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Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor
Traditional hydrogels have drawbacks such as surgical implantation, large wound surfaces, and uncontrollable drug release during tumor treatment. In this paper, targeted nanomedicine has been combined with injectable hydrogel for photothermal–chemotherapy combination therapy. First, targeted nanomed...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780840/ https://www.ncbi.nlm.nih.gov/pubmed/36559914 http://dx.doi.org/10.3390/polym14245547 |
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author | Qi, Dashan Zhu, Haowei Kong, Yingjie Shen, Qingming |
author_facet | Qi, Dashan Zhu, Haowei Kong, Yingjie Shen, Qingming |
author_sort | Qi, Dashan |
collection | PubMed |
description | Traditional hydrogels have drawbacks such as surgical implantation, large wound surfaces, and uncontrollable drug release during tumor treatment. In this paper, targeted nanomedicine has been combined with injectable hydrogel for photothermal–chemotherapy combination therapy. First, targeted nanomedicine (ICG—MTX) was fabricated by combining near-infrared (NIR) photothermal reagents (ICG) and chemotherapy drugs (MTX). The ICG—MTX was then mixed with the hydrogel precursor and radical initiator to obtain an injectable hydrogel precursor solution. Under the irradiation of NIR light, the precursor solution could release alkyl radicals, which promote the transition of the precursor solution from a liquid to a colloidal state. As a result, the nanomedicine could effectively remain at the site of the tumor and continue to be released from the hydrogel. Due to the targeted nature of MTX, the released ICG—MTX could target tumor cells and improve the accuracy of photothermal–chemo combination therapy. The results indicated that the injectable nanomedicine–hydrogel system has a favorable therapeutic effect on tumors. |
format | Online Article Text |
id | pubmed-9780840 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97808402022-12-24 Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor Qi, Dashan Zhu, Haowei Kong, Yingjie Shen, Qingming Polymers (Basel) Article Traditional hydrogels have drawbacks such as surgical implantation, large wound surfaces, and uncontrollable drug release during tumor treatment. In this paper, targeted nanomedicine has been combined with injectable hydrogel for photothermal–chemotherapy combination therapy. First, targeted nanomedicine (ICG—MTX) was fabricated by combining near-infrared (NIR) photothermal reagents (ICG) and chemotherapy drugs (MTX). The ICG—MTX was then mixed with the hydrogel precursor and radical initiator to obtain an injectable hydrogel precursor solution. Under the irradiation of NIR light, the precursor solution could release alkyl radicals, which promote the transition of the precursor solution from a liquid to a colloidal state. As a result, the nanomedicine could effectively remain at the site of the tumor and continue to be released from the hydrogel. Due to the targeted nature of MTX, the released ICG—MTX could target tumor cells and improve the accuracy of photothermal–chemo combination therapy. The results indicated that the injectable nanomedicine–hydrogel system has a favorable therapeutic effect on tumors. MDPI 2022-12-18 /pmc/articles/PMC9780840/ /pubmed/36559914 http://dx.doi.org/10.3390/polym14245547 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Qi, Dashan Zhu, Haowei Kong, Yingjie Shen, Qingming Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor |
title | Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor |
title_full | Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor |
title_fullStr | Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor |
title_full_unstemmed | Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor |
title_short | Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor |
title_sort | injectable nanomedicine–hydrogel for nir light photothermal–chemo combination therapy of tumor |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780840/ https://www.ncbi.nlm.nih.gov/pubmed/36559914 http://dx.doi.org/10.3390/polym14245547 |
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