The impact of increasing levels of blood C-reactive protein on the inflammatory loci SPI1 and CD33 in Alzheimer’s disease

Apolipoprotein ε4 (APOE ε4) is the most significant genetic risk factor for late-onset Alzheimer’s disease (AD). Elevated blood C-reactive protein (CRP) further increases the risk of AD for people carrying the APOE ε4 allele. We hypothesized that CRP, as a key inflammatory element, could modulate th...

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Detalles Bibliográficos
Autores principales: Huang, Jinghan, Tao, Qiushan, Ang, Ting Fang Alvin, Farrell, John, Zhu, Congcong, Wang, Yixuan, Stein, Thor D., Lunetta, Kathryn L., Massaro, Joseph, Mez, Jesse, Au, Rhoda, Farrer, Lindsay A., Qiu, Wei Qiao, Zhang, Xiaoling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780312/
https://www.ncbi.nlm.nih.gov/pubmed/36550123
http://dx.doi.org/10.1038/s41398-022-02281-6

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