3D genome organization

Our genomes are highly organized spatially in three-dimensions (3D). In interphase nuclei, the genome is anchored and regulated by various nuclear scaffolds and structures, including the nuclear lamina at the nuclear edge, and nucleoli located more internally within the nucleoplasm. Recently, great...

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Autores principales: Silahtaroglu, Asli, Bridger, Joanna M., Lei, Elissa P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780215/
https://www.ncbi.nlm.nih.gov/pubmed/36550272
http://dx.doi.org/10.1038/s41598-022-26725-7
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author Silahtaroglu, Asli
Bridger, Joanna M.
Lei, Elissa P.
author_facet Silahtaroglu, Asli
Bridger, Joanna M.
Lei, Elissa P.
author_sort Silahtaroglu, Asli
collection PubMed
description Our genomes are highly organized spatially in three-dimensions (3D). In interphase nuclei, the genome is anchored and regulated by various nuclear scaffolds and structures, including the nuclear lamina at the nuclear edge, and nucleoli located more internally within the nucleoplasm. Recently, great effort has been made to understand the intricacies of 3D genome organization and its relevance to genomic and nuclear function. Over the years, many concepts, mathematical models, visual and biochemical methods, and analysis pipelines have been presented to study various aspects of this organization in a multidisciplinary manner, such as is also reflected within this collection.
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spelling pubmed-97802152022-12-24 3D genome organization Silahtaroglu, Asli Bridger, Joanna M. Lei, Elissa P. Sci Rep Editorial Our genomes are highly organized spatially in three-dimensions (3D). In interphase nuclei, the genome is anchored and regulated by various nuclear scaffolds and structures, including the nuclear lamina at the nuclear edge, and nucleoli located more internally within the nucleoplasm. Recently, great effort has been made to understand the intricacies of 3D genome organization and its relevance to genomic and nuclear function. Over the years, many concepts, mathematical models, visual and biochemical methods, and analysis pipelines have been presented to study various aspects of this organization in a multidisciplinary manner, such as is also reflected within this collection. Nature Publishing Group UK 2022-12-22 /pmc/articles/PMC9780215/ /pubmed/36550272 http://dx.doi.org/10.1038/s41598-022-26725-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Editorial
Silahtaroglu, Asli
Bridger, Joanna M.
Lei, Elissa P.
3D genome organization
title 3D genome organization
title_full 3D genome organization
title_fullStr 3D genome organization
title_full_unstemmed 3D genome organization
title_short 3D genome organization
title_sort 3d genome organization
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780215/
https://www.ncbi.nlm.nih.gov/pubmed/36550272
http://dx.doi.org/10.1038/s41598-022-26725-7
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