Determination of the Pharmacokinetics and Pharmacodynamics of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol in a Cross-Over Cynomolgus Macaque Model of Mycobacterium tuberculosis Infection

Innovative cross-over study designs were explored in non-human primate (NHP) studies to determine the value of this approach for the evaluation of drug efficacy against tuberculosis (TB). Firstly, the pharmacokinetics (PK) of each of the drugs Isoniazid (H), Rifampicin (R), Pyrazinamide (Z) and Etha...

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Detalles Bibliográficos
Autores principales: Sibley, Laura, White, Andrew D., Sarfas, Charlotte, Gullick, Jennie, Gleeson, Fergus, Lanni, Faye, Clark, Simon, Rayner, Emma, Ferrer-Bazaga, Santiago, Ortega-Muro, Fatima, Alameda, Laura, Rullas, Joaquin, Sousa, Veronica, Martinez, Marisa, Angulo-Barturen, Inigo, Garcia, Adolfo, Vaquero, Juan José, Pertinez, Henry E., Davies, Geraint, Dennis, Mike, Williams, Ann, Sharpe, Sally
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780811/
https://www.ncbi.nlm.nih.gov/pubmed/36559163
http://dx.doi.org/10.3390/pharmaceutics14122666

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780811/
https://www.ncbi.nlm.nih.gov/pubmed/36559163
http://dx.doi.org/10.3390/pharmaceutics14122666

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