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Distribution of KIR Genes and Their HLA Ligands in Different Viral Infectious Diseases: Frequency Study in Sicilian Population

Natural killer (NK) cells play a role in defence against viral infections by killing infected cells or by producing cytokines and interacting with adaptive immune cells. Killer immunoglobulin-like receptors (KIRs) regulate the activation of NK cells through their interaction with human leucocyte ant...

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Autores principales: Ligotti, Mattia Emanuela, Aiello, Anna, Accardi, Giulia, Calabrò, Anna, Ciaccio, Marcello, Colomba, Claudia, Di Bona, Danilo, Lo Sasso, Bruna, Pojero, Fanny, Tuttolomondo, Antonino, Caruso, Calogero, Candore, Giuseppina, Duro, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779783/
https://www.ncbi.nlm.nih.gov/pubmed/36555106
http://dx.doi.org/10.3390/ijms232415466
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author Ligotti, Mattia Emanuela
Aiello, Anna
Accardi, Giulia
Calabrò, Anna
Ciaccio, Marcello
Colomba, Claudia
Di Bona, Danilo
Lo Sasso, Bruna
Pojero, Fanny
Tuttolomondo, Antonino
Caruso, Calogero
Candore, Giuseppina
Duro, Giovanni
author_facet Ligotti, Mattia Emanuela
Aiello, Anna
Accardi, Giulia
Calabrò, Anna
Ciaccio, Marcello
Colomba, Claudia
Di Bona, Danilo
Lo Sasso, Bruna
Pojero, Fanny
Tuttolomondo, Antonino
Caruso, Calogero
Candore, Giuseppina
Duro, Giovanni
author_sort Ligotti, Mattia Emanuela
collection PubMed
description Natural killer (NK) cells play a role in defence against viral infections by killing infected cells or by producing cytokines and interacting with adaptive immune cells. Killer immunoglobulin-like receptors (KIRs) regulate the activation of NK cells through their interaction with human leucocyte antigens (HLA). Ninety-six Sicilian patients positive to Human Immunodeficiency Virus-1 (HIV) and ninety-two Sicilian patients positive to SARS-CoV-2 were genotyped for KIRs and their HLA ligands. We also included fifty-six Sicilian patients with chronic hepatitis B (CHB) already recruited in our previous study. The aim of this study was to compare the distribution of KIR–HLA genes/groups of these three different infected populations with healthy Sicilian donors from the literature. We showed that the inhibitory KIR3DL1 gene and the KIR3DL1/HLA-B Bw4 pairing were more prevalent in individual CHB. At the same time, the frequency of HLA-C2 was increased in CHB compared to other groups. In contrast, the HLA-C1 ligand seems to have no contribution to CHB progression whereas it was significantly higher in COVID-19 and HIV-positive than healthy controls. These results suggest that specific KIR–HLA combinations can predict the outcome/susceptibility of these viral infections and allows to plan successful customized therapeutic strategies.
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spelling pubmed-97797832022-12-23 Distribution of KIR Genes and Their HLA Ligands in Different Viral Infectious Diseases: Frequency Study in Sicilian Population Ligotti, Mattia Emanuela Aiello, Anna Accardi, Giulia Calabrò, Anna Ciaccio, Marcello Colomba, Claudia Di Bona, Danilo Lo Sasso, Bruna Pojero, Fanny Tuttolomondo, Antonino Caruso, Calogero Candore, Giuseppina Duro, Giovanni Int J Mol Sci Article Natural killer (NK) cells play a role in defence against viral infections by killing infected cells or by producing cytokines and interacting with adaptive immune cells. Killer immunoglobulin-like receptors (KIRs) regulate the activation of NK cells through their interaction with human leucocyte antigens (HLA). Ninety-six Sicilian patients positive to Human Immunodeficiency Virus-1 (HIV) and ninety-two Sicilian patients positive to SARS-CoV-2 were genotyped for KIRs and their HLA ligands. We also included fifty-six Sicilian patients with chronic hepatitis B (CHB) already recruited in our previous study. The aim of this study was to compare the distribution of KIR–HLA genes/groups of these three different infected populations with healthy Sicilian donors from the literature. We showed that the inhibitory KIR3DL1 gene and the KIR3DL1/HLA-B Bw4 pairing were more prevalent in individual CHB. At the same time, the frequency of HLA-C2 was increased in CHB compared to other groups. In contrast, the HLA-C1 ligand seems to have no contribution to CHB progression whereas it was significantly higher in COVID-19 and HIV-positive than healthy controls. These results suggest that specific KIR–HLA combinations can predict the outcome/susceptibility of these viral infections and allows to plan successful customized therapeutic strategies. MDPI 2022-12-07 /pmc/articles/PMC9779783/ /pubmed/36555106 http://dx.doi.org/10.3390/ijms232415466 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ligotti, Mattia Emanuela
Aiello, Anna
Accardi, Giulia
Calabrò, Anna
Ciaccio, Marcello
Colomba, Claudia
Di Bona, Danilo
Lo Sasso, Bruna
Pojero, Fanny
Tuttolomondo, Antonino
Caruso, Calogero
Candore, Giuseppina
Duro, Giovanni
Distribution of KIR Genes and Their HLA Ligands in Different Viral Infectious Diseases: Frequency Study in Sicilian Population
title Distribution of KIR Genes and Their HLA Ligands in Different Viral Infectious Diseases: Frequency Study in Sicilian Population
title_full Distribution of KIR Genes and Their HLA Ligands in Different Viral Infectious Diseases: Frequency Study in Sicilian Population
title_fullStr Distribution of KIR Genes and Their HLA Ligands in Different Viral Infectious Diseases: Frequency Study in Sicilian Population
title_full_unstemmed Distribution of KIR Genes and Their HLA Ligands in Different Viral Infectious Diseases: Frequency Study in Sicilian Population
title_short Distribution of KIR Genes and Their HLA Ligands in Different Viral Infectious Diseases: Frequency Study in Sicilian Population
title_sort distribution of kir genes and their hla ligands in different viral infectious diseases: frequency study in sicilian population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779783/
https://www.ncbi.nlm.nih.gov/pubmed/36555106
http://dx.doi.org/10.3390/ijms232415466
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