prothrombin (PT) compound mutations (OR = 3.11), followed by FVL homozygous mutation (OR = 3.66), and APS antibodies (OR = 4.47). Regarding second trimester pregnancy loss risk factors, the strongest were FVL and PT compound (OR = 3.24), followed by Glycoprotein Ia polymorphism (OR = 3.61), and respectively, APS antibodies (OR = 3.85). Numerous thrombophilic risk factors for early and late pregnancy loss have been found, including several mutations that seem to occur more often either during the first or the second trimester. Even though we are aware of risk-free and efficient diagnostics for thrombophilia abnormalities, no intervention has been proved to be clearly successful after the detection of these variables. MDPI 2022-12-08 /pmc/articles/PMC9779542/ /pubmed/36554381 http://dx.doi.org/10.3390/ijerph192416500 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iordache, Olivera
Anastasiu-Popov, Diana Maria
Anastasiu, Doru Mihai
Craina, Marius
Dahma, George
Sacarin, Geanina
Silaghi, Carmen
Citu, Cosmin
Daniluc, Razvan
Hinoveanu, Denisa
Feciche, Bogdan
Bratosin, Felix
Neamtu, Radu
A Retrospective Assessment of Thrombophilia in Pregnant Women with First and Second Trimester Pregnancy Loss
title A Retrospective Assessment of Thrombophilia in Pregnant Women with First and Second Trimester Pregnancy Loss
title_full A Retrospective Assessment of Thrombophilia in Pregnant Women with First and Second Trimester Pregnancy Loss
title_fullStr A Retrospective Assessment of Thrombophilia in Pregnant Women with First and Second Trimester Pregnancy Loss
title_full_unstemmed A Retrospective Assessment of Thrombophilia in Pregnant Women with First and Second Trimester Pregnancy Loss
title_short A Retrospective Assessment of Thrombophilia in Pregnant Women with First and Second Trimester Pregnancy Loss
title_sort retrospective assessment of thrombophilia in pregnant women with first and second trimester pregnancy loss
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779542/
https://www.ncbi.nlm.nih.gov/pubmed/36554381
http://dx.doi.org/10.3390/ijerph192416500
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