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Increased Oxidative Stress Markers in Acute Ischemic Stroke Patients Treated with Thrombolytics

One of the most common neurological disorders involving oxidative stress is stroke. During a stroke, the balance of redox potential in the cell is disturbed, and, consequently, protein oxidation or other intracellular damage occurs, ultimately leading to apoptosis. The pineal gland hormone, melatoni...

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Autores principales: Pawluk, Hanna, Kołodziejska, Renata, Grześk, Grzegorz, Woźniak, Alina, Kozakiewicz, Mariusz, Kosinska, Agnieszka, Pawluk, Mateusz, Grzechowiak, Elżbieta, Wojtasik, Jakub, Kozera, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779811/
https://www.ncbi.nlm.nih.gov/pubmed/36555265
http://dx.doi.org/10.3390/ijms232415625
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author Pawluk, Hanna
Kołodziejska, Renata
Grześk, Grzegorz
Woźniak, Alina
Kozakiewicz, Mariusz
Kosinska, Agnieszka
Pawluk, Mateusz
Grzechowiak, Elżbieta
Wojtasik, Jakub
Kozera, Grzegorz
author_facet Pawluk, Hanna
Kołodziejska, Renata
Grześk, Grzegorz
Woźniak, Alina
Kozakiewicz, Mariusz
Kosinska, Agnieszka
Pawluk, Mateusz
Grzechowiak, Elżbieta
Wojtasik, Jakub
Kozera, Grzegorz
author_sort Pawluk, Hanna
collection PubMed
description One of the most common neurological disorders involving oxidative stress is stroke. During a stroke, the balance of redox potential in the cell is disturbed, and, consequently, protein oxidation or other intracellular damage occurs, ultimately leading to apoptosis. The pineal gland hormone, melatonin, is one of the non-enzymatic antioxidants. It not only modulates the perianal rhythm but also has anti-inflammatory properties and protects against stress-induced changes. The focus of this research was to evaluate the concentration of the carbonyl groups and melatonin metabolite in time in patients with acute ischemic stroke that were treated with intravenous thrombolysis. This included a comparison of the functional status of patients assessed according to neurological scales with the control sample comprising healthy people. The studies showed that the serum concentrations of carbonyl groups, which were elevated in patients with ischemic stroke (AIS) in comparison to the control samples, had an impact on the patients’ outcome. A urine concentration of the melatonin metabolite, which was lower in patients than controls, was related to functional status after 24 h from cerebral thrombolysis. It shows that determination of carbonyl groups at different time intervals may be an important potential marker of protein damage in patients with AIS treated with cerebral thrombolysis, and that impaired melatonin metabolism induces a low antioxidant protection. Thus, due to the neuroprotective effects of melatonin, attention should also be paid to the design and conduct of clinical trials and hormone supplementation in AIS patients to understand the interactions between exogenous melatonin and its endogenous rhythm, as well as how these relationships may affect patient outcomes.
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spelling pubmed-97798112022-12-23 Increased Oxidative Stress Markers in Acute Ischemic Stroke Patients Treated with Thrombolytics Pawluk, Hanna Kołodziejska, Renata Grześk, Grzegorz Woźniak, Alina Kozakiewicz, Mariusz Kosinska, Agnieszka Pawluk, Mateusz Grzechowiak, Elżbieta Wojtasik, Jakub Kozera, Grzegorz Int J Mol Sci Article One of the most common neurological disorders involving oxidative stress is stroke. During a stroke, the balance of redox potential in the cell is disturbed, and, consequently, protein oxidation or other intracellular damage occurs, ultimately leading to apoptosis. The pineal gland hormone, melatonin, is one of the non-enzymatic antioxidants. It not only modulates the perianal rhythm but also has anti-inflammatory properties and protects against stress-induced changes. The focus of this research was to evaluate the concentration of the carbonyl groups and melatonin metabolite in time in patients with acute ischemic stroke that were treated with intravenous thrombolysis. This included a comparison of the functional status of patients assessed according to neurological scales with the control sample comprising healthy people. The studies showed that the serum concentrations of carbonyl groups, which were elevated in patients with ischemic stroke (AIS) in comparison to the control samples, had an impact on the patients’ outcome. A urine concentration of the melatonin metabolite, which was lower in patients than controls, was related to functional status after 24 h from cerebral thrombolysis. It shows that determination of carbonyl groups at different time intervals may be an important potential marker of protein damage in patients with AIS treated with cerebral thrombolysis, and that impaired melatonin metabolism induces a low antioxidant protection. Thus, due to the neuroprotective effects of melatonin, attention should also be paid to the design and conduct of clinical trials and hormone supplementation in AIS patients to understand the interactions between exogenous melatonin and its endogenous rhythm, as well as how these relationships may affect patient outcomes. MDPI 2022-12-09 /pmc/articles/PMC9779811/ /pubmed/36555265 http://dx.doi.org/10.3390/ijms232415625 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pawluk, Hanna
Kołodziejska, Renata
Grześk, Grzegorz
Woźniak, Alina
Kozakiewicz, Mariusz
Kosinska, Agnieszka
Pawluk, Mateusz
Grzechowiak, Elżbieta
Wojtasik, Jakub
Kozera, Grzegorz
Increased Oxidative Stress Markers in Acute Ischemic Stroke Patients Treated with Thrombolytics
title Increased Oxidative Stress Markers in Acute Ischemic Stroke Patients Treated with Thrombolytics
title_full Increased Oxidative Stress Markers in Acute Ischemic Stroke Patients Treated with Thrombolytics
title_fullStr Increased Oxidative Stress Markers in Acute Ischemic Stroke Patients Treated with Thrombolytics
title_full_unstemmed Increased Oxidative Stress Markers in Acute Ischemic Stroke Patients Treated with Thrombolytics
title_short Increased Oxidative Stress Markers in Acute Ischemic Stroke Patients Treated with Thrombolytics
title_sort increased oxidative stress markers in acute ischemic stroke patients treated with thrombolytics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779811/
https://www.ncbi.nlm.nih.gov/pubmed/36555265
http://dx.doi.org/10.3390/ijms232415625
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