Celebrating 125 years of the synapse: from Sherrington to the present day

This themed collection celebrates 125 years of the synapse through a series of reviews written by a team of international experts in the field. The first in the series explains Sherrington’s contribution to the debate about the term ‘synapse’ and its function in neuronal signaling. The topics that follow cover recent developments in a wide range of topics: new technologies for research of synaptic structure; proteomics and the regulation of synaptic integrity and function; their role in the processing of information in thalamic neuronal circuits; and how genetic mutations can modify synaptic function in ways that can have profound effects on mood, cognition and behaviour.