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Protein-Based Oncopanel as Addition to Target Sequencing in Head and Neck Squamous Cell Carcinoma to Individualize Treatment Decisions
Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of cancers and patients have limited therapy options if primary treatment fails. Therefore, additional information about the biology of the tumor is essential. Here we performed a feasibility study of concurrently applying two pr...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779552/ https://www.ncbi.nlm.nih.gov/pubmed/36555474 http://dx.doi.org/10.3390/ijms232415835 |
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author | von Witzleben, Adrian Müller-Richter, Urs Maurus, Katja Brändlein, Stephanie Theodoraki, Marie-Nicole Brunner, Cornelia Laban, Simon Lennerz, Jochen Möller, Peter Hoffmann, Thomas K. Doescher, Johannes Schuler, Patrick J. |
author_facet | von Witzleben, Adrian Müller-Richter, Urs Maurus, Katja Brändlein, Stephanie Theodoraki, Marie-Nicole Brunner, Cornelia Laban, Simon Lennerz, Jochen Möller, Peter Hoffmann, Thomas K. Doescher, Johannes Schuler, Patrick J. |
author_sort | von Witzleben, Adrian |
collection | PubMed |
description | Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of cancers and patients have limited therapy options if primary treatment fails. Therefore, additional information about the biology of the tumor is essential. Here we performed a feasibility study of concurrently applying two precision diagnostic tools in a consecutive series of HNSCC patients. We analyzed tumor samples of 31 patients using a genomic (oncomine) and a proteomic, immunohistochemical approach (oncopanel) and compared the result, also in the focus on their overlapping therapeutical targets. We found no strong correlation between the two approaches and observed a higher proportion of marker expression for the immunohistochemical panel. However, both panels show in our HNSCC cohort distinct patterns with druggable targets. The data suggest that both approaches complement one another and can be applied side-by-side to identify the best targets for the development of individual treatment options for HNSCC patients. |
format | Online Article Text |
id | pubmed-9779552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97795522022-12-23 Protein-Based Oncopanel as Addition to Target Sequencing in Head and Neck Squamous Cell Carcinoma to Individualize Treatment Decisions von Witzleben, Adrian Müller-Richter, Urs Maurus, Katja Brändlein, Stephanie Theodoraki, Marie-Nicole Brunner, Cornelia Laban, Simon Lennerz, Jochen Möller, Peter Hoffmann, Thomas K. Doescher, Johannes Schuler, Patrick J. Int J Mol Sci Article Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous group of cancers and patients have limited therapy options if primary treatment fails. Therefore, additional information about the biology of the tumor is essential. Here we performed a feasibility study of concurrently applying two precision diagnostic tools in a consecutive series of HNSCC patients. We analyzed tumor samples of 31 patients using a genomic (oncomine) and a proteomic, immunohistochemical approach (oncopanel) and compared the result, also in the focus on their overlapping therapeutical targets. We found no strong correlation between the two approaches and observed a higher proportion of marker expression for the immunohistochemical panel. However, both panels show in our HNSCC cohort distinct patterns with druggable targets. The data suggest that both approaches complement one another and can be applied side-by-side to identify the best targets for the development of individual treatment options for HNSCC patients. MDPI 2022-12-13 /pmc/articles/PMC9779552/ /pubmed/36555474 http://dx.doi.org/10.3390/ijms232415835 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article von Witzleben, Adrian Müller-Richter, Urs Maurus, Katja Brändlein, Stephanie Theodoraki, Marie-Nicole Brunner, Cornelia Laban, Simon Lennerz, Jochen Möller, Peter Hoffmann, Thomas K. Doescher, Johannes Schuler, Patrick J. Protein-Based Oncopanel as Addition to Target Sequencing in Head and Neck Squamous Cell Carcinoma to Individualize Treatment Decisions |
title | Protein-Based Oncopanel as Addition to Target Sequencing in Head and Neck Squamous Cell Carcinoma to Individualize Treatment Decisions |
title_full | Protein-Based Oncopanel as Addition to Target Sequencing in Head and Neck Squamous Cell Carcinoma to Individualize Treatment Decisions |
title_fullStr | Protein-Based Oncopanel as Addition to Target Sequencing in Head and Neck Squamous Cell Carcinoma to Individualize Treatment Decisions |
title_full_unstemmed | Protein-Based Oncopanel as Addition to Target Sequencing in Head and Neck Squamous Cell Carcinoma to Individualize Treatment Decisions |
title_short | Protein-Based Oncopanel as Addition to Target Sequencing in Head and Neck Squamous Cell Carcinoma to Individualize Treatment Decisions |
title_sort | protein-based oncopanel as addition to target sequencing in head and neck squamous cell carcinoma to individualize treatment decisions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779552/ https://www.ncbi.nlm.nih.gov/pubmed/36555474 http://dx.doi.org/10.3390/ijms232415835 |
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