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A pilot study on the efficacy of topical lotion containing anti-acne postbiotic in subjects with mild -to -moderate acne
INTRODUCTION: Acne can compromise facial esthetics and become a mental burden, especially when it occurs in puberty. Skincare cosmetics with anti-acne efficiency is more convenient than other treatment modalities, such as dietary supplements, in certain circumstances. The purpose of this study was t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780477/ https://www.ncbi.nlm.nih.gov/pubmed/36569166 http://dx.doi.org/10.3389/fmed.2022.1064460 |
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author | Cui, Hongchang Guo, Chaoqun Wang, Qian Feng, Congrui Duan, Zhi |
author_facet | Cui, Hongchang Guo, Chaoqun Wang, Qian Feng, Congrui Duan, Zhi |
author_sort | Cui, Hongchang |
collection | PubMed |
description | INTRODUCTION: Acne can compromise facial esthetics and become a mental burden, especially when it occurs in puberty. Skincare cosmetics with anti-acne efficiency is more convenient than other treatment modalities, such as dietary supplements, in certain circumstances. The purpose of this study was to investigate the efficacy of an anti-acne lotion in alleviating acne. METHODS: In our study, an anti-acne lotion containing ferment lysate produced by Lactiplantibacillus plantarum VHProbi(®) E15 were applied to subjects with mild -to -moderate acne over 4 weeks. The efficacy was evaluated based on instrumental measurements using Visia(®)-CR and CK-MPA(®) system. RESULTS AND DISCUSSION: The anti-acne lotion exhibited favorable safety, meeting the stringent criteria for the detection of microbes, heavy metals, toxicity, and irritation. After 2 weeks of treatment, a statistically significant improvement in acne lesions was observed compared to baseline (P < 0.01), and this continued to the end of the study. After 4 weeks of treatment, the transepidermal water loss (P < 0.05) and sebum production (P < 0.05) were significantly decreased in subjects compared to baseline. In addition, the pore/area of interest (AOI) and stratum corneum hydration displayed slightly positive changes throughout treatment. Thus, we conclude that applying topical anti-acne lotion may be safe and confer effective benefits in people with mild -to -moderate acne and represents a promising therapeutic option for acne. |
format | Online Article Text |
id | pubmed-9780477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97804772022-12-24 A pilot study on the efficacy of topical lotion containing anti-acne postbiotic in subjects with mild -to -moderate acne Cui, Hongchang Guo, Chaoqun Wang, Qian Feng, Congrui Duan, Zhi Front Med (Lausanne) Medicine INTRODUCTION: Acne can compromise facial esthetics and become a mental burden, especially when it occurs in puberty. Skincare cosmetics with anti-acne efficiency is more convenient than other treatment modalities, such as dietary supplements, in certain circumstances. The purpose of this study was to investigate the efficacy of an anti-acne lotion in alleviating acne. METHODS: In our study, an anti-acne lotion containing ferment lysate produced by Lactiplantibacillus plantarum VHProbi(®) E15 were applied to subjects with mild -to -moderate acne over 4 weeks. The efficacy was evaluated based on instrumental measurements using Visia(®)-CR and CK-MPA(®) system. RESULTS AND DISCUSSION: The anti-acne lotion exhibited favorable safety, meeting the stringent criteria for the detection of microbes, heavy metals, toxicity, and irritation. After 2 weeks of treatment, a statistically significant improvement in acne lesions was observed compared to baseline (P < 0.01), and this continued to the end of the study. After 4 weeks of treatment, the transepidermal water loss (P < 0.05) and sebum production (P < 0.05) were significantly decreased in subjects compared to baseline. In addition, the pore/area of interest (AOI) and stratum corneum hydration displayed slightly positive changes throughout treatment. Thus, we conclude that applying topical anti-acne lotion may be safe and confer effective benefits in people with mild -to -moderate acne and represents a promising therapeutic option for acne. Frontiers Media S.A. 2022-12-09 /pmc/articles/PMC9780477/ /pubmed/36569166 http://dx.doi.org/10.3389/fmed.2022.1064460 Text en Copyright © 2022 Cui, Guo, Wang, Feng and Duan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Cui, Hongchang Guo, Chaoqun Wang, Qian Feng, Congrui Duan, Zhi A pilot study on the efficacy of topical lotion containing anti-acne postbiotic in subjects with mild -to -moderate acne |
title | A pilot study on the efficacy of topical lotion containing anti-acne postbiotic in subjects with mild -to -moderate acne |
title_full | A pilot study on the efficacy of topical lotion containing anti-acne postbiotic in subjects with mild -to -moderate acne |
title_fullStr | A pilot study on the efficacy of topical lotion containing anti-acne postbiotic in subjects with mild -to -moderate acne |
title_full_unstemmed | A pilot study on the efficacy of topical lotion containing anti-acne postbiotic in subjects with mild -to -moderate acne |
title_short | A pilot study on the efficacy of topical lotion containing anti-acne postbiotic in subjects with mild -to -moderate acne |
title_sort | pilot study on the efficacy of topical lotion containing anti-acne postbiotic in subjects with mild -to -moderate acne |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780477/ https://www.ncbi.nlm.nih.gov/pubmed/36569166 http://dx.doi.org/10.3389/fmed.2022.1064460 |
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