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Profiling of Urinary Glucuronidated Bile Acids across Age Groups
We investigated the age-dependent changes in urinary excretion of glucuronidated bile acids at the C-3 position. Bile acid 3-glucuronides accounted for 0.5% of urinary bile acids in neonates, and the proportion of bile acid 3-glucuronides plateaued at 1–3 years of age. The 3-glucuronides of secondar...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780789/ https://www.ncbi.nlm.nih.gov/pubmed/36557268 http://dx.doi.org/10.3390/metabo12121230 |
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author | Muto, Yamato Suzuki, Mitsuyoshi Kakiyama, Genta Sasaki, Takahiro Murai, Tsuyoshi Takei, Hajime Nittono, Hiroshi |
author_facet | Muto, Yamato Suzuki, Mitsuyoshi Kakiyama, Genta Sasaki, Takahiro Murai, Tsuyoshi Takei, Hajime Nittono, Hiroshi |
author_sort | Muto, Yamato |
collection | PubMed |
description | We investigated the age-dependent changes in urinary excretion of glucuronidated bile acids at the C-3 position. Bile acid 3-glucuronides accounted for 0.5% of urinary bile acids in neonates, and the proportion of bile acid 3-glucuronides plateaued at 1–3 years of age. The 3-glucuronides of secondary bile acids were first secreted at 3 months of age, the same time as the establishment of the gut bacterial flora in infants. A considerable portion of bile acid 3-glucuronides were present as non-amidated forms. Our results indicate dynamic hepatic enzyme activity in which the levels of uridine 5′-diphospho-glucuronosyltransferases (UGTs) differ by age group, with higher glucuronidation activity of UGTs towards nonamidated bile acids than amidated bile acids. |
format | Online Article Text |
id | pubmed-9780789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97807892022-12-24 Profiling of Urinary Glucuronidated Bile Acids across Age Groups Muto, Yamato Suzuki, Mitsuyoshi Kakiyama, Genta Sasaki, Takahiro Murai, Tsuyoshi Takei, Hajime Nittono, Hiroshi Metabolites Brief Report We investigated the age-dependent changes in urinary excretion of glucuronidated bile acids at the C-3 position. Bile acid 3-glucuronides accounted for 0.5% of urinary bile acids in neonates, and the proportion of bile acid 3-glucuronides plateaued at 1–3 years of age. The 3-glucuronides of secondary bile acids were first secreted at 3 months of age, the same time as the establishment of the gut bacterial flora in infants. A considerable portion of bile acid 3-glucuronides were present as non-amidated forms. Our results indicate dynamic hepatic enzyme activity in which the levels of uridine 5′-diphospho-glucuronosyltransferases (UGTs) differ by age group, with higher glucuronidation activity of UGTs towards nonamidated bile acids than amidated bile acids. MDPI 2022-12-07 /pmc/articles/PMC9780789/ /pubmed/36557268 http://dx.doi.org/10.3390/metabo12121230 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Muto, Yamato Suzuki, Mitsuyoshi Kakiyama, Genta Sasaki, Takahiro Murai, Tsuyoshi Takei, Hajime Nittono, Hiroshi Profiling of Urinary Glucuronidated Bile Acids across Age Groups |
title | Profiling of Urinary Glucuronidated Bile Acids across Age Groups |
title_full | Profiling of Urinary Glucuronidated Bile Acids across Age Groups |
title_fullStr | Profiling of Urinary Glucuronidated Bile Acids across Age Groups |
title_full_unstemmed | Profiling of Urinary Glucuronidated Bile Acids across Age Groups |
title_short | Profiling of Urinary Glucuronidated Bile Acids across Age Groups |
title_sort | profiling of urinary glucuronidated bile acids across age groups |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780789/ https://www.ncbi.nlm.nih.gov/pubmed/36557268 http://dx.doi.org/10.3390/metabo12121230 |
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