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Postbiotics: The concept and their use in healthy populations

The term postbiotic was recently defined by an panel of scientists convened by the International Scientific Association of Probiotics and Prebiotics as “a preparation of inanimate microorganisms and/or their components that confers a health benefit on the host.” This definition focused on the progen...

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Autores principales: Vinderola, Gabriel, Sanders, Mary Ellen, Salminen, Seppo, Szajewska, Hania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780264/
https://www.ncbi.nlm.nih.gov/pubmed/36570166
http://dx.doi.org/10.3389/fnut.2022.1002213
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author Vinderola, Gabriel
Sanders, Mary Ellen
Salminen, Seppo
Szajewska, Hania
author_facet Vinderola, Gabriel
Sanders, Mary Ellen
Salminen, Seppo
Szajewska, Hania
author_sort Vinderola, Gabriel
collection PubMed
description The term postbiotic was recently defined by an panel of scientists convened by the International Scientific Association of Probiotics and Prebiotics as “a preparation of inanimate microorganisms and/or their components that confers a health benefit on the host.” This definition focused on the progenitor microbial cell or cell fragments, not just metabolites, proteins or carbohydrates they might produce. Although such microbe-produced constituents may be functional ingredients of the preparation, they are not required to be present in a postbiotic according to this definition. In this context, terms previously used such as paraprobiotics, ghostbiotics, heat-inactivated probiotics, non-viable probiotics, cell fragments or cell lysates, among others, align with the term postbiotics as conceived by this definition. The applications of postbiotics to infant nutrition and pediatric and adult gastroenterology, mainly, are under development. Some applications for skin health are also underway. As postbiotics are composed of inanimate microorganisms, they cannot colonize the host. However, they can in theory modify the composition or functions of the host microbiota, although evidence for this is scarce. Clinical results are promising, but, overall, there is limited evidence for postbiotics in healthy populations. For example, postbiotics have been studied in fermented infant formulas. The regulation of the term postbiotic is still in its infancy, as no government or international agency around the world has yet incorporated this term in their regulation.
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spelling pubmed-97802642022-12-24 Postbiotics: The concept and their use in healthy populations Vinderola, Gabriel Sanders, Mary Ellen Salminen, Seppo Szajewska, Hania Front Nutr Nutrition The term postbiotic was recently defined by an panel of scientists convened by the International Scientific Association of Probiotics and Prebiotics as “a preparation of inanimate microorganisms and/or their components that confers a health benefit on the host.” This definition focused on the progenitor microbial cell or cell fragments, not just metabolites, proteins or carbohydrates they might produce. Although such microbe-produced constituents may be functional ingredients of the preparation, they are not required to be present in a postbiotic according to this definition. In this context, terms previously used such as paraprobiotics, ghostbiotics, heat-inactivated probiotics, non-viable probiotics, cell fragments or cell lysates, among others, align with the term postbiotics as conceived by this definition. The applications of postbiotics to infant nutrition and pediatric and adult gastroenterology, mainly, are under development. Some applications for skin health are also underway. As postbiotics are composed of inanimate microorganisms, they cannot colonize the host. However, they can in theory modify the composition or functions of the host microbiota, although evidence for this is scarce. Clinical results are promising, but, overall, there is limited evidence for postbiotics in healthy populations. For example, postbiotics have been studied in fermented infant formulas. The regulation of the term postbiotic is still in its infancy, as no government or international agency around the world has yet incorporated this term in their regulation. Frontiers Media S.A. 2022-12-09 /pmc/articles/PMC9780264/ /pubmed/36570166 http://dx.doi.org/10.3389/fnut.2022.1002213 Text en Copyright © 2022 Vinderola, Sanders, Salminen and Szajewska. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Vinderola, Gabriel
Sanders, Mary Ellen
Salminen, Seppo
Szajewska, Hania
Postbiotics: The concept and their use in healthy populations
title Postbiotics: The concept and their use in healthy populations
title_full Postbiotics: The concept and their use in healthy populations
title_fullStr Postbiotics: The concept and their use in healthy populations
title_full_unstemmed Postbiotics: The concept and their use in healthy populations
title_short Postbiotics: The concept and their use in healthy populations
title_sort postbiotics: the concept and their use in healthy populations
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780264/
https://www.ncbi.nlm.nih.gov/pubmed/36570166
http://dx.doi.org/10.3389/fnut.2022.1002213
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