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A conformation-specific nanobody targeting the nicotinamide mononucleotide-activated state of SARM1

Sterile alpha (SAM) and Toll/interleukin-1 receptor (TIR) motif containing 1 (SARM1) is an autoinhibitory NAD-consuming enzyme that is activated by the accumulation of nicotinamide mononucleotide (NMN) during axonal injury. Its activation mechanism is not fully understood. Here, we generate a nanobo...

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Detalles Bibliográficos
Autores principales:	Hou, Yun Nan, Cai, Yang, Li, Wan Hua, He, Wei Ming, Zhao, Zhi Ying, Zhu, Wen Jie, Wang, Qiang, Mai, Xinyi, Liu, Jun, Lee, Hon Cheung, Stjepanovic, Goran, Zhang, Hongmin, Zhao, Yong Juan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780360/ https://www.ncbi.nlm.nih.gov/pubmed/36550129 http://dx.doi.org/10.1038/s41467-022-35581-y

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