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Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery

Background: procalcitonin is a valuable marker in the diagnosis of bacterial infections; however, the impairment of renal function can influence its diagnostic precision. The objective of this study is to evaluate the differential behaviour of procalcitonin, as well as its usefulness in the diagnosi...

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Autores principales: de la Varga-Martínez, Olga, Martín-Fernández, Marta, Heredia-Rodríguez, María, Ceballos, Francisco, Cubero-Gallego, Hector, Priede-Vimbela, Juan Manuel, Bardají-Carrillo, Miguel, Sánchez-de Prada, Laura, López-Herrero, Rocío, Jorge-Monjas, Pablo, Tamayo, Eduardo, Gómez-Sánchez, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781060/
https://www.ncbi.nlm.nih.gov/pubmed/36555891
http://dx.doi.org/10.3390/jcm11247274
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author de la Varga-Martínez, Olga
Martín-Fernández, Marta
Heredia-Rodríguez, María
Ceballos, Francisco
Cubero-Gallego, Hector
Priede-Vimbela, Juan Manuel
Bardají-Carrillo, Miguel
Sánchez-de Prada, Laura
López-Herrero, Rocío
Jorge-Monjas, Pablo
Tamayo, Eduardo
Gómez-Sánchez, Esther
author_facet de la Varga-Martínez, Olga
Martín-Fernández, Marta
Heredia-Rodríguez, María
Ceballos, Francisco
Cubero-Gallego, Hector
Priede-Vimbela, Juan Manuel
Bardají-Carrillo, Miguel
Sánchez-de Prada, Laura
López-Herrero, Rocío
Jorge-Monjas, Pablo
Tamayo, Eduardo
Gómez-Sánchez, Esther
author_sort de la Varga-Martínez, Olga
collection PubMed
description Background: procalcitonin is a valuable marker in the diagnosis of bacterial infections; however, the impairment of renal function can influence its diagnostic precision. The objective of this study is to evaluate the differential behaviour of procalcitonin, as well as its usefulness in the diagnosis of postoperative pulmonary infection after cardiac surgery, depending on the presence or absence of impaired renal function. Materials and methods: A total of 805 adult patients undergoing cardiac surgery with extracorporeal circulation (CBP) were prospectively recruited, comparing the behaviour of biomarkers between the groups with and without postoperative pneumonia and according to the presence or absence of renal dysfunction. Results: Pulmonary infection was diagnosed in 42 patients (5.21%). In total, 228 patients (28.32%) presented postoperative renal dysfunction. Procalcitonin was significantly higher in infected patients, even in the presence of renal dysfunction. The optimal procalcitonin threshold differed markedly in patients with renal dysfunction compared to patients without renal dysfunction (1 vs. 0.78 ng/mL p < 0.05). The diagnostic accuracy of procalcitonin increased significantly when the procalcitonin threshold was adapted to renal function. Conclusions: Procalcitonin is an accurate marker of postoperative infection in cardiac surgery, even in the presence of renal dysfunction. Renal function is an important determinant of procalcitonin levels and, therefore, its diagnostic thresholds must be adapted in the presence of renal dysfunction.
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spelling pubmed-97810602022-12-24 Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery de la Varga-Martínez, Olga Martín-Fernández, Marta Heredia-Rodríguez, María Ceballos, Francisco Cubero-Gallego, Hector Priede-Vimbela, Juan Manuel Bardají-Carrillo, Miguel Sánchez-de Prada, Laura López-Herrero, Rocío Jorge-Monjas, Pablo Tamayo, Eduardo Gómez-Sánchez, Esther J Clin Med Article Background: procalcitonin is a valuable marker in the diagnosis of bacterial infections; however, the impairment of renal function can influence its diagnostic precision. The objective of this study is to evaluate the differential behaviour of procalcitonin, as well as its usefulness in the diagnosis of postoperative pulmonary infection after cardiac surgery, depending on the presence or absence of impaired renal function. Materials and methods: A total of 805 adult patients undergoing cardiac surgery with extracorporeal circulation (CBP) were prospectively recruited, comparing the behaviour of biomarkers between the groups with and without postoperative pneumonia and according to the presence or absence of renal dysfunction. Results: Pulmonary infection was diagnosed in 42 patients (5.21%). In total, 228 patients (28.32%) presented postoperative renal dysfunction. Procalcitonin was significantly higher in infected patients, even in the presence of renal dysfunction. The optimal procalcitonin threshold differed markedly in patients with renal dysfunction compared to patients without renal dysfunction (1 vs. 0.78 ng/mL p < 0.05). The diagnostic accuracy of procalcitonin increased significantly when the procalcitonin threshold was adapted to renal function. Conclusions: Procalcitonin is an accurate marker of postoperative infection in cardiac surgery, even in the presence of renal dysfunction. Renal function is an important determinant of procalcitonin levels and, therefore, its diagnostic thresholds must be adapted in the presence of renal dysfunction. MDPI 2022-12-07 /pmc/articles/PMC9781060/ /pubmed/36555891 http://dx.doi.org/10.3390/jcm11247274 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de la Varga-Martínez, Olga
Martín-Fernández, Marta
Heredia-Rodríguez, María
Ceballos, Francisco
Cubero-Gallego, Hector
Priede-Vimbela, Juan Manuel
Bardají-Carrillo, Miguel
Sánchez-de Prada, Laura
López-Herrero, Rocío
Jorge-Monjas, Pablo
Tamayo, Eduardo
Gómez-Sánchez, Esther
Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery
title Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery
title_full Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery
title_fullStr Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery
title_full_unstemmed Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery
title_short Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery
title_sort influence of renal dysfunction on the differential behaviour of procalcitonin for the diagnosis of postoperative infection in cardiac surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781060/
https://www.ncbi.nlm.nih.gov/pubmed/36555891
http://dx.doi.org/10.3390/jcm11247274
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