Cargando…

Loss of Myostatin Alters Mitochondrial Oxidative Phosphorylation, TCA Cycle Activity, and ATP Production in Skeletal Muscle

SIMPLE SUMMARY: Myostatin (MSTN) negatively regulates skeletal muscle growth. Although the role of MSTN in muscle hypertrophy can be investigated in depth, studies of MSTN in mitochondrial energy metabolism in muscle would be valuable. In this study, we evaluated the importance of MSTN in regulating...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Xueqiao, Wei, Zhuying, Gu, Mingjuan, Zhu, Lin, Hai, Chao, Di, Anqi, Wu, Di, Bai, Chunling, Su, Guanghua, Liu, Xuefei, Yang, Lei, Li, Guangpeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779574/ https://www.ncbi.nlm.nih.gov/pubmed/36555347 http://dx.doi.org/10.3390/ijms232415707

Ejemplares similares

Myostatin Knockout Affects Mitochondrial Function by Inhibiting the AMPK/SIRT1/PGC1α Pathway in Skeletal Muscle
por: Gu, Mingjuan, et al.
Publicado: (2022)

Myostatin Knockout Limits Exercise-Induced Reduction in Bovine Erythrocyte Oxidative Stress by Enhancing the Efficiency of the Pentose Phosphate Pathway
por: Zhu, Lin, et al.
Publicado: (2022)

Myostatin Knockout Regulates Bile Acid Metabolism by Promoting Bile Acid Synthesis in Cattle
por: Wu, Di, et al.
Publicado: (2022)

Combined Transcriptome and Metabolome Analysis of Smooth Muscle of Myostatin Knockout Cattle
por: Gu, Mingjuan, et al.
Publicado: (2023)

Comparison of Microbial Community and Metabolites in Four Stomach Compartments of Myostatin-Gene-Edited and Non-edited Cattle
por: Zhou, Xinyu, et al.
Publicado: (2022)

Myostatin Deficiency Enhances Antioxidant Capacity of Bovine Muscle via the SMAD-AMPK-G6PD Pathway
por: Zhu, Lin, et al.
Publicado: (2022)

N-3 Polyunsaturated Fatty Acid Dehydrogenase Fat-1 Regulates Mitochondrial Energy Metabolism by Altering DNA Methylation in Isolated Cells of Transgenic Cattle
por: Wang, Xueqiao, et al.
Publicado: (2022)

Growth Traits and Sperm Proteomics Analyses of Myostatin Gene-Edited Chinese Yellow Cattle
por: Zhao, Yuefang, et al.
Publicado: (2022)

Effects of Different Generations and Sex on Physiological, Biochemical, and Growth Parameters of Crossbred Beef Cattle by Myostatin Gene-Edited Luxi Bulls and Simmental Cows
por: Hai, Chao, et al.
Publicado: (2023)

Myostatin Mutation Promotes Glycolysis by Increasing Phosphorylation of Phosphofructokinase via Activation of PDE5A-cGMP-PKG in Cattle Heart
por: Gu, Mingjuan, et al.
Publicado: (2022)

Histone Demethylase UTX is an Essential Factor for Zygotic Genome Activation and Regulates Zscan4 Expression in Mouse Embryos
por: Bai, Lige, et al.
Publicado: (2019)

Mitochondrial metabolism in TCA cycle mutant cancer cells
por: Sullivan, Lucas B, et al.
Publicado: (2014)

Mitochondrial TCA cycle metabolites control physiology and disease
por: Martínez-Reyes, Inmaculada, et al.
Publicado: (2020)

Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis
por: Cai, Zhen, et al.
Publicado: (2020)

Low Expression of Mitofusin 1 Gene Leads to Mitochondrial Dysfunction and Embryonic Genome Activation Failure in Ovine-Bovine Inter-Species Cloned Embryos
por: Wu, Shanshan, et al.
Publicado: (2022)

Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle
por: Tournaire, Guillaume, et al.
Publicado: (2022)

MSTN Mutant Promotes Myogenic Differentiation by Increasing Demethylase TET1 Expression via the SMAD2/SMAD3 Pathway
por: Gao, Li, et al.
Publicado: (2020)

Omega 3 polyunsaturated fatty acids inhibit cell proliferation by regulating cell cycle in fad3b transgenic mouse embryonic stem cells
por: Wei, Zhuying, et al.
Publicado: (2018)

Proteomic Studies on the Mechanism of Myostatin Regulating Cattle Skeletal Muscle Development
por: Sheng, Hui, et al.
Publicado: (2021)

Exploring timing activation of functional pathway based on differential co-expression analysis in preimplantation embryogenesis
por: Zuo, Yongchun, et al.
Publicado: (2016)

GATOR1 regulates nitrogenic cataplerotic reactions of the mitochondrial TCA cycle
por: Chen, Jun, et al.
Publicado: (2017)

AMPK maintains TCA cycle through sequential phosphorylation of PDHA to promote tumor metastasis
por: Cai, Zhen, et al.
Publicado: (2020)

Changes in TCA cycle and TCA cycle-related metabolites in plasma upon citric acid administration in rats
por: Hara, Yurie, et al.
Publicado: (2021)

Myostatin in the Pathophysiology of Skeletal Muscle
por: Carnac, Gilles, et al.
Publicado: (2007)

Skeletal muscle mitochondrial bioenergetics and associations with myostatin genotypes in the Thoroughbred horse
por: Rooney, Mary F., et al.
Publicado: (2017)

Irregular transcriptome reprogramming probably causes thec developmental failure of embryos produced by interspecies somatic cell nuclear transfer between the Przewalski’s gazelle and the bovine
por: Zuo, Yongchun, et al.
Publicado: (2014)

Coexpression analysis identifies nuclear reprogramming barriers of somatic cell nuclear transfer embryos
por: Zuo, Yongchun, et al.
Publicado: (2017)

DNA methylation subpatterns at distinct regulatory regions in human early embryos
por: Luo, Rongsong, et al.
Publicado: (2018)

Correction to ‘DNA methylation subpatterns at distinct regulatory regions in human early embryos’
por: Luo, Rongsong, et al.
Publicado: (2018)

Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles
por: Yamano, Emi, et al.
Publicado: (2016)

DNMT 1 maintains hypermethylation of CAG promoter specific region and prevents expression of exogenous gene in fat-1 transgenic sheep
por: Yang, Chunrong, et al.
Publicado: (2017)

MicroTCA and AdvancedTCA equipment evaluation and customization for LHC experiments
por: Cosmo, M Di, et al.
Publicado: (2015)

Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation
por: Li, Wei, et al.
Publicado: (2022)

Rescue of TCA Cycle Dysfunction for Cancer Therapy
por: Marquez, Jubert, et al.
Publicado: (2019)

Identification and characterization of the TCA cycle genes in maize
por: Liu, Yongming, et al.
Publicado: (2019)

Myostatin: A Skeletal Muscle Chalone
por: Lee, Se-Jin
Publicado: (2023)

TCA cycle rewiring fosters metabolic adaptation to oxygen restriction in skeletal muscle from rodents and humans
por: Capitanio, Daniele, et al.
Publicado: (2017)

Microarray Analysis of the Gene Expression Profile and Lipid Metabolism in Fat-1 Transgenic Cattle
por: Liu, Xinfeng, et al.
Publicado: (2015)

Boosted TCA cycle enhances survival of zebrafish to Vibrio alginolyticus infection
por: Yang, Man-Jun, et al.
Publicado: (2018)

Parallel comparative proteomics and phosphoproteomics reveal that cattle myostatin regulates phosphorylation of key enzymes in glycogen metabolism and glycolysis pathway
por: Yang, Shuping, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_p1lfcqa3mbrjfqc8ln41t100ug