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Risk factors of chronic kidney disease among type 2 diabetic patients with longer duration of diabetes

BACKGROUND: Chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM) is the major cause of end stage renal disease, characterized by proteinuria with a subsequent decline in glomerular filtration rate. Although hyperglycemia is the major risk factor for the development and progr...

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Autores principales: Siddiqui, Khalid, George, Teena P., Joy, Salini S., Alfadda, Assim A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780388/
https://www.ncbi.nlm.nih.gov/pubmed/36568108
http://dx.doi.org/10.3389/fendo.2022.1079725
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author Siddiqui, Khalid
George, Teena P.
Joy, Salini S.
Alfadda, Assim A.
author_facet Siddiqui, Khalid
George, Teena P.
Joy, Salini S.
Alfadda, Assim A.
author_sort Siddiqui, Khalid
collection PubMed
description BACKGROUND: Chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM) is the major cause of end stage renal disease, characterized by proteinuria with a subsequent decline in glomerular filtration rate. Although hyperglycemia is the major risk factor for the development and progression of kidney disease among diabetic patients, many other risk factors also contribute to structural and functional changes in the kidneys. As recommended by Kidney Disease Improving Global Outcomes (KDIGO), CKD classification based on cause and severity, links to risk of adverse outcomes including mortality and kidney outcomes. OBJECTIVE: The aim of this study is to investigate the involvement of risk factors associated with the severity of CKD among participants with longer duration of diabetes. This study also aims to find whether number of risk factors vary among risk of CKD progression categories based on KDIGO classification. MATERIAL AND METHODS: This cross-sectional study retrospectively selected 424 participants from type 2 diabetic cohort and categorized them based on the classifications for the diagnosis of kidney diseases in patients with diabetes, according to the KDIGO guidelines. Odds ratios and 95% CI of each risk factors according to severity of renal disease were determined. RESULTS: Based on KDIGO classification, participants with type 2 diabetes (T2D) were categorized in to low risk (n=174); moderately increased risk (n=98); and high/very high risk (n=152). Type 2 diabetic participants with risk factors such as, hyperlipidemia, hypertension, DM duration ≥15 years and diabetic retinopathy showed a high/very high risk of CKD progression when compared with low-risk category. While T2D participants with risk factors such as, lack of exercise, hypertension, and diabetic retinopathy showed a moderately increased risk of CKD progression. In addition, participants with highest number of risk factors were significantly distributed among high/very high risk of CKD progression category. CONCLUSION: This study findings conclude that patients with T2DM and duration of ≥15 years, hyperlipidemia, hypertension and diabetic retinopathy have an increased prevalence of advanced CKD. In addition to this, increased number of risk factors could be an indicator of the severity of CKD in T2D.
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spelling pubmed-97803882022-12-24 Risk factors of chronic kidney disease among type 2 diabetic patients with longer duration of diabetes Siddiqui, Khalid George, Teena P. Joy, Salini S. Alfadda, Assim A. Front Endocrinol (Lausanne) Endocrinology BACKGROUND: Chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM) is the major cause of end stage renal disease, characterized by proteinuria with a subsequent decline in glomerular filtration rate. Although hyperglycemia is the major risk factor for the development and progression of kidney disease among diabetic patients, many other risk factors also contribute to structural and functional changes in the kidneys. As recommended by Kidney Disease Improving Global Outcomes (KDIGO), CKD classification based on cause and severity, links to risk of adverse outcomes including mortality and kidney outcomes. OBJECTIVE: The aim of this study is to investigate the involvement of risk factors associated with the severity of CKD among participants with longer duration of diabetes. This study also aims to find whether number of risk factors vary among risk of CKD progression categories based on KDIGO classification. MATERIAL AND METHODS: This cross-sectional study retrospectively selected 424 participants from type 2 diabetic cohort and categorized them based on the classifications for the diagnosis of kidney diseases in patients with diabetes, according to the KDIGO guidelines. Odds ratios and 95% CI of each risk factors according to severity of renal disease were determined. RESULTS: Based on KDIGO classification, participants with type 2 diabetes (T2D) were categorized in to low risk (n=174); moderately increased risk (n=98); and high/very high risk (n=152). Type 2 diabetic participants with risk factors such as, hyperlipidemia, hypertension, DM duration ≥15 years and diabetic retinopathy showed a high/very high risk of CKD progression when compared with low-risk category. While T2D participants with risk factors such as, lack of exercise, hypertension, and diabetic retinopathy showed a moderately increased risk of CKD progression. In addition, participants with highest number of risk factors were significantly distributed among high/very high risk of CKD progression category. CONCLUSION: This study findings conclude that patients with T2DM and duration of ≥15 years, hyperlipidemia, hypertension and diabetic retinopathy have an increased prevalence of advanced CKD. In addition to this, increased number of risk factors could be an indicator of the severity of CKD in T2D. Frontiers Media S.A. 2022-12-09 /pmc/articles/PMC9780388/ /pubmed/36568108 http://dx.doi.org/10.3389/fendo.2022.1079725 Text en Copyright © 2022 Siddiqui, George, Joy and Alfadda https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Siddiqui, Khalid
George, Teena P.
Joy, Salini S.
Alfadda, Assim A.
Risk factors of chronic kidney disease among type 2 diabetic patients with longer duration of diabetes
title Risk factors of chronic kidney disease among type 2 diabetic patients with longer duration of diabetes
title_full Risk factors of chronic kidney disease among type 2 diabetic patients with longer duration of diabetes
title_fullStr Risk factors of chronic kidney disease among type 2 diabetic patients with longer duration of diabetes
title_full_unstemmed Risk factors of chronic kidney disease among type 2 diabetic patients with longer duration of diabetes
title_short Risk factors of chronic kidney disease among type 2 diabetic patients with longer duration of diabetes
title_sort risk factors of chronic kidney disease among type 2 diabetic patients with longer duration of diabetes
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780388/
https://www.ncbi.nlm.nih.gov/pubmed/36568108
http://dx.doi.org/10.3389/fendo.2022.1079725
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