Cargando…

Characterization of COVID-19-Related Lung Involvement in Patients Undergoing Magnetic Resonance T1 and T2 Mapping Imaging: A Pilot Study

Tissue characterization by mapping techniques is a recent magnetic resonance imaging (MRI) tool that could aid the tissue characterization of lung parenchyma in coronavirus disease-2019 (COVID-19). The aim of the present study was to compare lung MRI findings, including T1 and T2 mapping, in a group...

Descripción completa

Detalles Bibliográficos
Autores principales: Camastra, Giovanni, Arcari, Luca, Ciolina, Federica, Danti, Massimiliano, Ansalone, Gerardo, Cacciotti, Luca, Sbarbati, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781162/
https://www.ncbi.nlm.nih.gov/pubmed/36547479
http://dx.doi.org/10.3390/jimaging8120314
_version_ 1784857006304133120
author Camastra, Giovanni
Arcari, Luca
Ciolina, Federica
Danti, Massimiliano
Ansalone, Gerardo
Cacciotti, Luca
Sbarbati, Stefano
author_facet Camastra, Giovanni
Arcari, Luca
Ciolina, Federica
Danti, Massimiliano
Ansalone, Gerardo
Cacciotti, Luca
Sbarbati, Stefano
author_sort Camastra, Giovanni
collection PubMed
description Tissue characterization by mapping techniques is a recent magnetic resonance imaging (MRI) tool that could aid the tissue characterization of lung parenchyma in coronavirus disease-2019 (COVID-19). The aim of the present study was to compare lung MRI findings, including T1 and T2 mapping, in a group of n = 11 patients with COVID-19 pneumonia who underwent a scheduled cardiac MRI, and a cohort of healthy controls. MRI scout images were used to identify affected and remote lung regions within the patients’ cohort and appropriate regions of interest (ROIs) were drawn accordingly. Both lung native T1 and T2 values were significantly higher in the affected areas of patients with COVID-19 as compared to the controls (1375 ms vs. 1201 ms, p = 0.016 and 70 ms vs. 30 ms, p < 0.001, respectively), whereas no significant differences were detected between the remote lung parenchyma of the COVID-19 patients and the controls (both p > 0.05). When a larger ROI was identified, comprising the whole lung parenchyma within the image irrespective of the affected and remote areas, the COVID-19 patients still retained higher native T1 (1278 ms vs. 1149 ms, p = 0.003) and T2 values (38 ms vs. 34 ms, p = 0.04). According to the receiver operator characteristics curves, the T2 value of the affected region retained the higher accuracy for the differentiation of the COVID-19 patients against the controls (area under the curve 0.934, 95% confidence interval 0.826–0.999). These findings, possibly driven by the ability of MRI tissue mapping to detect ongoing inflammation in the lungs of patients with COVID-19, suggest that T1 and T2 mapping of the lung is a feasible approach in this clinical scenario.
format Online
Article
Text
id pubmed-9781162
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-97811622022-12-24 Characterization of COVID-19-Related Lung Involvement in Patients Undergoing Magnetic Resonance T1 and T2 Mapping Imaging: A Pilot Study Camastra, Giovanni Arcari, Luca Ciolina, Federica Danti, Massimiliano Ansalone, Gerardo Cacciotti, Luca Sbarbati, Stefano J Imaging Article Tissue characterization by mapping techniques is a recent magnetic resonance imaging (MRI) tool that could aid the tissue characterization of lung parenchyma in coronavirus disease-2019 (COVID-19). The aim of the present study was to compare lung MRI findings, including T1 and T2 mapping, in a group of n = 11 patients with COVID-19 pneumonia who underwent a scheduled cardiac MRI, and a cohort of healthy controls. MRI scout images were used to identify affected and remote lung regions within the patients’ cohort and appropriate regions of interest (ROIs) were drawn accordingly. Both lung native T1 and T2 values were significantly higher in the affected areas of patients with COVID-19 as compared to the controls (1375 ms vs. 1201 ms, p = 0.016 and 70 ms vs. 30 ms, p < 0.001, respectively), whereas no significant differences were detected between the remote lung parenchyma of the COVID-19 patients and the controls (both p > 0.05). When a larger ROI was identified, comprising the whole lung parenchyma within the image irrespective of the affected and remote areas, the COVID-19 patients still retained higher native T1 (1278 ms vs. 1149 ms, p = 0.003) and T2 values (38 ms vs. 34 ms, p = 0.04). According to the receiver operator characteristics curves, the T2 value of the affected region retained the higher accuracy for the differentiation of the COVID-19 patients against the controls (area under the curve 0.934, 95% confidence interval 0.826–0.999). These findings, possibly driven by the ability of MRI tissue mapping to detect ongoing inflammation in the lungs of patients with COVID-19, suggest that T1 and T2 mapping of the lung is a feasible approach in this clinical scenario. MDPI 2022-11-23 /pmc/articles/PMC9781162/ /pubmed/36547479 http://dx.doi.org/10.3390/jimaging8120314 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Camastra, Giovanni
Arcari, Luca
Ciolina, Federica
Danti, Massimiliano
Ansalone, Gerardo
Cacciotti, Luca
Sbarbati, Stefano
Characterization of COVID-19-Related Lung Involvement in Patients Undergoing Magnetic Resonance T1 and T2 Mapping Imaging: A Pilot Study
title Characterization of COVID-19-Related Lung Involvement in Patients Undergoing Magnetic Resonance T1 and T2 Mapping Imaging: A Pilot Study
title_full Characterization of COVID-19-Related Lung Involvement in Patients Undergoing Magnetic Resonance T1 and T2 Mapping Imaging: A Pilot Study
title_fullStr Characterization of COVID-19-Related Lung Involvement in Patients Undergoing Magnetic Resonance T1 and T2 Mapping Imaging: A Pilot Study
title_full_unstemmed Characterization of COVID-19-Related Lung Involvement in Patients Undergoing Magnetic Resonance T1 and T2 Mapping Imaging: A Pilot Study
title_short Characterization of COVID-19-Related Lung Involvement in Patients Undergoing Magnetic Resonance T1 and T2 Mapping Imaging: A Pilot Study
title_sort characterization of covid-19-related lung involvement in patients undergoing magnetic resonance t1 and t2 mapping imaging: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9781162/
https://www.ncbi.nlm.nih.gov/pubmed/36547479
http://dx.doi.org/10.3390/jimaging8120314
work_keys_str_mv AT camastragiovanni characterizationofcovid19relatedlunginvolvementinpatientsundergoingmagneticresonancet1andt2mappingimagingapilotstudy
AT arcariluca characterizationofcovid19relatedlunginvolvementinpatientsundergoingmagneticresonancet1andt2mappingimagingapilotstudy
AT ciolinafederica characterizationofcovid19relatedlunginvolvementinpatientsundergoingmagneticresonancet1andt2mappingimagingapilotstudy
AT dantimassimiliano characterizationofcovid19relatedlunginvolvementinpatientsundergoingmagneticresonancet1andt2mappingimagingapilotstudy
AT ansalonegerardo characterizationofcovid19relatedlunginvolvementinpatientsundergoingmagneticresonancet1andt2mappingimagingapilotstudy
AT cacciottiluca characterizationofcovid19relatedlunginvolvementinpatientsundergoingmagneticresonancet1andt2mappingimagingapilotstudy
AT sbarbatistefano characterizationofcovid19relatedlunginvolvementinpatientsundergoingmagneticresonancet1andt2mappingimagingapilotstudy