Cargando…

Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor

Traditional hydrogels have drawbacks such as surgical implantation, large wound surfaces, and uncontrollable drug release during tumor treatment. In this paper, targeted nanomedicine has been combined with injectable hydrogel for photothermal–chemotherapy combination therapy. First, targeted nanomed...

Descripción completa

Detalles Bibliográficos
Autores principales: Qi, Dashan, Zhu, Haowei, Kong, Yingjie, Shen, Qingming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780840/
https://www.ncbi.nlm.nih.gov/pubmed/36559914
http://dx.doi.org/10.3390/polym14245547
_version_ 1784856927627378688
author Qi, Dashan
Zhu, Haowei
Kong, Yingjie
Shen, Qingming
author_facet Qi, Dashan
Zhu, Haowei
Kong, Yingjie
Shen, Qingming
author_sort Qi, Dashan
collection PubMed
description Traditional hydrogels have drawbacks such as surgical implantation, large wound surfaces, and uncontrollable drug release during tumor treatment. In this paper, targeted nanomedicine has been combined with injectable hydrogel for photothermal–chemotherapy combination therapy. First, targeted nanomedicine (ICG—MTX) was fabricated by combining near-infrared (NIR) photothermal reagents (ICG) and chemotherapy drugs (MTX). The ICG—MTX was then mixed with the hydrogel precursor and radical initiator to obtain an injectable hydrogel precursor solution. Under the irradiation of NIR light, the precursor solution could release alkyl radicals, which promote the transition of the precursor solution from a liquid to a colloidal state. As a result, the nanomedicine could effectively remain at the site of the tumor and continue to be released from the hydrogel. Due to the targeted nature of MTX, the released ICG—MTX could target tumor cells and improve the accuracy of photothermal–chemo combination therapy. The results indicated that the injectable nanomedicine–hydrogel system has a favorable therapeutic effect on tumors.
format Online
Article
Text
id pubmed-9780840
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97808402022-12-24 Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor Qi, Dashan Zhu, Haowei Kong, Yingjie Shen, Qingming Polymers (Basel) Article Traditional hydrogels have drawbacks such as surgical implantation, large wound surfaces, and uncontrollable drug release during tumor treatment. In this paper, targeted nanomedicine has been combined with injectable hydrogel for photothermal–chemotherapy combination therapy. First, targeted nanomedicine (ICG—MTX) was fabricated by combining near-infrared (NIR) photothermal reagents (ICG) and chemotherapy drugs (MTX). The ICG—MTX was then mixed with the hydrogel precursor and radical initiator to obtain an injectable hydrogel precursor solution. Under the irradiation of NIR light, the precursor solution could release alkyl radicals, which promote the transition of the precursor solution from a liquid to a colloidal state. As a result, the nanomedicine could effectively remain at the site of the tumor and continue to be released from the hydrogel. Due to the targeted nature of MTX, the released ICG—MTX could target tumor cells and improve the accuracy of photothermal–chemo combination therapy. The results indicated that the injectable nanomedicine–hydrogel system has a favorable therapeutic effect on tumors. MDPI 2022-12-18 /pmc/articles/PMC9780840/ /pubmed/36559914 http://dx.doi.org/10.3390/polym14245547 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Qi, Dashan
Zhu, Haowei
Kong, Yingjie
Shen, Qingming
Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor
title Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor
title_full Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor
title_fullStr Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor
title_full_unstemmed Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor
title_short Injectable Nanomedicine–Hydrogel for NIR Light Photothermal–Chemo Combination Therapy of Tumor
title_sort injectable nanomedicine–hydrogel for nir light photothermal–chemo combination therapy of tumor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780840/
https://www.ncbi.nlm.nih.gov/pubmed/36559914
http://dx.doi.org/10.3390/polym14245547
work_keys_str_mv AT qidashan injectablenanomedicinehydrogelfornirlightphotothermalchemocombinationtherapyoftumor
AT zhuhaowei injectablenanomedicinehydrogelfornirlightphotothermalchemocombinationtherapyoftumor
AT kongyingjie injectablenanomedicinehydrogelfornirlightphotothermalchemocombinationtherapyoftumor
AT shenqingming injectablenanomedicinehydrogelfornirlightphotothermalchemocombinationtherapyoftumor