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Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery
Background: procalcitonin is a valuable marker in the diagnosis of bacterial infections; however, the impairment of renal function can influence its diagnostic precision. The objective of this study is to evaluate the differential behaviour of procalcitonin, as well as its usefulness in the diagnosi...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781060/ https://www.ncbi.nlm.nih.gov/pubmed/36555891 http://dx.doi.org/10.3390/jcm11247274 |
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author | de la Varga-Martínez, Olga Martín-Fernández, Marta Heredia-Rodríguez, María Ceballos, Francisco Cubero-Gallego, Hector Priede-Vimbela, Juan Manuel Bardají-Carrillo, Miguel Sánchez-de Prada, Laura López-Herrero, Rocío Jorge-Monjas, Pablo Tamayo, Eduardo Gómez-Sánchez, Esther |
author_facet | de la Varga-Martínez, Olga Martín-Fernández, Marta Heredia-Rodríguez, María Ceballos, Francisco Cubero-Gallego, Hector Priede-Vimbela, Juan Manuel Bardají-Carrillo, Miguel Sánchez-de Prada, Laura López-Herrero, Rocío Jorge-Monjas, Pablo Tamayo, Eduardo Gómez-Sánchez, Esther |
author_sort | de la Varga-Martínez, Olga |
collection | PubMed |
description | Background: procalcitonin is a valuable marker in the diagnosis of bacterial infections; however, the impairment of renal function can influence its diagnostic precision. The objective of this study is to evaluate the differential behaviour of procalcitonin, as well as its usefulness in the diagnosis of postoperative pulmonary infection after cardiac surgery, depending on the presence or absence of impaired renal function. Materials and methods: A total of 805 adult patients undergoing cardiac surgery with extracorporeal circulation (CBP) were prospectively recruited, comparing the behaviour of biomarkers between the groups with and without postoperative pneumonia and according to the presence or absence of renal dysfunction. Results: Pulmonary infection was diagnosed in 42 patients (5.21%). In total, 228 patients (28.32%) presented postoperative renal dysfunction. Procalcitonin was significantly higher in infected patients, even in the presence of renal dysfunction. The optimal procalcitonin threshold differed markedly in patients with renal dysfunction compared to patients without renal dysfunction (1 vs. 0.78 ng/mL p < 0.05). The diagnostic accuracy of procalcitonin increased significantly when the procalcitonin threshold was adapted to renal function. Conclusions: Procalcitonin is an accurate marker of postoperative infection in cardiac surgery, even in the presence of renal dysfunction. Renal function is an important determinant of procalcitonin levels and, therefore, its diagnostic thresholds must be adapted in the presence of renal dysfunction. |
format | Online Article Text |
id | pubmed-9781060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-97810602022-12-24 Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery de la Varga-Martínez, Olga Martín-Fernández, Marta Heredia-Rodríguez, María Ceballos, Francisco Cubero-Gallego, Hector Priede-Vimbela, Juan Manuel Bardají-Carrillo, Miguel Sánchez-de Prada, Laura López-Herrero, Rocío Jorge-Monjas, Pablo Tamayo, Eduardo Gómez-Sánchez, Esther J Clin Med Article Background: procalcitonin is a valuable marker in the diagnosis of bacterial infections; however, the impairment of renal function can influence its diagnostic precision. The objective of this study is to evaluate the differential behaviour of procalcitonin, as well as its usefulness in the diagnosis of postoperative pulmonary infection after cardiac surgery, depending on the presence or absence of impaired renal function. Materials and methods: A total of 805 adult patients undergoing cardiac surgery with extracorporeal circulation (CBP) were prospectively recruited, comparing the behaviour of biomarkers between the groups with and without postoperative pneumonia and according to the presence or absence of renal dysfunction. Results: Pulmonary infection was diagnosed in 42 patients (5.21%). In total, 228 patients (28.32%) presented postoperative renal dysfunction. Procalcitonin was significantly higher in infected patients, even in the presence of renal dysfunction. The optimal procalcitonin threshold differed markedly in patients with renal dysfunction compared to patients without renal dysfunction (1 vs. 0.78 ng/mL p < 0.05). The diagnostic accuracy of procalcitonin increased significantly when the procalcitonin threshold was adapted to renal function. Conclusions: Procalcitonin is an accurate marker of postoperative infection in cardiac surgery, even in the presence of renal dysfunction. Renal function is an important determinant of procalcitonin levels and, therefore, its diagnostic thresholds must be adapted in the presence of renal dysfunction. MDPI 2022-12-07 /pmc/articles/PMC9781060/ /pubmed/36555891 http://dx.doi.org/10.3390/jcm11247274 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article de la Varga-Martínez, Olga Martín-Fernández, Marta Heredia-Rodríguez, María Ceballos, Francisco Cubero-Gallego, Hector Priede-Vimbela, Juan Manuel Bardají-Carrillo, Miguel Sánchez-de Prada, Laura López-Herrero, Rocío Jorge-Monjas, Pablo Tamayo, Eduardo Gómez-Sánchez, Esther Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery |
title | Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery |
title_full | Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery |
title_fullStr | Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery |
title_full_unstemmed | Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery |
title_short | Influence of Renal Dysfunction on the Differential Behaviour of Procalcitonin for the Diagnosis of Postoperative Infection in Cardiac Surgery |
title_sort | influence of renal dysfunction on the differential behaviour of procalcitonin for the diagnosis of postoperative infection in cardiac surgery |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781060/ https://www.ncbi.nlm.nih.gov/pubmed/36555891 http://dx.doi.org/10.3390/jcm11247274 |
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