Cargando…

Recent Advancement in Drug Design and Discovery of Pyrazole Biomolecules as Cancer and Inflammation Therapeutics

Pyrazole, an important pharmacophore and a privileged scaffold of immense significance, is a five-membered heterocyclic moiety with an extensive therapeutic profile, viz., anti-inflammatory, anti-microbial, anti-anxiety, anticancer, analgesic, antipyretic, etc. Due to the expansion of pyrazolecent r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alam, Md. Jahangir, Alam, Ozair, Naim, Mohd. Javed, Nawaz, Farah, Manaithiya, Ajay, Imran, Mohd, Thabet, Hamdy Khamees, Alshehri, Sultan, Ghoneim, Mohammed M., Alam, Prawez, Shakeel, Faiyaz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780894/ https://www.ncbi.nlm.nih.gov/pubmed/36557840 http://dx.doi.org/10.3390/molecules27248708

Ejemplares similares

Design, Synthesis, Molecular Docking, and Biological Evaluation of Pyrazole Hybrid Chalcone Conjugates as Potential Anticancer Agents and Tubulin Polymerization Inhibitors
por: Alam, Md. Jahangir, et al.
Publicado: (2022)

Current status of pyrazole and its biological activities
por: Naim, Mohd Javed, et al.
Publicado: (2016)

Insight into Structure Activity Relationship of DPP-4 Inhibitors for Development of Antidiabetic Agents
por: Mathur, Vishal, et al.
Publicado: (2023)

Synthesis, anti-inflammatory, analgesic, COX1/2-inhibitory activity, and molecular docking studies of hybrid pyrazole analogues
por: Alam, Md Jahangir, et al.
Publicado: (2016)

A Green High-Performance Thin-Layer Chromatography Method for the Determination of Caffeine in Commercial Energy Drinks and Formulations
por: Foudah, Ahmed I., et al.
Publicado: (2022)

Determination of Thymol in Commercial Formulation, Essential Oils, Traditional, and Ultrasound-Based Extracts of Thymus vulgaris and Origanum vulgare Using a Greener HPTLC Approach
por: Foudah, Ahmed I., et al.
Publicado: (2022)

Developing Nanosuspension Loaded with Azelastine for Potential Nasal Drug Delivery: Determination of Proinflammatory Interleukin IL-4 mRNA Expression and Industrial Scale-Up Strategy
por: Mehmood, Yasir, et al.
Publicado: (2023)

Investigating Antiarthritic Potential of Nanostructured Clove Oil (Syzygium aromaticum) in FCA-Induced Arthritic Rats: Pharmaceutical Action and Delivery Strategies
por: Shakeel, Faiyaz, et al.
Publicado: (2021)

Tricyclodecan-9-yl-Xanthogenate (D609): Mechanism of Action and Pharmacological Applications
por: Bhat, Aashiq Hussain, et al.
Publicado: (2022)

A Greener Stability-Indicating High-Performance Thin-Layer Chromatography Approach for the Estimation of Topiramate
por: Alqarni, Mohammed H., et al.
Publicado: (2022)

Discovery, Development, Inventions and Patent Review of Fexinidazole: The First All-Oral Therapy for Human African Trypanosomiasis
por: Imran, Mohd, et al.
Publicado: (2022)

Simultaneous Estimation of Escitalopram and Clonazepam in Tablet Dosage Forms Using HPLC-DAD Method and Optimization of Chromatographic Conditions by Box-Behnken Design
por: Foudah, Ahmed I., et al.
Publicado: (2022)

Hepatoprotective Effects of Bioflavonoid Luteolin Using Self-Nanoemulsifying Drug Delivery System
por: Shakeel, Faiyaz, et al.
Publicado: (2021)

Promising Role of Silk-Based Biomaterials for Ocular-Based Drug Delivery and Tissue Engineering
por: Wani, Shahid Ud Din, et al.
Publicado: (2022)

Utilization of Artificial Intelligence in Disease Prevention: Diagnosis, Treatment, and Implications for the Healthcare Workforce
por: Wani, Shahid Ud Din, et al.
Publicado: (2022)

Discovery, Development, Inventions, and Patent Trends on Mobocertinib Succinate: The First-in-Class Oral Treatment for NSCLC with EGFR Exon 20 Insertions
por: Imran, Mohd, et al.
Publicado: (2021)

Central Composite Design (CCD) for the Optimisation of Ethosomal Gel Formulation of Punica granatum Extract: In Vitro and In Vivo Evaluations
por: Alam, Prawez, et al.
Publicado: (2022)

A Review on the Main Phytoconstituents, Traditional Uses, Inventions, and Patent Literature of Gum Arabic Emphasizing Acacia seyal
por: Ashour, Mohamed A., et al.
Publicado: (2022)

Simultaneous Determination of Caffeine and Paracetamol in Commercial Formulations Using Greener Normal-Phase and Reversed-Phase HPTLC Methods: A Contrast of Validation Parameters
por: Alam, Prawez, et al.
Publicado: (2022)

Determination of Colchicine in Pharmaceutical Formulations, Traditional Extracts, and Ultrasonication-Based Extracts of Colchicum autumnale Pleniflorum (L.) Using Regular and Greener HPTLC Approaches: A Comparative Evaluation of Validation Parameters
por: Alqarni, Mohammed H., et al.
Publicado: (2022)

Quantitative Analysis of Emtricitabine in Dosage Forms Using Green RP-HPTLC and Routine NP-HPTLC Methods—A Contrast of Validation Parameters
por: Alam, Prawez, et al.
Publicado: (2020)

Solubility of Cinnarizine in (Transcutol + Water) Mixtures: Determination, Hansen Solubility Parameters, Correlation, and Thermodynamics
por: Shakeel, Faiyaz, et al.
Publicado: (2021)

Eco-Friendly High-Performance Thin-Layer Chromatography Method for the Determination of Tenoxicam in Commercial Formulations
por: Shakeel, Faiyaz, et al.
Publicado: (2023)

Silk Fibroin as an Efficient Biomaterial for Drug Delivery, Gene Therapy, and Wound Healing
por: Wani, Shahid Ud Din, et al.
Publicado: (2022)

Phytochemical Profiling and Antibacterial Activity of Methanol Leaf Extract of Skimmia anquetilia
por: Nabi, Masarat, et al.
Publicado: (2022)

Quantification of Pomalidomide Using Conventional and Eco-Friendly Stability-Indicating HPTLC Assays: A Contrast of Validation Parameters
por: Alam, Prawez, et al.
Publicado: (2023)

Quantification of Suvorexant in Human Urine Using a Validated HPTLC Bioanalytical Method
por: Alqarni, Mohammed H., et al.
Publicado: (2023)

Solubilization of Trans-Resveratrol in Some Mono-Solvents and Various Propylene Glycol + Water Mixtures
por: Ghazwani, Mohammed, et al.
Publicado: (2021)

Optimisation of a Greener-Approach for the Synthesis of Cyclodextrin-Based Nanosponges for the Solubility Enhancement of Domperidone, a BCS Class II Drug
por: Vij, Mohit, et al.
Publicado: (2023)

Simultaneous Determination of 6-Shogaol and 6-Gingerol in Various Ginger (Zingiber officinale Roscoe) Extracts and Commercial Formulations Using a Green RP-HPTLC-Densitometry Method
por: Foudah, Ahmed I., et al.
Publicado: (2020)

Combining Normal/Reversed-Phase HPTLC with Univariate Calibration for the Piperine Quantification with Traditional and Ultrasound-Assisted Extracts of Various Food Spices of Piper nigrum L. under Green Analytical Chemistry Viewpoint
por: Alqarni, Mohammed H., et al.
Publicado: (2021)

Synthesis, Characterization and Solubility Determination of 6-Phenyl-pyridazin-3(2H)-one in Different Pharmaceutical Solvents
por: Shakeel, Faiyaz, et al.
Publicado: (2019)

Newfangled Topical Film-Forming Solution for Facilitated Antifungal Therapy: Design, Development, Characterization, and In Vitro Evaluation
por: Dhimmar, Bhakti, et al.
Publicado: (2023)

Solubility Determination, Hansen Solubility Parameters and Thermodynamic Evaluation of Thymoquinone in (Isopropanol + Water) Compositions
por: Ghazwani, Mohammed, et al.
Publicado: (2021)

A Rapid and Sensitive Stability-Indicating Eco-Friendly HPTLC Assay for Fluorescence Detection of Ergotamine
por: Shakeel, Faiyaz, et al.
Publicado: (2023)

Experimental and Computational Approaches for Solubility Measurement of Pyridazinone Derivative in Binary (DMSO + Water) Systems
por: Shakeel, Faiyaz, et al.
Publicado: (2019)

Combination of Cellulose Derivatives and Chitosan-Based Polymers to Investigate the Effect of Permeation Enhancers Added to In Situ Nasal Gels for the Controlled Release of Loratadine and Chlorpheniramine
por: Viswanadhan Vasantha, Prasanth, et al.
Publicado: (2023)

Simultaneous Estimation of Cinnamaldehyde and Eugenol in Essential Oils and Traditional and Ultrasound-Assisted Extracts of Different Species of Cinnamon Using a Sustainable/Green HPTLC Technique
por: Foudah, Ahmed I., et al.
Publicado: (2021)

Simple and Accurate HPTLC-Densitometric Method for Quantification of Delafloxacin (A Novel Fluoroquinolone Antibiotic) in Plasma Samples: Application to Pharmacokinetic Study in Rats
por: Alam, Prawez, et al.
Publicado: (2020)

The Therapeutic and Prophylactic Potential of Quercetin against COVID-19: An Outlook on the Clinical Studies, Inventive Compositions, and Patent Literature
por: Imran, Mohd, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_s1hqvg1ea3nevv789i9ud8ifv5