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Prediction of Drug–Drug–Gene Interaction Scenarios of (E)-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling

Clomiphene, a selective estrogen receptor modulator (SERM), has been used for the treatment of anovulation for more than 50 years. However, since (E)-clomiphene ((E)-Clom) and its metabolites are eliminated primarily via Cytochrome P450 (CYP) 2D6 and CYP3A4, exposure can be affected by CYP2D6 polymo...

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Detalles Bibliográficos
Autores principales:	Kovar, Christina, Kovar, Lukas, Rüdesheim, Simeon, Selzer, Dominik, Ganchev, Boian, Kröner, Patrick, Igel, Svitlana, Kerb, Reinhold, Schaeffeler, Elke, Mürdter, Thomas E., Schwab, Matthias, Lehr, Thorsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781104/ https://www.ncbi.nlm.nih.gov/pubmed/36559098 http://dx.doi.org/10.3390/pharmaceutics14122604

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