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Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung
Immune checkpoint inhibitors are associated with a spectrum of cutaneous immune-related adverse events. While maculopapular eruptions are the most common cutaneous adverse event, scleroderma can rarely develop. Herein, we report a case of new-onset scleroderma associated with avelumab treatment in t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779987/ https://www.ncbi.nlm.nih.gov/pubmed/36567751 http://dx.doi.org/10.1155/2022/5360113 |
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author | Dobrzynski, Jeffrey L. Vest, Blake E. Swick, Brian L. |
author_facet | Dobrzynski, Jeffrey L. Vest, Blake E. Swick, Brian L. |
author_sort | Dobrzynski, Jeffrey L. |
collection | PubMed |
description | Immune checkpoint inhibitors are associated with a spectrum of cutaneous immune-related adverse events. While maculopapular eruptions are the most common cutaneous adverse event, scleroderma can rarely develop. Herein, we report a case of new-onset scleroderma associated with avelumab treatment in the setting of metastatic squamous cell carcinoma of the lung. The pathophysiology of immune checkpoint inhibitor-induced scleroderma is not completely understood. A proposed mechanism is discussed along with the clinical presentation of symptoms and associated therapeutic response in cancer treatment. This case contributes to the few existing reports of immune checkpoint inhibitor-induced scleroderma to better understand the implications in the management of cutaneous immune-related adverse events. |
format | Online Article Text |
id | pubmed-9779987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-97799872022-12-23 Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung Dobrzynski, Jeffrey L. Vest, Blake E. Swick, Brian L. Case Rep Dermatol Med Case Report Immune checkpoint inhibitors are associated with a spectrum of cutaneous immune-related adverse events. While maculopapular eruptions are the most common cutaneous adverse event, scleroderma can rarely develop. Herein, we report a case of new-onset scleroderma associated with avelumab treatment in the setting of metastatic squamous cell carcinoma of the lung. The pathophysiology of immune checkpoint inhibitor-induced scleroderma is not completely understood. A proposed mechanism is discussed along with the clinical presentation of symptoms and associated therapeutic response in cancer treatment. This case contributes to the few existing reports of immune checkpoint inhibitor-induced scleroderma to better understand the implications in the management of cutaneous immune-related adverse events. Hindawi 2022-12-15 /pmc/articles/PMC9779987/ /pubmed/36567751 http://dx.doi.org/10.1155/2022/5360113 Text en Copyright © 2022 Jeffrey L. Dobrzynski et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Dobrzynski, Jeffrey L. Vest, Blake E. Swick, Brian L. Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung |
title | Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung |
title_full | Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung |
title_fullStr | Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung |
title_full_unstemmed | Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung |
title_short | Avelumab-Induced Scleroderma in a Patient with Metastatic Squamous Cell Carcinoma of the Lung |
title_sort | avelumab-induced scleroderma in a patient with metastatic squamous cell carcinoma of the lung |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9779987/ https://www.ncbi.nlm.nih.gov/pubmed/36567751 http://dx.doi.org/10.1155/2022/5360113 |
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