Cytomegalovirus reactivation in a SARS-CoV-2 infected woman experiencing fetal demise in the first trimester with fetal trisomy 21: A case report

Cytomegalovirus (CMV) is the most common cause of congenital viral infections. Women seropositive for CMV prior to pregnancy can develop a non-primary CMV infection. Here, we present a case of first trimester pregnancy loss during active SARS-CoV-2 infection. There was no evidence of SARS-CoV-2 RNA...

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Detalles Bibliográficos
Autores principales: Pande, Shailesh, Gandhewar, Manisha, Gaikwad, Pradeep, Shende, Prajakta, Munne, Kiran, Bhor, Vikrant M., Das, Dhanjit, Bashani, Dolly, Bhase, Manasi, Rathore, Amisha, Shah, Karan, Gawde, Harshavardhan, Padwal, Varsha, Bhagat, Sharad, Menon, Shyla, Palav, Harsha, Sachdeva, Geetanjali, Patel, Vainav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Indian Association of Medical Microbiologists. Published by Elsevier B.V. 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780583/
https://www.ncbi.nlm.nih.gov/pubmed/36870740
http://dx.doi.org/10.1016/j.ijmmb.2022.12.002
Descripción
Sumario:Cytomegalovirus (CMV) is the most common cause of congenital viral infections. Women seropositive for CMV prior to pregnancy can develop a non-primary CMV infection. Here, we present a case of first trimester pregnancy loss during active SARS-CoV-2 infection. There was no evidence of SARS-CoV-2 RNA in placenta and fetal tissue, but there was presence of congenital cytomegalovirus infection by nested PCR. To the best of our knowledge, this is the first report demonstrating association of early congenital CMV infection due to reactivation and fetal demise in a SARS-CoV-2 positive woman with fetal trisomy 21.

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