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COVID-19 and NSTEMI Outcomes among Hospitalized Patients in the United States and Racial Disparities in Mortality: Insight from National Inpatient Sample Database

The COVID-19 pandemic has impacted healthcare delivery to patients with non-ST-segment elevation myocardial infraction (NSTEMI). The aim of our retrospective study is to determine the effect of COVID-19 on inpatient NSTEMI outcomes and to investigate whether changes in cardiac care contributed to th...

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Autores principales: Majeed, Harris, Gangu, Karthik, Sagheer, Shazib, Garg, Ishan, Khan, Umair, Shuja, Hina, Bobba, Aniesh, Chourasia, Prabal, Shekhar, Rahul, Avula, Sindhu Reddy, Sheikh, Abu Baker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780864/
https://www.ncbi.nlm.nih.gov/pubmed/36560434
http://dx.doi.org/10.3390/vaccines10122024
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author Majeed, Harris
Gangu, Karthik
Sagheer, Shazib
Garg, Ishan
Khan, Umair
Shuja, Hina
Bobba, Aniesh
Chourasia, Prabal
Shekhar, Rahul
Avula, Sindhu Reddy
Sheikh, Abu Baker
author_facet Majeed, Harris
Gangu, Karthik
Sagheer, Shazib
Garg, Ishan
Khan, Umair
Shuja, Hina
Bobba, Aniesh
Chourasia, Prabal
Shekhar, Rahul
Avula, Sindhu Reddy
Sheikh, Abu Baker
author_sort Majeed, Harris
collection PubMed
description The COVID-19 pandemic has impacted healthcare delivery to patients with non-ST-segment elevation myocardial infraction (NSTEMI). The aim of our retrospective study is to determine the effect of COVID-19 on inpatient NSTEMI outcomes and to investigate whether changes in cardiac care contributed to the observed outcomes. After multivariate adjustment, we found that NSTEMI patients with COVID-19 had a higher rate of inpatient mortality (37.3% vs. 7.3%, adjusted odds ratio: 4.96, 95% CI: 4.6–5.4, p < 0.001), increased length of stay (9.9 days vs. 5.4 days, adjusted LOS: 3.6 days longer, p < 0.001), and a higher cost of hospitalization (150,000 USD vs. 110,000 USD, inflation-adjusted cost of hospitalization: 36,000 USD higher, p < 0.001) in comparison to NSTEMI patients without COVID-19, despite a lower burden of pre-existing cardiac comorbidity. NSTEMI patients with COVID-19 also received less invasive cardiac procedures (coronary angiography: 8.7% vs. 50.3%, p < 0.001; PCI: 4.8% vs. 29%, p < 0.001; and CABG: 0.7% vs. 6.2%, p < 0.001). In our study, we observed increased mortality and in-hospital complications to be a combined effect of COVID-19 infection and myocardial inflammation as a result of cytokine storm, prothrombic state, oxygen supply/demand imbalance and alterations in healthcare delivery from January to December 2020.
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spelling pubmed-97808642022-12-24 COVID-19 and NSTEMI Outcomes among Hospitalized Patients in the United States and Racial Disparities in Mortality: Insight from National Inpatient Sample Database Majeed, Harris Gangu, Karthik Sagheer, Shazib Garg, Ishan Khan, Umair Shuja, Hina Bobba, Aniesh Chourasia, Prabal Shekhar, Rahul Avula, Sindhu Reddy Sheikh, Abu Baker Vaccines (Basel) Review The COVID-19 pandemic has impacted healthcare delivery to patients with non-ST-segment elevation myocardial infraction (NSTEMI). The aim of our retrospective study is to determine the effect of COVID-19 on inpatient NSTEMI outcomes and to investigate whether changes in cardiac care contributed to the observed outcomes. After multivariate adjustment, we found that NSTEMI patients with COVID-19 had a higher rate of inpatient mortality (37.3% vs. 7.3%, adjusted odds ratio: 4.96, 95% CI: 4.6–5.4, p < 0.001), increased length of stay (9.9 days vs. 5.4 days, adjusted LOS: 3.6 days longer, p < 0.001), and a higher cost of hospitalization (150,000 USD vs. 110,000 USD, inflation-adjusted cost of hospitalization: 36,000 USD higher, p < 0.001) in comparison to NSTEMI patients without COVID-19, despite a lower burden of pre-existing cardiac comorbidity. NSTEMI patients with COVID-19 also received less invasive cardiac procedures (coronary angiography: 8.7% vs. 50.3%, p < 0.001; PCI: 4.8% vs. 29%, p < 0.001; and CABG: 0.7% vs. 6.2%, p < 0.001). In our study, we observed increased mortality and in-hospital complications to be a combined effect of COVID-19 infection and myocardial inflammation as a result of cytokine storm, prothrombic state, oxygen supply/demand imbalance and alterations in healthcare delivery from January to December 2020. MDPI 2022-11-26 /pmc/articles/PMC9780864/ /pubmed/36560434 http://dx.doi.org/10.3390/vaccines10122024 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Majeed, Harris
Gangu, Karthik
Sagheer, Shazib
Garg, Ishan
Khan, Umair
Shuja, Hina
Bobba, Aniesh
Chourasia, Prabal
Shekhar, Rahul
Avula, Sindhu Reddy
Sheikh, Abu Baker
COVID-19 and NSTEMI Outcomes among Hospitalized Patients in the United States and Racial Disparities in Mortality: Insight from National Inpatient Sample Database
title COVID-19 and NSTEMI Outcomes among Hospitalized Patients in the United States and Racial Disparities in Mortality: Insight from National Inpatient Sample Database
title_full COVID-19 and NSTEMI Outcomes among Hospitalized Patients in the United States and Racial Disparities in Mortality: Insight from National Inpatient Sample Database
title_fullStr COVID-19 and NSTEMI Outcomes among Hospitalized Patients in the United States and Racial Disparities in Mortality: Insight from National Inpatient Sample Database
title_full_unstemmed COVID-19 and NSTEMI Outcomes among Hospitalized Patients in the United States and Racial Disparities in Mortality: Insight from National Inpatient Sample Database
title_short COVID-19 and NSTEMI Outcomes among Hospitalized Patients in the United States and Racial Disparities in Mortality: Insight from National Inpatient Sample Database
title_sort covid-19 and nstemi outcomes among hospitalized patients in the united states and racial disparities in mortality: insight from national inpatient sample database
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780864/
https://www.ncbi.nlm.nih.gov/pubmed/36560434
http://dx.doi.org/10.3390/vaccines10122024
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